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Total 23 results found since Jan 2013.

Cancers, Vol. 15, Pages 3810: Characterization of DoTc2 4510 & mdash;Identifying HPV16 Presence in a Cervical Carcinoma Cell Line Previously Considered to Be HPV-Negative
Cancers, Vol. 15, Pages 3810: Characterization of DoTc2 4510—Identifying HPV16 Presence in a Cervical Carcinoma Cell Line Previously Considered to Be HPV-Negative Cancers doi: 10.3390/cancers15153810 Authors: Nika Vučković Karin Hoppe-Seyler Angelika B. Riemer Cervical cancer is the fourth leading cause of cancer deaths in women, with over 340,000 women dying from this disease in 2020. Almost all cases have an underlying persistent infection with an oncogenic high-risk type of human papillomavirus (HPV), mainly HPV16. While cervical squamous cell carcinoma is hardly ever HPV-negative, a small subset...
Source: Cancers - July 27, 2023 Category: Cancer & Oncology Authors: Nika Vu čković Karin Hoppe-Seyler Angelika B. Riemer Tags: Article Source Type: research

Cancers, Vol. 15, Pages 2005: CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma
Conclusion: Targeting CDK4/6 can lead to improved efficacy when combined with radiation in OCSCC by inducing senescence and inhibiting DNA damage repair.
Source: Cancers - March 28, 2023 Category: Cancer & Oncology Authors: Nitisha Shrivastava Claudia Gutierrez Chavez Daniel Li Vikas Mehta Carlos Thomas Cory D. Fulcher Nicole Kawachi Danielle M. Bottalico Michael B. Prystowsky Indranil Basu Chandan Guha Thomas J. Ow Tags: Article Source Type: research

Cancers, Vol. 15, Pages 1158: Unique Metabolic Contexts Sensitize Cancer Cells and Discriminate between Glycolytic Tumor Types
nning Cancer cells utilize variable metabolic programs in order to maintain homeostasis in response to environmental challenges. To interrogate cancer cell reliance on glycolytic programs under different nutrient availabilities, we analyzed a gene panel containing all glycolytic genes as well as pathways associated with glycolysis. Using this gene panel, we analyzed the impact of an siRNA library on cellular viability in cells containing only glucose or only pyruvate as the major bioenergetic nutrient source. From these panels, we aimed to identify genes that elicited conserved and glycolysis-dependent changes in cellu...
Source: Cancers - February 11, 2023 Category: Cancer & Oncology Authors: Jonathan A. Chacon-Barahona Jeffrey P. MacKeigan Nathan J. Lanning Tags: Article Source Type: research

Cancers, Vol. 14, Pages 5363: Electroporation in Head-and-Neck Cancer: An Innovative Approach with Immunotherapy and Nanotechnology Combination
i Marco Benazzo Squamous cell carcinoma is the most common malignancy that arises in the head-and-neck district. Traditional treatment could be insufficient in case of recurrent and/or metastatic cancers; for this reason, more selective and enhanced treatments are in evaluation in preclinical and clinical trials to increase in situ concentration of chemotherapy drugs promoting a selectively antineoplastic activity. Among all cancer treatment types (i.e., surgery, chemotherapy, radiotherapy), electroporation (EP) has emerged as a safe, less invasive, and effective approach for cancer treatment. Reversible EP, using an...
Source: Cancers - October 31, 2022 Category: Cancer & Oncology Authors: Silvia Pisani Giulia Bertino Adriele Prina-Mello Laura Deborah Locati Simone Mauramati Ida Genta Rossella Dorati Bice Conti Marco Benazzo Tags: Review Source Type: research

Cancers, Vol. 14, Pages 4776: Role of the Hedgehog Pathway and CAXII in Controlling Melanoma Cell Migration and Invasion in Hypoxia
Conclusion: Our results suggest that CAXII and the Hh pathway are relevant in melanoma invasion and may be novel and promising therapeutical targets for melanoma clinical management.
Source: Cancers - September 29, 2022 Category: Cancer & Oncology Authors: Gaia Giuntini Federica Coppola Alessandro Falsini Irene Filippi Sara Monaci Antonella Naldini Fabio Carraro Tags: Article Source Type: research

Cancers, Vol. 14, Pages 3122: Cordycepin (3 & prime;-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner
Cancers, Vol. 14, Pages 3122: Cordycepin (3′-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner Cancers doi: 10.3390/cancers14133122 Authors: Su-Chan Lee Lujain Alaali HyukJean Kwon Mohammed Rigi Charles G. Eberhart Alterations in metabolism and energy production are increasingly being recognized as important drivers of neoplasia, raising the possibility that metabolic analogs could disrupt oncogenic pathways. 3′-deoxyadenosine, also known as cordycepin, is an adenosine analog that inhibits the growth of sever...
Source: Cancers - June 25, 2022 Category: Cancer & Oncology Authors: Su-Chan Lee Lujain Alaali HyukJean Kwon Mohammed Rigi Charles G. Eberhart Tags: Article Source Type: research

Cancers, Vol. 14, Pages 2151: Role of Amino Acid Transporter SNAT1/SLC38A1 in Human Melanoma
In this study, we revealed a significant upregulation of SNAT1 expression in human melanoma tissue in comparison to healthy epidermis and an increased SNAT1 expression level in human melanoma cell lines when compared to normal human melanocytes (NHEMs). We demonstrated that functional inhibition of SNAT1 with α-(methylamino) isobutyric acid (MeAIB), as well as siRNA-mediated downregulation reduces cancer cell growth, cellular migration, invasion, and leads to induction of senescence in melanoma cells. Consequently, these results demonstrate that the amino acid transporter SNAT1 is essential for cancer growth,...
Source: Cancers - April 26, 2022 Category: Cancer & Oncology Authors: Ines B öhme-Schäfer Sandra L örentz Anja Katrin Bosserhoff Tags: Article Source Type: research

Cancers, Vol. 14, Pages 1071: ADCK2 Knockdown Affects the Migration of Melanoma Cells via MYL6
Conclusion: ADCK2 affects melanoma cell motility, most probably via MYL6. Our results allow the conclusion that ADCK2 could act as a tumor suppressor in melanoma.
Source: Cancers - February 20, 2022 Category: Cancer & Oncology Authors: Marlene Vierthaler Qian Sun Yiman Wang Tamara Steinfass Juliane Poelchen Thomas Hielscher Daniel Novak Viktor Umansky Jochen Utikal Tags: Article Source Type: research

Cancers, Vol. 13, Pages 5863: IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma
T. Garrett The use of BRAF and MEK inhibitors for patients with BRAF-mutant melanoma is limited as patients relapse on treatment as quickly as 6 months due to acquired resistance. We generated trametinib and dabrafenib resistant melanoma (TDR) cell lines to the MEK and BRAF inhibitors, respectively. TDR cells exhibited increased viability and maintenance of downstream p-ERK and p-Akt as compared to parental cells. Receptor tyrosine kinase arrays revealed an increase in p-IGF1R and p-IR in the drug resistant cells versus drug sensitive cells. RNA-sequencing analysis identified IGF1R and INSR upregulated in resistant ce...
Source: Cancers - November 22, 2021 Category: Cancer & Oncology Authors: Hima Patel Rosalin Mishra Nour Yacoub Samar Alanazi Mary Kate Kilroy Joan T. Garrett Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1871: Inhibiting FAK –Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells
In conclusion, our data show that targeting FAK–paxillin interactions could be a potential therapeutic strategy to prevent metastasis formation, and molecules targeting this interface could be alternative to inhibitors of FAK kinase activity which display unexpected effects.
Source: Cancers - April 14, 2021 Category: Cancer & Oncology Authors: Antoine Mousson Marl ène Legrand Tania Steffan Romain Vauchelles Philippe Carl Jean-Pierre Gies Maxime Lehmann Guy Zuber Jan De Mey Denis Dujardin Emilie Sick Philippe Rond é Tags: Article Source Type: research

Cancers, Vol. 13, Pages 166: Molecular Targeting of HuR Oncoprotein Suppresses MITF and Induces Apoptosis in Melanoma Cells
Conclusion: HuR-NP exhibited antitumor activity in melanoma cells independent of their oncogenic B-RAF mutational status. Additionally, combinatorial therapy incorporating MEK inhibitor holds promise in overriding MITF-mediated drug resistance in melanoma.
Source: Cancers - January 6, 2021 Category: Cancer & Oncology Authors: Rebaz Ahmed Ranganayaki Muralidharan Akhil Srivastava Sarah E. Johnston Yan D. Zhao Suhendan Ekmekcioglu Anupama Munshi Rajagopal Ramesh Tags: Article Source Type: research

Cancers, Vol. 12, Pages 3527: SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells
In conclusion, IFIT2 knockdown enhances TS expression, which mediates 5-FU resistance, and SAHA pretreatment suppresses TS expression and hence sensitizes cells to 5-FU. SAHA will be an effective strategy for the treatment of OSCC patients with 5-FU resistance.
Source: Cancers - November 26, 2020 Category: Cancer & Oncology Authors: Prabha Regmi Kuo-Chu Lai Chung-Ji Liu Te-Chang Lee Tags: Article Source Type: research

Cancers, Vol. 12, Pages 2963: CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer
Kim Gareth J. Thomas Head and neck squamous cell carcinoma (HNSCC) is a heterogenous disease treated with surgery and/or (chemo) radiotherapy, but up to 50% of patients with late-stage disease develop locoregional recurrence. Determining the mechanisms underpinning treatment resistance could identify new therapeutic targets and aid treatment selection. C-terminal tensin-like (CTEN) is a member of the tensin family, upregulated in several cancers, although its expression and function in HNSCC are unknown. We found that CTEN is commonly upregulated in HNSCC, particularly HPV−ve tumours. In vitro CTEN was...
Source: Cancers - October 13, 2020 Category: Cancer & Oncology Authors: Jason C. Fleming Jeongmin Woo Karwan Moutasim Christopher J. Hanley Steven J. Frampton Oliver Wood Matthew Ward Christopher H Woelk Christian H. Ottensmeier Sassan Hafizi Dae Kim Gareth J. Thomas Tags: Article Source Type: research

Cancers, Vol. 12, Pages 908: Karyopherin- β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines
Cancers, Vol. 12, Pages 908: Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines Cancers doi: 10.3390/cancers12040908 Authors: Masaharu Hazawa Hironori Yoshino Yuta Nakagawa Reina Shimizume Keisuke Nitta Yoshiaki Sato Mariko Sato Richard W. Wong Ikuo Kashiwakura Nuclear transport receptors, such as karyopherin-β1 (KPNB1), play important roles in the nuclear-cytoplasmic transport of macromolecules. Recent evidence indicates the involvement of nuclear transport receptors in the pro...
Source: Cancers - April 7, 2020 Category: Cancer & Oncology Authors: Masaharu Hazawa Hironori Yoshino Yuta Nakagawa Reina Shimizume Keisuke Nitta Yoshiaki Sato Mariko Sato Richard W. Wong Ikuo Kashiwakura Tags: Article Source Type: research

Cancers, Vol. 12, Pages 346: WNT5A-Induced Activation of the Protein Kinase C Substrate MARCKS Is Required for Melanoma Cell Invasion
dersson WNT5A is a well-known mediator of melanoma cell invasion and metastasis via its ability to activate protein kinase C (PKC), which is monitored by phosphorylation of the endogenous PKC substrate myristoylated alanine-rich c-kinase substrate (MARCKS). However, a possible direct contribution of MARCKS in WNT5A-mediated melanoma cell invasion has not been investigated. Analyses of melanoma patient databases suggested that similar to WNT5A expression, MARCKS expression appears to be associated with increased metastasis. A relationship between the two is suggested by the findings that recombinant WNT5A (rWNT5A) induc...
Source: Cancers - February 3, 2020 Category: Cancer & Oncology Authors: Purusottam Mohapatra Vikas Yadav Maren Toftdahl Tommy Andersson Tags: Article Source Type: research