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Inhibition of RNA-Binding Protein Musashi-1 Suppresses Malignant Properties and Reverses Paclitaxel Resistance in Ovarian Carcinoma
Conclusions: These findings suggest that MSI-1 overexpression is associated with the prognosis of OC patients, and knockdown of MSI-1 can suppress malignant properties and reverse paclitaxel-resistance in OC cells. MSI-1 maybe act as a potential prognostic indicator and a therapeutic target in OC.
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Huaizeng Chen, Jia Liu, Hanzhi Wang, Qi Cheng, Caiyun Zhou, Xiaojing Chen, Feng Ye Tags: Research Paper Source Type: research

Abstract 2387: Interplay between Aurora A kinase and BRCA1 promotes genetic stability
Ovarian cancer accounts for 5% of all female cancer-related deaths, more than any other reproductive cancer. Of the various histological subtypes, high-grade serous carcinoma is the most common. Mutations in BRCA1/BRCA2, which are associated with familial predisposition, are present in 10% of cases, while TCGA data demonstrates that P53 is mutated in 96% of high-grade serous ovarian carcinomas. In addition to aberrant P53 expression, severe aneuploidy with a near polyploid number of chromosomes is the only other genetic abnormality associated with these tumors. Ploidy changes occur early in tumor development, suggesting th...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Marion, C. M., Yu, V., Dubeau, L. Tags: Molecular and Cellular Biology Source Type: research