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SENP1/HIF ‐1α feedback loop modulates hypoxia‐induced cell proliferation, invasion, and EMT in human osteosarcoma cells
Hypoxia is an element intrinsic to most solid‐tumor microenvironments, including that of osteosarcoma (OS), and is associated with resistance to therapy, poor survival, and a malignant phenotype. The purpose of the present study was to investigate the role and underlying mechanism of SUMO‐specific protease 1 (SENP1)/hypoxia‐inducible factor‐1α (HIF‐1α) feedback loop in hypoxic microenvironment of OS. We observed that the expression of SENP1 was remarkably upregulated in OS cells. Additionally, there was a concomitant high expression of HIF‐1α and SENP1 in MG‐63 cells under a hypoxic microenvironment. Inter...
Source: Journal of Cellular Biochemistry - September 27, 2017 Category: Biochemistry Authors: Xiaowei Wang, Xiaoju Liang, Huan Liang, Bing Wang Tags: RESEARCH ARTICLE Source Type: research

SENP1/HIF ‐1α feedback loop modulates hypoxia‐induced cell proliferation, invasion and EMT in human osteosarcoma cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - August 10, 2017 Category: Biochemistry Authors: Xiaowei Wang, Xiaoju Liang, Huan Liang, Bing Wang Tags: Article Source Type: research

Long Noncoding RNA GAS5 Suppresses Cell Growth and Epithelial –Mesenchymal Transition in Osteosarcoma by Regulating the miR‐221/ARHI Pathway
This study explored the potential functions and mechanisms of GAS5 in the tumorigenesis of osteosarcoma. Here, the expression of GAS5, miR‐221 and aplasia Ras homologue member I (ARHI) was determined in osteosarcoma tissues and cells by Real‐time PCR (RT‐qPCR). The underlying mechanism of GAS5 in osteosarcoma growth was analyzed via MTT, Transwell, RT‐qPCR, Western blot, dual‐luciferase reporter assay, RNA immunoprecipitation, and xenograft models after GAS5 overexpression. GAS5 and ARHI levels were significantly reduced, while miR‐221 increased, both in osteosarcoma tissues and cells. Overexpression of GAS5 su...
Source: Journal of Cellular Biochemistry - June 13, 2017 Category: Biochemistry Authors: Kaishan Ye, Shuanke Wang, Haihong Zhang, Hua Han, Bing Ma, Wei Nan Tags: Article Source Type: research

Long noncoding RNA GAS5 suppresses cell growth and epithelial ‐mesenchymal transition in osteosarcoma by regulating the miR‐221/ARHI pathway
This study explored the potential functions and mechanisms of GAS5 in the tumorigenesis of osteosarcoma. Here, the expression of GAS5, miR‐221 and aplasia Ras homologue member I (ARHI) was determined in osteosarcoma tissues and cells by Real‐time PCR (RT‐qPCR). The underlying mechanism of GAS5 in osteosarcoma growth was analyzed via MTT, Transwell, RT‐qPCR, Western blot, dual‐luciferase reporter assay, RNA immunoprecipitation, and xenograft models after GAS5 overexpression. GAS5 and ARHI levels were significantly reduced, while miR‐221 increased, both in osteosarcoma tissues and cells. Overexpression of GAS5 su...
Source: Journal of Cellular Biochemistry - May 18, 2017 Category: Biochemistry Authors: Kaishan Ye, Shuanke Wang, Haihong Zhang, Hua Han, Bing Ma, Wei Nan Tags: Article Source Type: research

Wnt/ β‐catenin Signaling Activates Expression of the Bone‐related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - March 28, 2017 Category: Biochemistry Authors: Oscar A. Vega, Claudia M.J. Lucero, Hector F. Araya, Sofia Jerez, Julio C. Tapia, Marcelo Antonelli, Flavio Salazar ‐Onfray, Facundo Las Heras, Roman Thaler, Scott M. Riester, Gary S. Stein, Andre J. van Wijnen, Mario A. Galindo Tags: Article Source Type: research