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Source: Molecular Biology Reports
Condition: Age-Related Macular Degeneration (AMD)
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Total 1 results found since Jan 2013.
Osmotic induction of placental growth factor in retinal pigment epithelial cells in vitro: contribution of NFAT5 activity.
Abstract
One risk factor of neovascular age-related macular degeneration is systemic hypertension; hypertension is mainly caused by extracellular hyperosmolarity after consumption of dietary salt. In retinal pigment epithelial (RPE) cells, high extracellular osmolarity induces vascular endothelial growth factor (VEGF)-A (Hollborn et al. in Mol Vis 21:360-377, 2015). The aim of the present study was to determine whether extracellular hyperosmolarity and chemical hypoxia trigger the expression of further VEGF family members including placental growth factor (PlGF) in human RPE cells. Hyperosmotic media were made up ...
Source: Molecular Biology Reports - May 25, 2016 Category: Molecular Biology Authors: Hollborn M, Reichmuth K, Prager P, Wiedemann P, Bringmann A, Kohen L Tags: Mol Biol Rep Source Type: research
