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Antitumor effects of interleukin‐6 (IL‐6)/interleukin‐6 receptor (IL‐6R) signaling pathway inhibition in clear cell carcinoma of the ovary
In this study, we aim to clarify whether IL‐6/IL‐6R mediated signaling pathway could have clinical relations with CCC and to evaluate inhibitory effects of the pathway on CCC carcinogenesis. A total of 84 CCC cases collected from primary surgical specimens were evaluated by the immunohistochemical analysis for IL‐6R and phosphorylated Stat3 (pStat3), and we found that high IL‐6R expression correlated with poor patient survival both by the univariate and multivariate analyses, suggesting that IL‐6/IL‐6R signaling pathway could be implicated in the progression of CCC. We further investigated the effects of IL‐6...
Source: Molecular Carcinogenesis - April 10, 2015 Category: Molecular Biology Authors: Nozomu Yanaihara, Yukihiro Hirata, Noriko Yamaguchi, Yukiko Noguchi, Misato Saito, Chie Nagata, Satoshi Takakura, Kyosuke Yamada, Aikou Okamoto Tags: Research Article Source Type: research

Hypoxia regulates the sperm associated antigen 4 (SPAG4) via HIF, which is expressed in renal clear cell carcinoma and promotes migration and invasion in vitro
Abstract Hypoxia leads to the upregulation of a variety of genes mediated largely via the hypoxia inducible transcription factor (HIF). Prominent HIF‐regulated target genes such as the vascular endothelial growth factor (VEGF), the glucose transporter 1 (Glut‐1), or erythropoietin (EPO) help to assure survival of cells and organisms in a low oxygenated environment. Here, we are the first to report the hypoxic regulation of the sperm associated antigen 4 (SPAG4). SPAG4 is a member of the cancer testis (CT) gene family and to date little is known about its physiological function or its involvement in tumor biology. A num...
Source: Molecular Carcinogenesis - July 2, 2013 Category: Molecular Biology Authors: Karl Xaver Knaup, Juliana Monti, Thomas Hackenbeck, Tilmann Jobst‐Schwan, Bernd Klanke, Ruth Elisabeth Schietke, Ingrid Wacker, Juergen Behrens, Kerstin Amann, Kai‐Uwe Eckardt, Christina Warnecke, Michael Sean Wiesener Tags: Research Article Source Type: research