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Condition: Myeloproliferative Disorders
Cancer: Medulloblastoma
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Abstract 2090: GLI3 repressor levels determine Hedgehog pathway activity and predict response to Smoothened antagonist in acute myeloid leukemia
The Hedgehog (Hh) signaling pathway is activated in most hematological and solid cancers and is a promising target for therapeutic development. Deletions in the receptor Patched (PTCH) or activating mutations in the upstream positive regulator Smoothened (SMO) have been reported in a few cancers such as basal cell carcinoma and medulloblastoma, but are largely absent in most tumor types; therefore, the mechanism of pathway activation in most cancers remains unknown. In normal tissues, Hh pathway activation via PTCH/SMO causes an increase in the downstream activating transcription factor GLI1 and a decrease in the transcr...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Chaudhry, P., Singh, M., Triche, T., Jorapur, A., Gill, P. S., Merchant, A. Tags: Molecular and Cellular Biology Source Type: research
