Filtered By:
Specialty: Chemistry
Cancer: Serous Carcinoma
This page shows you your search results in order of date.
Order by Relevance | Date
Total 1 results found since Jan 2013.
Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17 Membrane Biology
We report that ADAM17 and ADAM10 cleave Nectin-4 and release soluble Nectin-4 (sN4). Small molecule inhibitors and siRNA knockdown of both ADAM proteases confirmed these results. In matched samples from 11 high-grade serous ovarian cancer patients, we detected 2–20-fold more sN4 in ascites fluid than serum. Co-incubation of ovarian cancer cells with ascites fluid significantly increased sN4 shedding, which could be blocked using a dual inhibitor of ADAM10 and ADAM17. Furthermore, we detected RNA for Nectin-4, ADAM10, and ADAM17 in primary ovarian carcinoma tumors, secondary omental metastases, and ascites cells isolated ...
Source: Journal of Biological Chemistry - April 14, 2017 Category: Chemistry Authors: Petra C. Buchanan, Kristin L. M. Boylan, Bruce Walcheck, Rachel Heinze, Melissa A. Geller, Peter A. Argenta, Amy P. N. Skubitz Tags: Cell Biology Source Type: research
