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EPHB4 tyrosine‐kinase receptor expression and biological significance in soft tissue sarcoma
Abstract Soft tissue sarcomas (STS) are heterogeneous malignant tumors of mesenchymal origin. Due to low incidence and high number of different histological subtypes, their pathogenesis and thus potential targets for their therapy remain barely investigated. Several studies revealed significant higher EPHB4 expression in malignancies such as prostate and colorectal cancer showing survival advantages for these tumor cells. Therefore we studied the expression of EPHB4 in a total of 46 clinical human specimens of different STS and human fibroblasts. EPHB4 mRNA and protein expression were significantly increased in synovial sa...
Source: International Journal of Cancer - October 1, 2014 Category: Cancer & Oncology Authors: M Becerikli, B Merwart, MC Lam, P Suppelna, A Rittig, A Mirmohammedsadegh, I Stricker, C Theiss, B.B. Singer, F Jacobsen, L Steinstraesser Tags: Carcinogenesis Source Type: research

A mechanistic study on the metastasis inducing function of FUS‐CHOP fusion protein in liposarcoma
Abstract The FUS‐CHOP fusion protein has been found to be instrumental for specific oncogenic processes in liposarcoma, but its ability to induce metastasis and the underlying mechanisms by which this can be achieved remain unknown. In order to dissect its functional role in this context, we stably overexpressed this protein in SW872 liposarcoma and HT1080 fibrosarcoma cell lines, and were able to demonstrate that forced expression of FUS‐CHOP significantly increases migration and invasion, as well as enhances lung and liver metastasis in the in vivo chicken chorioallantoic membrane (CAM) model, that is proliferation i...
Source: International Journal of Cancer - November 28, 2013 Category: Cancer & Oncology Authors: Nitin Patil, Suhail Ahmed Kabeer Rasheed, Mohammed Abba, Jörg Hendrik Leupold, Matthias Schwarzbach, Heike Allgayer Tags: Cancer Cell Biology Source Type: research