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Total 34564 results found since Jan 2013.
Therapeutic effects of human monoclonal PSMA antibody-mediated TRIM24 siRNA delivery in PSMA-positive castration-resistant prostate cancer
Conclusion: PSMAb mediated TRIM24 siRNA delivery platform could significantly inhibit cell proliferation, colony-formation, and invasion in PSMA+ CRPC in vitro and suppressed tumor growth and bone loss in PSMA+ CRPC xenograft and bone metastasis model.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Sheng-Jia Shi, Li-Juan Wang, Dong-Hui Han, Jie-Heng Wu, Dian Jiao, Kai-Liang Zhang, Jiang-Wei Chen, Yu Li, Fa Yang, Jing-Liang Zhang, Guo-Xu Zheng, An-Gang Yang, Ai-Zhi Zhao, Wei-Jun Qin, Wei-Hong Wen Tags: Research Paper Source Type: research
Antidepressants for hip and knee osteoarthritis
CONCLUSIONS: There is high-certainty evidence that use of antidepressants for knee osteoarthritis leads to a non-clinically important improvement in mean pain and function. However, a small number of people will have a 50% or greater important improvement in pain and function. This finding was consistent across all trials. Pain in osteoarthritis may be due to a variety of causes that differ between individuals. It may be that the cause of pain that responds to this therapy is only present in a small number of people. There is moderate-certainty evidence that antidepressants have a small positive effect on quality of life w...
Source: Cochrane Database of Systematic Reviews - October 21, 2022 Category: General Medicine Authors: Alexandra A Leaney Jenna R Lyttle Julian Segan Donna M Urquhart Flavia M Cicuttini Louisa Chou Anita E Wluka Source Type: research
Multiphase preclinical assessment of a novel device to locate unintentionally retained surgical sharps: a proof-of-concept study
CONCLUSIONS: The use of MSF in this study's RSS models facilitated the determination of presence and localization of RSS as shown by the increased rate of identification of a needle, decreased time to identification and higher accuracy in determining the presence of a needle. This device may be used in conjunction with radiography as it gives live visual and auditory feedback for users during the search for RSS.PMID:37101230 | DOI:10.1186/s13037-023-00359-8
Source: Patient Safety in Surgery - April 26, 2023 Category: Surgery Authors: Hae Sung Kang Jad Khoraki Jessie Gie Dielle Duval Susan Haynes Michael Siev Jay Shah Fernando Kim Martin Mangino Levi Procter Riccardo Autorino Samuel Weprin Source Type: research
