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Source: International Journal of Medical Sciences
Cancer: Skin Cancer
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Total 31 results found since Jan 2013.
Ferumoxytol- β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype
Conclusion: The nanocomposite FMT-β-glucan suppressed melanoma growth by inducing the M1 macrophage-activated tumor microenvironment.PMID:34400883 | PMC:PMC8364471 | DOI:10.7150/ijms.61525
Source: International Journal of Medical Sciences - August 17, 2021 Category: Biomedical Science Authors: Xinghan Liu Yujun Xu Yi Li Yuchen Pan Shuli Zhao Yayi Hou Source Type: research
The Role of Melanotransferrin (CD228) in the regulation of the differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (hBM-MSC)
We examined a possible role for CD228 in the regulation of osteogenesis and adipogenesis of hBM-MSC. Surprisingly, siRNA-mediated CD228 knockdown increased the expression of the transcription factor DLX5 and enhanced osteogenesis of hBM-MSC evidenced by an increased expression of the runt-related transcription factor 2 (RUNX2), osterix (Osx), and osteocalcin (OC), as well as higher alkaline phosphatase (ALP) activity and extracellular calcium deposition. Interestingly, hBM-MSC transfected with CD228 siRNA also showed an increase in intracellular lipid level during adipogenesis, indicated by oil red O staining of differenti...
Source: International Journal of Medical Sciences - March 22, 2021 Category: Biomedical Science Authors: Maria Dubon Sooho Lee Ji-Hong Park Jae-Yong Lee Dongchul Kang Source Type: research
