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Source: Chemosphere
Condition: Chronic Obstructive Pulmonary
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Total 3 results found since Jan 2013.
Wood smoke particulate matter (WSPM2.5) induces pyroptosis through both caspase-1/IL-1 β/IL-18 and ATP/P2Y-dependent mechanisms in human bronchial epithelial cells
In this study, biofuel PM2.5 extracted from wood smoke (WSPM2.5) was used according to our previous publication. A 16-HBE cell line was used as the cell model. Results showed that: Firstly, WSPM2.5 induced significant pyroptosis in 16-HBE cells, reflected by the typical changes including elevated release of lactate dehydrogenase release (LDH) and activated activity and expression of Caspase-1/IL-1β/IL-18 signaling pathway. Then, specific inhibitors for both Caspases (Z-VAD-FMK) and Caspase-1 (VX-765), as well as specific siRNA knockdown of IL-1β all effectively attenuated the WSPM2.5-induced upregulation of downstream in...
Source: Chemosphere - July 19, 2022 Category: Chemistry Authors: Xin Fu Wei Hong Shuyi Li Zhi Chen Wenqu Zhou Jianwei Dai Xiaoliang Deng Hongbin Zhou Bing Li Pixin Ran Source Type: research
