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Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation
Eur J Pharmacol. 2022 Aug 15:175208. doi: 10.1016/j.ejphar.2022.175208. Online ahead of print.ABSTRACTNon-small cell lung cancer (NSCLC) has the highest incidence and mortality in the world. Aspirin has been reported to promote apoptosis, inhibit proliferation, stemness, angiogenesis, cancer-associated inflammation and migration in NSCLC. But the effect of aspirin on aerobic glycolysis in NSCLC is less reported. In the present study, we investigated whether aspirin blocked aerobic glycolysis of NSCLC cell to inhibit proliferation. Our results showed that aspirin inhibited viability, PCNA expression, ability of colony forma...
Source: European Journal of Pharmacology - August 18, 2022 Category: Drugs & Pharmacology Authors: Guanghui Ren Yan Ma Xingjie Wang Zhaodi Zheng Guorong Li Source Type: research

Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug
Conclusions: Cumulatively, these results signify a crucial role of the anti-inflammatory agent aspirin as a novel negative regulator of epithelial-to-mesenchymal transition thereby suggesting its candidature as a promising tool for deterring metastasis of highly invasive K-ras-expressing NSCLC cells.
Source: Epidemiologic Perspectives and Innovations - January 26, 2016 Category: Epidemiology Authors: Poulami KhanArgha MannaShilpi SahaSuchismita MohantyShravanti MukherjeeMinakshi MazumdarDeblina GuhaTanya Das Source Type: research