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Ghrelin exhibited antidepressant and anxiolytic effect via the p38-MAPK signaling pathway in hippocampus
Publication date: Available online 8 March 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Qiu-Qin Han, Hui-Jie Huang, Ya-Lin Wang, Liu Yang, Adam Pilot, Xiao-Cang Zhu, Rui Yu, Jing Wang, Xiao-Rong Chen, Qiong Liu, Bing Li, Gen-Cheng Wu, Jin YuAbstractGhrelin, a peptide derived from stomach, is an endogenous ligand for growth hormone secretagogue receptor (GHSR). So far, the exact role of ghrelin in depression and anxiety is still being debated. The p38 mitogen-activated protein kinase (p38-MAPK) is known to be activated in response to various stress stimuli. Thus, we hypothesize that g...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 8, 2019 Category: Psychiatry Source Type: research