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Syndecan-1 and -4 influence Wnt signaling and cell migration in human breast cancers
This study examined syndecan-1 (SDC1) and syndecan-4 (SDC4; SDC1/4) in breast cancer (BC) in vitro cell models and their role in tumorigenesis. Gene expression of HSPG core proteins, biosynthesis and modification enzymes along with Wnt/FGF morphogen pathway components were examined following inhibition of SDC1 and SDC4 via small interfering RNA (siRNA), and enhancement of HSPGs via addition of heparin and FGF. siRNAs knockdowns (KDs) were performed in the MCF-7 (lowly invasive and poorly metastatic) and the MDA-MB-231 (highly invasive and metastatic) human BC cell lines. Significantly decreased gene expression of SDC1 and ...
Source: Biochimie - February 20, 2022 Category: Biochemistry Authors: Son H Pham Kaylah Pratt Rachel K Okolicsanyi Lotta E Oikari Chieh Yu Ian W Peall Km Taufiqul Arif Te-Arn Chalmers Martina Gyimesi Lyn R Griffiths Larisa M Haupt Source Type: research