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Source: Cancer Research
Cancer: Liver Cancer

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Total 22 results found since Jan 2013.

Abstract B43: Dose and context-dependent roles for Arid1a in liver tumorigenesis
Frequent Arid1a loss-of-function mutations suggest tumor suppressive roles, but the functional impact of Arid1a and SWI/SNF chromatin-remodeling aberrations in human cancer are not clear. Liver-specific Arid1a knockout mice do not develop cancer after 15 months and surprisingly, homozygous mice are potently protected from diethylnitrosamine (DEN) + carbon tetrachloride induced hepatocellular carcinoma (HCC). This is likely due to the fact that Arid1a deficient livers are resistant to chemical damage in a Cytochrome P450 dependent fashion. To determine if genetic drivers of cancer might reveal additional roles for Arid1a, w...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Sun, X., Wang, S., Nguyen, L., Zhu, H. Tags: Epigenetic Cancer Therapies Source Type: research

Abstract 1671: Fibroblast growth factor receptor 3 enhances progression of hepatocellular carcinoma
Conclusions: Upregulated FGFR3 is associated with development and progression of hepatocellular carcinoma. Accordingly, blockade of FGFR3-mediated signaling may be a promising therapeutic approach to antagonize growth and malignant behavior of HCC cells.Citation Format: Jakob Paur, Lisa Nika, Christiane Maier, Julia Kostka, Petra Heffeter, Sonja Kappel, Daniela Kandioler, Klaus Holzmann, Brigitte Marian, Walter Berger, Michael Grusch, Bettina Grasl-Kraupp. Fibroblast growth factor receptor 3 enhances progression of hepatocellular carcinoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Paur, J., Nika, L., Maier, C., Kostka, J., Heffeter, P., Kappel, S., Kandioler, D., Holzmann, K., Marian, B., Berger, W., Grusch, M., Grasl-Kraupp, B. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 1942: Regulation of GRNMB transcription and cellular effects by chondroitin 4-sulfation
Increased expression of glycoprotein (transmembrane) NMB (GPNMB; osteoactivin) has been identified in triple negative breast cancer, melanoma, glioma, and hepatocellular carcinoma, and followed decline in expression of the enzyme arylsulfatase B (ARSB; N-acetylgalactosamine 4-sulfatase). The expression and regulation of GPNMB was evaluated in HepG2 cells and in ARSB-deficient and control C57BL/6J mouse hepatic tissue. Increased expression of GPNMB was attributable to promoter activation by phospho(Ser)MITF (microphthalmia-associated transcription factor), the phosphorylation of which was activated by phospho(Ser)-p38 MAPK....
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Tobacman, J. K., Feferman, L., Bhattacharyya, S. Tags: Molecular and Cellular Biology Source Type: research

Abstract 2732: The role of protein P in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the third leading cause of cancer-related death worldwide. Although treatment options have improved in the past 30 years, 5-year survival rate remains below 20%. To improve the therapeutics of HCC, great efforts are needed in understanding the mechanisms underlying HCC. Protein P, plays an important role in the development of cancer. To clarify the role of P in the development of HCC, we investigated the expression level of P in HCC tissue chips. The results showed that P level is much higher in carcinoma than adjacent tissue, and the overall 5-year surv...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Fu, H., Guo, L., HUANG, L. Tags: Carcinogenesis Source Type: research

Abstract 2045: Sleeping Beauty mutagenesis screening identifies a novel tumor suppressor gene involved in liver tumor development
Conclusion: RNF125 gene is a novel tumor suppressor gene for human HCC and plays an important role in cellular proliferation. RNF125 gene is frequently inactivated in human HCC and therefore its functional recovery could be a potential therapeutic target of HCC.Citation Format: Takahiro Kodama, Zhubo Wei, Michiko Kodama, Nancy Jenkins, Neal Copeland. Sleeping Beauty mutagenesis screening identifies a novel tumor suppressor gene involved in liver tumor development. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AAC...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Kodama, T., Wei, Z., Kodama, M., Jenkins, N., Copeland, N. Tags: Molecular and Cellular Biology Source Type: research

Abstract 814: Truncated HBx-dependent silencing of growth arrest-specific 2 promotes hepatocarcinogenesis through inhibition of p53-mediated apoptosis
In conclusion, our integrated study uncovered a novel viral mechanism in hepatocarcinogenesis, wherein HBxΔ35 ablates p53-driven apoptosis via direct silencing of GAS2, and thereby provides survival advantage for pre-neoplastic hepatocytes to facilitate cancer development.Citation Format: Alfred S. L. Cheng, Ranxu Zhu, Myth T.S. Mok, Wai Kang, Ka-Fai To, Joseph J.Y. Sung, Henry L.Y. Chan. Truncated HBx-dependent silencing of growth arrest-specific 2 promotes hepatocarcinogenesis through inhibition of p53-mediated apoptosis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Rese...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Cheng, A. S. L., Zhu, R., Mok, M. T. S., Kang, W., To, K.-F., Sung, J. J. Y., Chan, H. L. Y. Tags: Carcinogenesis Source Type: research

Abstract 5400: A novel combinatorial therapy for hepatocellular carcinoma (HCC)
The incidence of hepatocellular carcinoma (HCC) is rising in the US with parallel increase in mortality rate. Lack of effective therapy for advanced HCC mandates development of novel targeted therapies to counteract this fatal malady. Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH) and LYRIC, plays a pivotal role in hepatocarcinogenesis and serves as an ideal target for anti-HCC therapy. AEG-1 interacts with retinoid X receptor (RXR) and inhibits retinoic acid-induced gene expression and cell death. Retinoic acid has been evaluated for HCC treatment without promising result. Overexpression of AEG-1 might...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Srivastava, J., Rajasekaran, D., Siddiq, A., Gredler, R., Robertson, C. L., Akiel, M. A., Shen, X.-N., Ebeid, K. A. N., Salem, A. K., Fisher, P. B., Sarkar, D. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 1371: Systems biology analysis to identify biomarkers for lenvatinib in the preclinical cancer cell line panels
Objectives: Lenvatinib mesilate (lenvatinib) is the selective inhibitor of VEGFR1-3, and other proangiogenic and oncogenic pathway-related RTKs including fibroblast growth factor receptors (FGFR1-4), the platelet-derived growth factor receptor (PDGFR) α, KIT, and RET. Lenvatinib have been tested in several clinical trials, such as thyroid cancer and hepatocellular carcinoma in Ph3, but biomarkers to predict lenvatinib activity were not established. We performed a preclinical systems biology approach to identify biomarkers predictive of lenvatinib sensitivity in endometrial cell lines.Methods: We performed gene expression ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Dezso, Z., Ino, M., Minoshima, Y., Tohyama, O., Sugi, N. H., Agoulnik, S., Oda, Y., Funahashi, Y. Tags: Tumor Biology Source Type: research

Abstract 26: Suppression of E-cadherin mediates gallotannin-induced apoptosis in Hep G2 hepatocelluar carcinoma cells
Though gallotannin was known to have anti-oxidant and antitumor activity, the underlying antitumor mechanism of gallotannin still remains unclear. Thus, in the present study, antitumor mechanism of gallotannin was elucidated in hepatocellular carcinoma cells. Gallotannin significantly exerted cytotoxicity against Hep G2 and Chang hepatocellular carcinoma cells with the accumulation of the sub-G1 population and increase of terminal deoxynucleotidyltransferasedUTP nick end labeling (TUNEL) positive cells as an apoptotic feature. Also, gallotannin attenuated the expression of pro-caspase9, pro-caspase3, Bcl2 and integrin β1 ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Kwon, H. Y., Jung, J. H., Lee, H. J., Jeong, M. S., Jung, D.-B., Kim, B., Lee, H., Kim, S.-H. Tags: Molecular and Cellular Biology Source Type: research

Abstract 537: Toll-like receptor (TLR3) signaling in human hepatocellular carcinoma (HCC) depends on the tumor-associated long-noncoding RNA H19
HCC is the third leading cause of cancer-related mortality worldwide. Metabolic syndrome diseases are shown to facilitate the progression of HCC in industrial countries. Recent studies unraveled pivotal roles of long non-coding RNAs (lncRNAs) in carcinogenesis and cancer metastasis. The controversy that the non-translated H19 mRNA harbors pro- as well as anti-tumorigenic potential shows that its function is poorly characterized. TLR3 plays a key role in the recognition of exogenous pathogen-associated dsRNA and even more importantly TLR3 is activated by endogenous injury-associated ligands. There is increasing evidence tha...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Paulus, P., Urbschat, A., Reissig, C., Zacharowski, K., Drose, S., Scheller, B., Tybl, E. Tags: Molecular and Cellular Biology Source Type: research

Abstract 112: Synthesis and preclinical evaluation of radiolabeled alisertib as an investigational aurora kinase A PET tracer
Conclusions: Both [3H]alisertib and [11C]alisertib were obtained with good purity and yield. In vitro studies using [3H]alisertib indicate good correlation of cellular uptake with AURKA expression. [11C]alisertib is stable in vivo and HCT116 xenografted mice show a fair tumor uptake of [11C]alisertib. Citation Format: Joost Verbeek, Jeroen ACM Goos, Albert A. Geldof, Annemieke C. Hiemstra, Otto S. Hoekstra, Gerrit A. Meijer, Steven Stroud, Daniel Bradley, Remond JA Fijneman, Albert D. Windhorst. Synthesis and preclinical evaluation of radiolabeled alisertib as an investigational aurora kinase A PET tracer. [abstract]. In: ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Verbeek, J., Goos, J. A., Geldof, A. A., Hiemstra, A. C., Hoekstra, O. S., Meijer, G. A., Stroud, S., Bradley, D., Fijneman, R. J., Windhorst, A. D. Tags: Cancer Chemistry Source Type: research

Abstract 2923: Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
MAPK7/ERK5 (extracellular-signal-regulated kinase 5) is the effector kinase of a canonical three-tiered MAPK (mitogen activated protein kinase) signalling cascade comprising MEK (MAPK/ERK kinase) 5, MEKK(MEK kinase) 2/3 and ERK5 itself(1). Under normal physiological conditions, MEK5 and ERK5 are ubiquitously expressed and are activated by growth factors and cellular stresses to perform roles in blood vessel, cardiac and muscle development(2). Although the MAPK7-axis is the least well studied of the MAPK-signaling pathways, evidence suggests that it plays a role in the pathology of cancer, in particular; breast cancer progr...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Gavine, P. R., Wang, M., Yu, D., Hu, E., Huang, C., Xia, J., Su, X., Fan, J., Zhang, T., Ye, Q., Zheng, L., Xie, L., Han, L., Zhu, G., Qian, Z., Luo, Q., Hou, Y., Ji, Q. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 1148: Epithelial to mesenchymal transition might be induced via CD44 isoform switch in colorectal cancer
We examined the association between the EMT status and CD44 isoform switch, and analyzed the correlation with clinicopathological factors and prognosis. Finally, we evaluated the effect of CD44 knockdown by siRNA in CRC cell lines by measuring the proliferation, migration and invasion ability. Results: 1. The CRC cell lines were classified into 8 epithelial, 4 mesenchymal and 2 intermediate type. Of these cell lines, CD44s was highly expressed in mesenchymal type cell lines, whereas, CD44v9 was highly expressed in epithelial type cell lines. 2. The 150 CRC patients were divided into 115 epithelial group and 35 mesenchymal ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Mashita, N., Yamada, S., Iwata, N., Kanda, M., Kobayashi, D., Tanaka, C., Fujii, T., Nakayama, G., Sugimoto, H., Koike, M., Nomoto, S., Fujiwara, M., Kodera, Y. Tags: Tumor Biology Source Type: research

Abstract 2003: CPE-delta-N promotes metastasis by regulating Nedd9 and Yap1 expression
We report here that the carboxypeptidase E gene (CPE) is alternatively spliced in human tumors to yield an N-terminal truncated protein (CPE-DELTA-N) that drives metastasis. CPE-DELTA-N mRNA was elevated in human metastatic colon, breast and HCC cell lines. Suppression of CPE-DELTA-N expression in these cell lines by si-RNA significantly inhibited their growth migration and invasion. To confirm these observations in vivo, an orthotopic nude mouse model was established. The mice implanted with a tumor derived from HCC cells transfected with si- CPE-DELTA-N RNA in the liver did not show tumor growth or metastasis, compared t...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Murthy, S. R. K., Lee, T. K., Cawley, N. X., Hewitt, S. M., Loh, P. Y. Tags: Tumor Biology Source Type: research

Abstract 501: CXCR4 induced ROS accumulation through PI3K/AKT
Reactive oxygen species (ROS) and oxidative stress have long been implicated in the onset and progression of many cancers. A mechanism by which ROS contributes to cancer is by relaying signals from the cell surface to important signaling proteins, thereby regulating a variety of cellular processes. Identifying the sources of ROS in cancer cells, and the consequences of oxidative stress, remain areas of intense research. We have previously demonstrated that ROS increased expression and activity of the chemokine (CXC) receptor, type 4 (CXCR4), which resulted in trans-endothelial migration of prostate cancer (PCa) cells. Simi...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Bryant, L. K., Jones, K. J., Hinton, C. V. Tags: Molecular and Cellular Biology Source Type: research