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Chorein addiction in VPS13A overexpressing rhabdomyosarcoma cells.
In conclusion, chorein is expressed in various cancer cells. In cells with high chorein expression levels chorein silencing promotes apoptotic cell death, an effect paralleled by down-regulation of PI-3K activity and BCL-2/Bax expression ratio. PMID: 25871399 [PubMed - as supplied by publisher]
Source: Oncotarget - April 17, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Abstract 3966: PLK1 regulates PAX3-FOXO1 stability and its inhibition mediates regression of alveolar rhabdomyosarcoma xenograft tumors
Oncogenic addiction provides an opportunity to develop new treatment options, especially for childhood cancers. Pediatric tumors contain a lower number of oncogenic mutations compared to most adult cancers, suggesting stronger dependency on individual oncogenes, such as chimeric transcription factors that have the ability to control multiple oncogenic pathways. Taking advantage of this addiction, targeting of oncogenic transcription factors becomes a new powerful strategy for therapy of translocation positive pediatric tumors like alveolar rhabdomyosarcoma (aRMS), which is characterized by a very dismal prognosis. As trans...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Thalhammer, V., Herrero–Martin, D., Hecker, R., Laubscher, D., Lopez–Garcia, L., Wachtel, M., Bode, P., Schafer, B. Tags: Tumor Biology Source Type: research