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Source: Biochimica et Biophysica Acta (BBA) General Subjects
Cancer: Fibrosarcoma
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Receptor for hyaluronic acid- mediated motility (RHAMM) regulates HT1080 fibrosarcoma cell proliferation via a β-catenin/c-myc signaling axis
Conclusions LMWHA/RHAMM downstream signaling regulates fibrosarcoma cell growth in a β-catenin/c-myc dependent manner. General Significance. The present study suggests that RHAMM is a novel β-catenin intracellular binding partner, protecting β-catenin from degradation and supporting the nuclear translocation of this key cellular mediator, which results in c-myc activation and enhanced fibrosarcoma cell growth.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - January 27, 2016 Category: Biochemistry Source Type: research
