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Knockdown of NF- κB activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway
CONCLUSIONS: NKAP as an oncogene regulates the development of PAAD cells. The research found that the mTOR signaling pathway is engaged in the oncogenic role of NKAP in PAAD for the first time.PMID:37486443 | DOI:10.1007/s11033-023-08665-1
Source: Cancer Control - July 24, 2023 Category: Cancer & Oncology Authors: Xiangrong Xu Danyang Hou Yujie Wang Jing Zhang Yu Hei Bobo Wang Shuyue Tian Yunqing Zhang Fenghui Wang Source Type: research

Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stromal Cells as an Efficient Nanocarrier to Deliver siRNA or Drug to Pancreatic Cancer Cells
In conclusion, the use of UC-MSC-derived EVs as a drug delivery system for siRNAs or drugs could be a promising approach for the targeted treatment of PDAC.PMID:37296864 | DOI:10.3390/cancers15112901
Source: Cancer Control - June 10, 2023 Category: Cancer & Oncology Authors: Florian Draguet Nathan Dubois Cyril Bouland Karlien Pieters Dominique Bron Nathalie Meuleman Basile Stamatopoulos Laurence Lagneaux Source Type: research

SPOCK2 gene expression is downregulated in pancreatic ductal adenocarcinoma cells and correlates with prognosis of patients with pancreatic cancer
CONCLUSION: The expression of SPOCK2 is downregulated in PDAC as a result of hypermethylation of its corresponding gene. SPOCK2 expression as well as the demethylation of its gene could be a potential marker for PDAC.PMID:37188984 | DOI:10.1007/s00432-023-04845-5
Source: Cancer Control - May 15, 2023 Category: Cancer & Oncology Authors: Ughur Aghamaliyev Kaifeng Su Maximilian Weniger Dominik Koch Jan G D'Haese Jens Werner Alexandr V Bazhin Source Type: research

Nanoparticles of VAV1 siRNA combined with LL37 peptide for the treatment of pancreatic cancer
J Control Release. 2023 Feb 1:S0168-3659(23)00093-7. doi: 10.1016/j.jconrel.2023.01.084. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is among the leading causes of cancer-related death, and it is highly resistant to therapy owing to its unique extracellular matrix. VAV1 protein, overexpressed in several cancer diseases including pancreatic cancer (PC), increases tumor proliferation and enhances metastases formation, which are associated with decreased survival. We hypothesized that an additive anti-tumor effect could be obtained by co-encapsulating in PLGA nanoparticles (NPs), the negatively charg...
Source: Cancer Control - February 3, 2023 Category: Cancer & Oncology Authors: Majd Agbaria Doaa Jbara-Agbaria Etty Grad Meital Ben David-Naim Gil Aizik Gershon Golomb Source Type: research

Expression of kinesin family member C1 in pancreatic ductal adenocarcinoma affects tumor progression and stemness
This study aimed to analyze the expression and biological function of KIFC1 in PDAC. Immunohistochemically, KIFC1 was found in 37 of 81 PDAC cases (46%). A high expression of KIFC1 was significantly related to tumor size (p = 0.023) and poor overall survival (p = 0.011). Univariate and multivariate analysis indicated that KIFC1 expression was a prognostic factor in PDAC cases. As for cancer stem cell markers, KIFC1 expression tended to co-express significantly with CD44 (p < 0.01). The growth and spheroid colony formation of KIFC1 small interfering RNA (siRNA)-transfected PDAC cells were significantly lower than those o...
Source: Cancer Control - December 24, 2022 Category: Cancer & Oncology Authors: Akira Ishikawa Hiroki Fujii Takafumi Fukui Aya Kido Narutaka Katsuya Kazuhiro Sentani Kazuya Kuraoka Sho Tazuma Takeshi Sudo Masahiro Serikawa Shiro Oka Naohide Oue Source Type: research

Involvement of a AS3MT/c-Fos/p53 signaling axis in arsenic-induced tumor in human lung cells
In this study, we showed that AS3MT protein expression was higher in the arsenic-exposed population compared to the unexposed population. AS3MT was also overexpressed in human lung adenocarcinoma (A549) and human bronchial epithelial (16HBE) cells exposed to arsenic (A549: 20-60 μmol/L; 16HBE: 2-6 μmol/L) for 48 h. Furthermore, we investigated the effects of AS3MT on cell proliferation and apoptosis using siRNA. The downregulation of AS3MT inhibited the proliferation and promoted the apoptosis of cells. Mechanistically, AS3MT was found to specifically bind to c-Fos, thereby inhibiting the binding of c-Fos to c-Jun. Addit...
Source: Cancer Control - November 18, 2022 Category: Cancer & Oncology Authors: Mingjun Sun Huirong Cheng Tianle Yu Jingwen Tan Ming Li Qian Chen Yun Gu Chenglan Jiang Shuting Li Yuefeng He Weihua Wen Source Type: research

Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery
This study verifies the successful spray drying procedure of LNP-siRNA systems maintaining their integrity and mediating strong gene silencing efficiency on mRNA and protein levels both in vitro and ex vivo. The successful spray drying procedure of LNP-siRNA formulations in 5% lactose solution creates a novel siRNA-based therapy option to target respiratory diseases such as lung cancer, asthma, COPD, cystic fibrosis and viral infections.PMID:36126785 | DOI:10.1016/j.jconrel.2022.09.021
Source: Cancer Control - September 20, 2022 Category: Cancer & Oncology Authors: Christoph M Zimmermann Domizia Baldassi Karen Chan Nathan B P Adams Alina Neumann Diana Leidy Porras-Gonzalez Xin Wei Nikolaus Kneidinger Mircea Gabriel Stoleriu Gerald Burgstaller Dominik Witzigmann Paola Luciani Olivia M Merkel Source Type: research

Upregulation of dual-specificity phosphatase-26 is required for transforming growth factor β1(TGFβ1)-induced Epithelial-mesenchymal transition in A549 and PANC1 cells
CONCLUSIONS: Data provided suggest that TGFβ1 modulates the expression of DUSP genes and that upregulation of DUSP26 may be required for TGFβ1-promoted EMT in A549 and PANC1 cells. Further studies should be carried out to elucidate the requirement of individual DUSPs in TGFβ1-associated EMT in tumor cells.PMID:36053282 | DOI:10.1007/s11033-022-07893-1
Source: Cancer Control - September 2, 2022 Category: Cancer & Oncology Authors: Sabire Guler Berrin Zik Abdullah Yalcin Source Type: research

Junctional adhesion molecule-like protein promotes tumor progression via the Wnt/ β-catenin signaling pathway in lung adenocarcinoma
CONCLUSIONS: Our data reveal the oncogenic role of JAML in LUAD, indicating that JAML may be a predictive biomarker and novel therapeutic target for LUAD.PMID:35672776 | DOI:10.1186/s12967-022-03457-w
Source: Cancer Control - June 7, 2022 Category: Cancer & Oncology Authors: Qian Wu Rui Li Qing-Xiang Wang Meng-Yu Zhang Ting-Ting Liu Yi-Qing Qu Source Type: research

LncRNA RP3-326I13.1 promotes cisplatin resistance in lung adenocarcinoma by binding to HSP90B and upregulating MMP13
In conclusion, RP3-326I13.1 could promote DDP-resistance of LAD by binding to HSP90B and upregulating human matrix metalloproteinase-13 (MMP-13) and may serve as a therapeutic target, as well as a biomarker for predicting DDP-resistance in LAD.Abbreviations:DDP: Cisplatin; LAD: Lung adenocarcinoma; LncRNAs: Long non-coding RNAs; qPCR: real-time fluorescent quantitative PCR; HSP90B: Heat shock protein HSP 90-beta; RPMI: Roswell Park Memorial Institute; FBS: Fetal bovine serum; CT: computed tomography; MRI: magnetic resonance imaging; RECIST: Response evaluation criteria in solid tumors; NC: Negative control; OE: overexpress...
Source: Cancer Control - March 17, 2022 Category: Cancer & Oncology Authors: Huixin Zhou Xiaolu Huang Wenjing Shi Shihao Xu Jie Chen Kate Huang Yumin Wang Source Type: research

Dexmedetomidine inhibits the growth and metastasis of esophageal cancer cells by down-regulation of lncRNA MALAT1
This study aims to evaluate the effect of dexmedetomidine (DEX)-on esophageal cancer (EC) via regulating long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). The effect of DEX on MALAT1 expression and EC cell viability was detected. EC cells were divided into Blank, DEX, scrambled/MALAT1 siRNA, and DEX + control/MALAT1 groups, followed by a series of experiments including quantitative reverse-transcription polymerase chain reaction (qRT-PCR), western blotting, 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT), Annexin V-FITC/PI staining, wound healing, and Transwell...
Source: Cancer Control - February 24, 2022 Category: Cancer & Oncology Authors: Wei Zhang Li Zhang Xiao-Jun Cai Dong Li Feng-Jun Cao Zhi-Gang Zuo Ying Song Xiong-Jie Yu Shan Liu Source Type: research

LncRNA NFYC-AS1 promotes the development of lung adenocarcinomas through autophagy, apoptosis, and MET/c-Myc oncogenic proteins
CONCLUSIONS: In summary, the above results suggest that NFYC-AS1 may promote the proliferation of LAUD through autophagy and apoptosis.PMID:34926665 | PMC:PMC8640918 | DOI:10.21037/atm-21-4995
Source: Cancer Control - December 20, 2021 Category: Cancer & Oncology Authors: Ye Song Jike Du Pinglan Lu Qingfeng Zou Shaoting Zeng Meiyuan Liu Xiaoye Hu Wen Ma Hanhong Lin Xiaoyan Liu Feiyu Niu Source Type: research

Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells.
Abstract Ammonium is a metabolic waste product mainly detoxified by the liver. Hepatic dysfunction can lead to cytotoxic accumulation of circulating ammonium and to subsequent encephalopathy. Transmembrane ammonium transport is a widely spread process ensured by the highly conserved proteins of the Mep-Amt-Rh superfamily, including the mammalian Rhesus (Rh) factors. The regulatory mechanisms involved in the control of RH genes expression remain poorly studied. Here we addressed the expression regulation of one of these factors, RHBG. We identify HepG2 hepatocellular carcinoma cells and SW480 colon adenocarcinoma c...
Source: Cancer Control - June 2, 2015 Category: Cancer & Oncology Authors: Merhi A, De Mees C, Abdo R, Victoria Alberola J, Marini AM Tags: PLoS One Source Type: research