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Source: PLoS Genetics
Cancer: Rhabdomyosarcoma
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DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy
by Sean C. Shadle, Jun Wen Zhong, Amy E. Campbell, Melissa L. Conerly, Sujatha Jagannathan, Chao-Jen Wong, Timothy D. Morello, Silv ère M. van der Maarel, Stephen J. Tapscott
Facioscapulohumeral dystrophy (FSHD) is caused by the mis-expression of DUX4 in skeletal muscle cells. DUX4 is a transcription factor that activates genes normally associated with stem cell biology and its mis-expression in FSHD cells results in apoptosis. To identify genes and pathways necessary for DUX4-mediated apoptosis, we performed an siRNA screen in an RD rhabdomyosarcoma cell line with an inducibleDUX4 transgene. Our screen identified compon...
Source: PLoS Genetics - March 7, 2017 Category: Genetics & Stem Cells Authors: Sean C. Shadle Source Type: research
