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Cancer: Myeloma
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Inhibition of VCP modulates NF- κB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation
This study aims to identify if VCP is a therapeutic target in MM and confirm the effect of a novel inhibitor of VCP (VCP20) on MM. We found that VCP was elevated in MM patients and correlated with shorter survival in clinical TT2 cohort. Silencing VCP using siRNA resulted in decreased MM cell proliferation via NF-κB signaling pathway. VCP20 evidently inhibited MM cell proliferation and osteoclast differentiation. Moreover, exosomes containing VCP derived from MM cells partially alleviated the inhibitory effect of VCP20 on cell proliferation and osteoclast differentiation. Mechanism study revealed that VCP20 inactivated th...
Source: Cancer Control - August 22, 2023 Category: Cancer & Oncology Authors: Rongfang Wei Yuhao Cao Hongjie Wu Xin Liu Mingmei Jiang Xian Luo Zhendong Deng Ze Wang Mengying Ke Yongqiang Zhu Siqing Chen Chunyan Gu Ye Yang Source Type: research
