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Abstract A16: Different epigenetic mechanisms involved in the regulation of SFRP1 gene in prostate cancer
Among men, prostate cancer (PCa)[1] is the second most common cancer and the fifth cause of death worldwide [2]. Androgens play an important role in the development of the disease. For advanced PCa the standard therapy is androgen depletion. However, after 2 or 3 years a high percentage of patients become resistant to this therapy and castration resistant prostate cancer (CRPC) is developed. There is no successful treatment for CRPC, leading into death [3, 4]. Wingless pathway (WNT) is aberrantly activated in several cancer types and in PCa it is involved in AR activity modulation, promoting cancer development [5]. Secrete...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Garcia–Tobilla, P., Uribe, O., Rodriguez–Dorantes, M. Tags: Epigenetic Control of Transcription/ Elongation Source Type: research

Abstract 1956: A subset of prostate cancer cells with loss of MST1 expression confers resistance to castration through YAP1-AR interactions
In conclusion, our findings suggest that the Hippo-YAP1-AR signaling axis is one of the key mechanisms for metastatic PC progression and may represent as a promising therapeutic target for patients with the lethal disease.Note: This abstract was not presented at the meeting.Citation Format: Bekir Cinar, Gamze Kuser Abali, Michael Lewis, Colm Morrissey, Isla Garraway. A subset of prostate cancer cells with loss of MST1 expression confers resistance to castration through YAP1-AR interactions. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia,...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Cinar, B., Kuser Abali, G., Lewis, M., Morrissey, C., Garraway, I. Tags: Molecular and Cellular Biology Source Type: research

Abstract 1964: Role of AMP kinase in TRAIL and PPAR{gamma} ligand combination-induced apoptosis and {beta}-catenin cleavage
In this study we found that TRAIL-TZD-induced β-catenin cleavage also involves AMPK. Knockdown of AMPKα showed strong reduction of the cleaved β-catenin product in both cell types. Since TZD is an agonist of PPARγ, we also determined its involvement in this apoptosis pathway. Endogenous expression of PPARγ showed significant differences between DU145 and LNCaP cells, with higher level expression in the DU145 cells. Knockdown of PPARγ in DU145 cells showed a reduction of cleaved caspase 3 levels whereas cleaved caspase 8, 9 and PARP levels were largely unaffected. Luciferase assays with PPARγ-responsive reporter (PPR...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Santha, S., Basu, A., Rana, A., Rana, B. Tags: Molecular and Cellular Biology Source Type: research