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Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis.
Abstract Naringin, a citrus bioflavonoid, has anti-inflammatory actions and cardio- and neuroprotective effects. In addition, naringin exhibits multiple antitumor actions in several cancer types, including osteosarcoma, the most common type of bone cancer. Here, we show that naringin inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1), a transcriptional repressor of epithelial differentiation involved in tumor metastasis. Our expression analyses confirm that Zeb1 is highly expressed in osteosarcoma specimens and cell lines....
Source: Aging - December 22, 2018 Category: Biomedical Science Authors: Ming H, Chuang Q, Jiashi W, Bin L, Guangbin W, Xianglu J Tags: Aging (Albany NY) Source Type: research