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The role of retinoid-related orphan receptor- α in cigarette smoke-induced autophagic response
CONCLUSIONS: Our findings suggest that RORα promotes autophagy and contributes to COPD pathogenesis via regulation of the RORα-p53-DRAM pathway.PMID:35509068 | DOI:10.1186/s12931-022-02034-5
Source: Respiratory Care - May 5, 2022 Category: Respiratory Medicine Authors: Hak-Su Kim Chang Hyeok An Danielle Teller Su-Jin Moon Gi Won Hwang Jin Woo Song Source Type: research

Epithelium-derived IL17A Promotes Cigarette Smoke-induced Inflammation and Mucus Hyperproduction
In this study, we aim to determine whether epithelial-derived IL17A regulates inflammation and mucus hyperproduction in COPD using a cultured human bronchial epithelial (HBE) cell line in vitro and airway epithelium IL17A-specific knockout mouse in vivo. Increased IL17A expression was observed in mouse airway epithelium upon cigarette smoke (CS) exposure or in a COPD mouse model that was induced by CS and elastin. CS extract (CSE) also triggered IL17A expression in HBE cells. Blocking IL17A or IL17RA effectively attenuated CSE-induced MUC5AC and the inflammatory cytokines IL6, tumor necrosis factor (TNF)-α, and IL1β in H...
Source: Respiratory Care - June 29, 2021 Category: Respiratory Medicine Authors: Mindan Wu Tianwen Lai Du Jing Shiyi Yang Yanping Wu Zhouyang Li Yinfang Wu Yun Zhao Lingren Zhou Haipin Chen Jiaxin Shen Wen Li Songmin Ying Zhihua Chen Xiaohong Wu Huahao Shen Source Type: research