• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior
Oncotarget. 2023 Mar 21;14:219-235. doi: 10.18632/oncotarget.28388.ABSTRACTGlypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. Here, a cancer-wide GPC expression study, using clinical cancer patient data in The Cancer Genome Atlas, reveals net upregulation of GPC1 and GPC2 in primary solid tumors, whereas GPC3, GPC5 and GPC6 display lowered expression pattern compared to normal tissues. Focusing on GPC1, survival analyses of the clinical cancer patient data reveal statistically significant correlation between high expression...
Source: Oncotarget - March 21, 2023 Category: Cancer & Oncology Authors: Fang Cheng Victor Ch érouvrier Hansson Grigorios Georgolopoulos Katrin Mani Source Type: research

Transducin-like enhancer of split 3 regulates proliferation of melanoma cells via histone deacetylase activity.
In conclusion, these data indicate that Tle3 is required, at least in part, for proliferation in the B16 mouse melanoma model. PMID: 30719233 [PubMed]
Source: Oncotarget - February 7, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Constitutive activation and overexpression of NF- κB/c-Rel in conjunction with p50 contribute to aggressive tongue tumorigenesis.
In conclusion, selective participation of c-Rel with p50 that in cross-talk with AP-1/Fra-2 induced poor differentiation and aggressive tumorigenesis mainly in HPV-ve smokers while HPV infection induced expression of p65 and p27 leading to well differentiation and better prognosis preferably in non-smoking TSCC patients. PMID: 30250646 [PubMed]
Source: Oncotarget - September 27, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma.
In conclusion, the results of the present study suggested that the cytoplasm dominant expression of AQP1 is related to a poor prognosis in patients with ESCC, and that it activates tumor progression by affecting Death receptor signaling pathway. These results provide insights into the role of AQP1 as a mediator of and/or a biomarker for ESCC. PMID: 30042826 [PubMed]
Source: Oncotarget - July 27, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma.
Conclusions: The results of the present study suggest that reductions in AE2 in ESCC enhance cellular movement by activating MMP signaling pathways and are related to a poor prognosis in patients with ESCC. Methods: In human ESCC cell lines, knockdown experiments were conducted using AE2 siRNA, and the effects on cellular movement and survival were analyzed. The gene expression profiles of cells were examined using a microarray analysis. An immunohistochemical analysis was performed on 61 primary tumor samples obtained from ESCC patients who underwent esophagectomy. PMID: 29899837 [PubMed]
Source: Oncotarget - June 15, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma.
Conclusions: The present results suggest that the very strong expression of CLIC1 enhances tumor survival, while its very weak expression promotes cellular movement. The present study provides an insight into the role of CLIC1 as a switch among tumor behaviors in ESCC. PMID: 29796185 [PubMed]
Source: Oncotarget - May 31, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Identification of spleen tyrosine kinase as a potential therapeutic target for esophageal squamous cell carcinoma using reverse phase protein arrays.
Authors: Barbhuiya MA, Kashyap MK, Puttamallesh VN, Kumar RV, Wu X, Pandey A, Gowda H Abstract The vast majority of esophageal cancers in China, India and Iran are esophageal squamous cell carcinomas (ESCC). A timely diagnosis provides surgical removal as the main therapeutic option for patients with ESCC. Currently, there are no targeted therapies available for ESCC. We carried out reverse phase protein array-based protein expression profiling of seven ESCC-derivedcell lines and a non-neoplastic esophageal epithelial cell line (Het-1A) to identify differentially expressed proteins in ESCC. SYK non-receptortyrosine...
Source: Oncotarget - May 4, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Protein methyltransferases and demethylases dictate CD8+ T-cell exclusion in squamous cell carcinoma of the head and neck.
This study suggests that chromatin modifiers contribute to CD8+ T-cell exclusion and antigen presentation capacity of HPV-negative SCCHN, supporting that targeting of specific PMTs and/or PDMTs could enhance CD8+ T-cell infiltration and increase the proportion of patients that may benefit from immunotherapy. PMID: 29348866 [PubMed]
Source: Oncotarget - January 21, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Constitutive activated STAT3 is an essential regulator and therapeutic target in esophageal squamous cell carcinoma.
Authors: Tian F, Yang X, Liu Y, Yuan X, Fan T, Zhang F, Zhao J, Lu J, Jiang Y, Dong Z, Yang Y Abstract Esophageal carcinoma is among the most common cancers worldwide and a leading cause of cancer death [1]. Large numbers of studies indicated that chronic inflammation is closely associated with its development [21, 25]. Furthermore, the JAK/STAT pathway, which plays a critical role in inflammation and immunity, has been implied in a number of malignancies [11]. It has been shown that targeting the pathway affected the growth, apoptosis, and metastasis of cultured esophageal squamous cell carcinoma cells [26]. We fo...
Source: Oncotarget - November 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Melanoma antigen A12 regulates cell cycle via tumor suppressor p21 expression.
Authors: Yanagi T, Nagai K, Shimizu H, Matsuzawa SI Abstract Melanoma-associated antigen family A (MAGE-A) is a family of cancer/testis antigens that are expressed in malignant tumors but not in normal tissues other than the testes. MAGE-A12 is a MAGE-A family gene whose tumorigenic function in cancer cells remains unclear. Searches of the Oncomine and NextBio databases revealed that malignant tumors show up-regulation of MAGE-A12 mRNA relative to corresponding normal tissue. In PPC1 primary prostatic carcinoma cells and in HCT116 colorectal cancer cells (wild type and p53-depleted), MAGE-A12 gene knockdown using s...
Source: Oncotarget - August 7, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation.
Authors: Suleymanova N, Crudden C, Worrall C, Dricu A, Girnita A, Girnita L Abstract Due to its ability to compensate for signals lost following therapeutic MAPK-inhibition, insulin-like growth factor type 1 receptor (IGF-1R) co-targeting is a rational approach for melanoma treatment. However IGF-1R conformational changes associated with its inhibition can preferentially activate MAPK-pathway in a kinase-independent manner, through a process known as biased signaling. We explored the impact of biased IGF-1R signaling, on response to MAPK inhibition in a panel of skin melanoma cell lines with differing MAPK and p53 ...
Source: Oncotarget - July 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Platelet-derived growth factor-C promotes human melanoma aggressiveness through activation of neuropilin-1.
In conclusion, our results demonstrate for the first time a direct activation of NRP-1 by PDGF-C and strongly suggest that autocrine and/or paracrine stimulation of NRP-1 by PDGF-C might contribute to the acquisition of a metastatic phenotype by melanoma cells. PMID: 28700345 [PubMed - as supplied by publisher]
Source: Oncotarget - July 14, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells.
In this study, we analyzed genome-wide gene expression profiling data from 6 sensitive and 6 resistant cell lines to identify candidate genes whose expression changes are associated with responses to a MEK inhibitor, selumetinib (AZD6244). Of 62 identified differentially expressed genes, we selected Immunoglobulin Transcription Factor 2, also known as transcription factor 4 as a potential drug resistance marker for further analysis. This was because the ITF-2 expression increase in resistant cell lines was relatively high and a previous study has suggested that ITF-2 functions as an oncogene in human colon cancers. We also...
Source: Oncotarget - June 4, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Pages: 1  2  3