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Cancer: Small Cell Lung Cancer
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Cancers, Vol. 13, Pages 1187: Molecular Signature of Small Cell Lung Cancer after Treatment Failure: The MCM Complex as Therapeutic Target
In this study, we identified a gene expression signature of SCLC after treatment failure using SCLC clinical specimens (GEO accession number: GSE162102). A total of 1,136 genes were significantly upregulated in SCLC tissues. These upregulated genes were subjected to KEGG pathway analysis, and “cell cycle”, “Fanconi anemia”, “alcoholism”, “systemic lupus erythematosus”, “oocyte meiosis”, “homologous recombination”, “DNA replication”, and “p53 signaling” were identified as the enriched pathways among the genes. We focused on the cell cycle pathway and investigated the clinical significance of ...
Source: Cancers - March 10, 2021 Category: Cancer & Oncology Authors: Shunsuke Misono Keiko Mizuno Takayuki Suetsugu Kengo Tanigawa Nijiro Nohata Akifumi Uchida Hiroki Sanada Reona Okada Shogo Moriya Hiromasa Inoue Naohiko Seki Tags: Article Source Type: research
