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Bakuchiol exhibits anti-metastasis activity through NF-κB cross-talk signaling with AR and ERβ in androgen-independent prostate cancer cells PC-3
Publication date: Available online 16 June 2017Source: Journal of Pharmacological SciencesAuthor(s): Lin Miao, Xiaoting Yun, Rui Tao, Yuefei Wang, Xiumei Gao, Guanwei Fan, Yan Zhu, Ting Cai, Zhipeng Zhu, Chunlin YanAbstractAndrogen-independent prostate cancer (PCa) is a developed tumor derived from the local androgen dependent PCa, which often affects elderly men. Psoralea corylifolia L, a traditional Chinese medicine, has been widely used for PCa treatment as an important part of a common prescription, while the mechanism remains unclear. Our study was aimed to investigate the tumor-inhibitory effect of its main component...
Source: Journal of Pharmacological Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a.
Abstract Most prostate cancers initially respond to androgen deprivation therapy, but then progress from androgen-dependent to androgen-independent prostate cancers. In the present study, a differential cytotoxicity screen of hormone-resistant prostate cancer LNCaP-hr cells and the parental LNCaP-FGC cells against normal MRC5 fibroblast cells, identified a small molecule compound, Aristeromycin (a derivative of 3-deazaneplanocin A (DZNeP)). The molecular target was shown to be S-adenosylhomocysteine hydrolase (AHCY), which catalyzes reversible hydrolysis of S-adenosylhomocysteine (SAH) to adenosine and L-homocyste...
Source: European Journal of Pharmacology - July 10, 2017 Category: Drugs & Pharmacology Authors: Uchiyama N, Tanaka Y, Kawamoto T Tags: Eur J Pharmacol Source Type: research

Bakuchiol exhibits anti-metastasis activity through NF- κB cross-talk signaling with AR and ERβ in androgen-independent prostate cancer cells PC-3
Publication date: Available online 16 June 2017 Source:Journal of Pharmacological Sciences Author(s): Lin Miao, Xiaoting Yun, Rui Tao, Yuefei Wang, Xiumei Gao, Guanwei Fan, Yan Zhu, Ting Cai, Zhipeng Zhu, Chunlin Yan Androgen-independent prostate cancer (PCa) is a developed tumor derived from the local androgen dependent PCa, which often affects elderly men. Psoralea corylifolia L, a traditional Chinese medicine, has been widely used for PCa treatment as an important part of a common prescription, while the mechanism remains unclear. Our study was aimed to investigate the tumor-inhibitory effect of its main component baku...
Source: Journal of Pharmacological Sciences - June 16, 2017 Category: Drugs & Pharmacology Source Type: research