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Source: Radiation Oncology
Cancer: Fibrosarcoma
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Total 1 results found since Jan 2013.
The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion
Conclusions:
These results indicate that patupilone counteracts an IR-induced MMP activation process by the reduction of secreted TIMP-1 and TIMP-2 proteins, which are required for activation of MMPs. Since IR-induced MMP activity could contribute to tumor progression, treatment combination of IR with patupilone might be of great clinical benefit for tumor therapy.
Source: Radiation Oncology - April 30, 2013 Category: Cancer & Oncology Authors: Polina Furmanova-HollensteinAngela Broggini-TenzerMatthias EggelAnne-Laure MillardMartin Pruschy Source Type: research
