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Abstract 4427: Apoptosis, autophagy and ATP: The dynamic interaction of cellular ATP and drug resistance in MET amplified gastric cancer
Conclusions: Overall, our data reveal a novel relationship between low ATP levels and resistance to MET inhibitor-induced cell death. Clinically this is significant because it may discourage the use of combination therapies with autophagy inhibitors in gastric cancer patients whose tumors contain MET amplification.Citation Format: Rebecca Dunbar Schroeder, David Hong, David J. McConkey. Apoptosis, autophagy and ATP: The dynamic interaction of cellular ATP and drug resistance in MET amplified gastric cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Dunbar Schroeder, R., Hong, D., McConkey, D. J. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 4440: The functional role of insulin-like growth factor binding protein-2 in esophageal adenocarcinoma chemoresistance
Despite improved understanding of esophageal adenocarcinoma (EAC) progression and advances in endoscopic surveillance and multimodality treatment, patients commonly present with advanced stage disease and demonstrate resistance to therapy, with complete response rates below 40%. Understanding the molecular mechanisms of resistance is crucial for predicting and overcoming this resistance.IGFBP2 is a member of the IGFBP family of proteins that has been shown to modulate both insulin growth factor (IGF) and integrin signaling and is a mediator of cell growth, invasion and resistance in other tumor types. Because these pathway...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Myers, A. L., Lin, L., Nancarrow, D. J., Wang, Z., Ferrer-Torres, D., Beer, D. G., Chang, A. C. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 1429: Contribution of membrane-bound carboxypeptidase M to tumor growth and metastasis by regulating epithelial mesenchymal transition in esophageal squamous carcinoma
In this study, we examined the properties of CPM for tumor growth and metastasis in human esophageal carcinoma cells. In order to investigate the expression of CPM on human tumor cells, we established the monoclonal antibody specific for human CPM and found the constitutive expression of CPM on various human carcinomas by flow cytometry and confocal laser microscopy. Treatment of cancer cells with EMT-mediated cytokines, including TGF-beta, IL-6 and OSM, increased CPM expression on their cell surface followed by enhancement of cell migration and change of cell shapes from epithelial to mesenchymal type. Silencing CPM expre...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Kudo, Y., Fukuda, J., Harigai, R., Kato, K. Tags: Tumor Biology Source Type: research

Abstract 519: V-set and immunoglobulin domain containing 1 (VSIG1) demonstrates a tumor suppressive function in gastric cancer and non-small cell lung cancer
V-set and immunoglobulin domain containing 1 (VSIG1) was recently identified as a novel member of immunoglobulin-like cell-adhesion molecules. In human, VSIG1 has 2 transcript variant forms (variant 1 and variant 2). In normal tissues, VSIG1 was reported to be expressed predominantly in stomach and testis. In cancerous tissues, the expression of VSIG1 was shown to be restricted in a part of gastric, esophageal, and ovarian cancers. However, the role of VSIG1 in cancer progression has not been elucidated.VSIG1 protein expression in human normal tissues obtained at autopsy was detected by western blot analysis. We also analy...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Inoue, Y., Kurabe, N., Matsuura, S., Maeda, M., Kahyo, T., Igarashi, H., Funai, K., Niwa, H., Ogawa, H., Shinmura, K., Konno, H., Suda, T., Sugimura, H. Tags: Tumor Biology Source Type: research

Abstract 2389: Eps8: a negative regulator of myofibroblast differentiation and function
In this study we investigate the mechanisms regulating myofibroblast differentiation and function, and identify the adapter protein Epidermal growth factor receptor kinase substrate 8 (Eps8) as a negative regulator of the cancer-associated myofibroblast phenotype.Cancer-associated fibroblasts (CAFs) are a heterogenous, poorly defined cell population. Most commonly CAFs are identified by de novo expression of α-smooth muscle actin (αSMA) incorporated into stress fibres generating enhanced contractility, which is associated with an enhanced secretory profile. Myofibroblasts promote a number of the hallmarks of malignancy, ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Frampton, S. J., Jenei, V., Mellone, M., Hanley, C. J., Rucka, M. M., Tod, J., Moutasim, K. A., King, E. V., Thomas, G. Tags: Tumor Biology Source Type: research

Abstract 2923: Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
MAPK7/ERK5 (extracellular-signal-regulated kinase 5) is the effector kinase of a canonical three-tiered MAPK (mitogen activated protein kinase) signalling cascade comprising MEK (MAPK/ERK kinase) 5, MEKK(MEK kinase) 2/3 and ERK5 itself(1). Under normal physiological conditions, MEK5 and ERK5 are ubiquitously expressed and are activated by growth factors and cellular stresses to perform roles in blood vessel, cardiac and muscle development(2). Although the MAPK7-axis is the least well studied of the MAPK-signaling pathways, evidence suggests that it plays a role in the pathology of cancer, in particular; breast cancer progr...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Gavine, P. R., Wang, M., Yu, D., Hu, E., Huang, C., Xia, J., Su, X., Fan, J., Zhang, T., Ye, Q., Zheng, L., Xie, L., Han, L., Zhu, G., Qian, Z., Luo, Q., Hou, Y., Ji, Q. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 5312: Quantitative proteomic analysis of cell-surface membrane proteins: Biomarker discovery in esophageal squamous cancer
Conclusions. By using a high throughput cell-surface membrane proteomic analysis combining biotinylation of cell-surface membrane protein and iTRAQ technology, several ESCC candidate antigens were identified. Further studies on the physiological role of novel tumor antigens overexpressed in ESCC and their application as biomarkers/therapeutic targets are underway. . Note: This abstract was not presented at the meeting. Citation Format: Emi Harada, Satoshi Serada, Tsuyoshi Takahashi, Minoru Fujimoto, Tetsuji Naka. Quantitative proteomic analysis of cell-surface membrane proteins: Biomarker discovery in esophageal squamous c...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Harada, E., Serada, S., Takahashi, T., Fujimoto, M., Naka, T. Tags: Molecular and Cellular Biology Source Type: research

Abstract 2225: Comprehensive molecular characterization of esophageal squamous cell carcinoma
Conclusions By demonstrating the genomic landscape of over 180 ESCC cases, our integrated study unmasks a number of novel genetic lesions in ESCC and provides an important molecular foundation for understanding esophageal tumors and developing therapeutic targets. Citation Format: Dechen Lin, Xuan Meng, Liang Xu, Lingwen Ding, Manoj Garg, Henry Yang, Lizhen Liu, Jiajie Hao, Mingrong Wang, Yasunobu Nagata, Yusuke Sato, Yusuke Okuno, Seishi Ogawa, Phillip Koeffler. Comprehensive molecular characterization of esophageal squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Associatio...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Lin, D., Meng, X., Xu, L., Ding, L., Garg, M., Yang, H., Liu, L., Hao, J., Wang, M., Nagata, Y., Sato, Y., Okuno, Y., Ogawa, S., Koeffler, P. Tags: Molecular and Cellular Biology Source Type: research

Abstract 764: A role for GLI1 in the development of multidrug resistance in rhabdomyosarcoma (RMS) cells
RMS is the most common sarcoma of childhood. About 30% of patients with localized tumors will recur following treatment. The outcome for patients with recurrent RMS remains poor. Therefore, development of chemotherapy resistance during RMS therapy represents an important problem and novel approaches to prevent or reverse drug resistance are essential. Activation of multidrug transporter genes, including MDR1, MRP1, LRP and TAP1 represents an important mechanism for drug resistance in RMS. However, the mechanism of expression of multidrug resistance genes in RMS is incompletely understood. Recent reports have suggested a ro...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Yoon, J. W., Lamm, M., Leong, K.-F., Iannaccone, S., Iannaccone, P., Walterhouse, D. Tags: Experimental and Molecular Therapeutics Source Type: research

EPHB4 Biomarker in Esophageal Cancers
Esophageal cancer incidence is increasing and has few treatment options. In studying receptor tyrosine kinases associated with esophageal cancers, we have identified EPHB4 to be robustly overexpressed in cell lines and primary tumor tissues. In total, 94 squamous cell carcinoma, 82 adenocarcinoma, 25 dysplasia, 13 Barrett esophagus, and 25 adjacent or unrelated normal esophageal tissues were evaluated by immunohistochemistry. EPHB4 expression was significantly higher in all the different histologic categories than in adjacent normal tissues. In 13 esophageal cancer cell lines, 3 of the 9 SCC cell lines and 2 of the 4 adeno...
Source: Cancer Research - January 2, 2013 Category: Cancer & Oncology Authors: Hasina, R., Mollberg, N., Kawada, I., Mutreja, K., Kanade, G., Yala, S., Surati, M., Liu, R., Li, X., Zhou, Y., Ferguson, B. D., Nallasura, V., Cohen, K. S., Hyjek, E., Mueller, J., Kanteti, R., El Hashani, E., Kane, D., Shimada, Y., Lingen, M. W., Husain Tags: Molecular and Cellular Pathobiology Source Type: research