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Characterization of GRK5 as a novel regulator of rhabdomyosarcoma tumor cell growth and self-renewal.
Authors: Pham T, Robinson K, Vleeshouwer-Neumann T, Annis JE, Chen EY Abstract Rhabdomyosarcoma (RMS) is the most common soft-tissue pediatric sarcoma. Clinical outcomes for RMS patients with relapsed or metastatic disease remain poor. Treatment options remain limited, presenting an urgent need for novel therapeutic targets. Using a high-throughput siRNA screen against the human kinome, we identified GRK5, a G-protein receptor kinase, as a novel regulator of RMS tumor cell growth and self-renewal. Through functional assays in vitro and in vivo, we show that GRK5 regulates cell cycle in a kinase-independent manner t...
Source: Oncotarget - May 5, 2020 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Chorein addiction in VPS13A overexpressing rhabdomyosarcoma cells.
In conclusion, chorein is expressed in various cancer cells. In cells with high chorein expression levels chorein silencing promotes apoptotic cell death, an effect paralleled by down-regulation of PI-3K activity and BCL-2/Bax expression ratio. PMID: 25871399 [PubMed - as supplied by publisher]
Source: Oncotarget - April 17, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research