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Condition: Multidrug Resistance
Cancer: Bile Duct Cancer
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Total 2 results found since Jan 2013.
Enhanced expression of ten ‐eleven translocation 1 reverses gemcitabine resistance in cholangiocarcinoma accompanied by a reduction in P‐glycoprotein expression
This study demonstrated that TET1 expression reverses gemcitabine resistance in CCA accompanied by a reduction in P ‐gp expression. Thus, TET1 may be a promising target to overcome the chemoresistance in CCA. AbstractIncreasing evidence revealed that ten ‐eleven translocation 1 (TET1) plays an important role in tumorigenesis and chemoresistance, but its functions in gemcitabine resistance in cholangiocarcinoma (CCA) remain unknown. This study aims to investigate the effect of TET1 on gemcitabine resistance in CCA and the possible effect on P‐gly coprotein (P‐gp) expression encoded by multidrug resistance (MDR) gene...
Source: Cancer Medicine - February 19, 2019 Category: Cancer & Oncology Authors: Chuanxu Wang,
Hua Ye,
Lei Zhang,
Yayu Cheng,
Shifeng Xu,
Ping Zhang,
Zijie Zhang,
Jimin Bai,
Fangkang Meng,
Lin Zhong,
Guangjun Shi,
Hao Li Tags: ORIGINAL RESEARCH Source Type: research
