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Involvement of RUVBL1 in WNT/ < em > β < /em > -Catenin Signaling in Oral Squamous Cell Carcinoma
Dis Markers. 2022 Apr 22;2022:3398492. doi: 10.1155/2022/3398492. eCollection 2022.ABSTRACTOral squamous cell carcinoma (OSCC) is the most common malignant tumor of head and neck squamous cell carcinoma (HNSCC), but the causes and molecular mechanisms remain unclear. The wingless-integrated/β-catenin (WNT/β-catenin) signaling pathway plays a vital role in cancer cell proliferation, differentiation, and metastasis, including OSCC. To screen potential β-catenin-associated genes involved in OSCC, the intersection of these genes in the STRING and IMEx databases was assessed using differential expression genes (DEG) from pub...
Source: Disease Markers - May 2, 2022 Category: Laboratory Medicine Authors: Yongfa Zeng Ying Kong Lan Liao Hongshui Zhu Source Type: research

An Oncogenic Role for Four-Jointed Box 1 (FJX1) in Nasopharyngeal Carcinoma.
Authors: Chai SJ, Ahmad Zabidi MM, Gan SP, Rajadurai P, Lim PVH, Ng CC, Yap LF, Teo SH, Lim KP, Patel V, Cheong SC Abstract Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer prevalent in Southern China and Southeast Asia. The current knowledge on the molecular pathogenesis of NPC is still inadequate to improve disease management. Using gene expression microarrays, we have identified the four-jointed box 1 (FJX1) gene to be upregulated in primary NPC tissues relative to nonmalignant tissues. An orthologue of human FJX1, the four-jointed (fj) gene in Drosophila and Fjx1 in mouse, has reported to be associa...
Source: Disease Markers - June 28, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research