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Specialty: Urology & Nephrology
Cancer: Hormone Refractory Prostate Cancer
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Total 1 results found since Jan 2013.
A novel hydroxysuberamide derivative potentiates MG132‐mediated anticancer activity against human hormone refractory prostate cancers—the role of histone deacetylase and endoplasmic reticulum stress
CONCLUSIONSThe data suggest that WJ25591 inhibited HDAC activity, leading to cell‐cycle arrest and inhibition of DNA repair. Caspase cascades are subsequently triggered to execute cell apoptosis. MG‐132 dramatically sensitizes WJ25591‐mediated apoptosis, at least partly, through ER stress response. The data also reveal that combination of HDAC inhibitors and proteasome inhibitors may be a potential strategy against hormone‐refractory prostate cancers. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - June 28, 2013 Category: Urology & Nephrology Authors: Yi‐Cheng Chen, Wei‐Jan Huang, Jui‐Ling Hsu, Chia‐Chun Yu, Wei‐Ting Wang, Jih‐Hwa Guh Tags: Original Article Source Type: research
