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Contribution of endoplasmic reticulum stress, MAPK and PI3K/Akt pathways to the apoptotic death induced by a penicillin derivative in melanoma cells
AbstractWe have previously examined the in vitro and in vivo antitumor action of TAP7f, a synthetic triazolylpeptidyl penicillin, on murine melanoma cells. In this work, we explored the signal transduction pathways modulated by TAP7f in murine B16-F0 and human A375 melanoma cells, and the contribution of some intracellular signals to the apoptotic cell death. TAP7f decreased ERK1/2 phosphorylation and increased phospho-p38, phospho-JNK and phospho-Akt levels. ERK1/2 blockage suppressed cell growth, while inhibition of p38, JNK and PI3K-I pathways reduced the antitumor effect of TAP7f. Pharmacological inhibition of p38 and ...
Source: Apoptosis - November 12, 2021 Category: Molecular Biology Source Type: research

& lt;i & lt;FOXC1-Mediated Effects of miR-204-5p on Melanoma Cell Proliferation
Mol Biol (Mosk). 2021 Jul-Aug;55(4):667-675. doi: 10.31857/S0026898421030058.ABSTRACTMicroRNAs epigenetically regulate physiological and pathological processes. Previously, we found that miR-204-5p is expressed at low levels in melanoma cells, and an increase in its level leads to a change in proliferation, migration, and invasion of these cancer cells. Now, using bioinformatics analysis, it has been shown that the target of miR-204-5p is FOXC1 transcription factor, which is implicated in carcinogenesis. Using the luciferase reporter assay, it was found that miR-204-5p suppresses expression of the FOXC1 gene by binding to ...
Source: Molekuliarnaia Biologiia - August 25, 2021 Category: Molecular Biology Authors: I Yu Dubovtseva M B Aksenenko E D Nikolaeva A S Averchuk A V Moshev A A Savchenko S V Markova T G Ruksha Source Type: research

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