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Total 1090 results found since Jan 2013.

Molecules, Vol. 28, Pages 6696: Antiviral Effect of 5 & prime;-Arylchalcogeno-3-aminothymidine Derivatives in SARS-CoV-2 Infection
Molecules, Vol. 28, Pages 6696: Antiviral Effect of 5′-Arylchalcogeno-3-aminothymidine Derivatives in SARS-CoV-2 Infection Molecules doi: 10.3390/molecules28186696 Authors: Amanda Resende Tucci Raquel Mello da Rosa Alice Santos Rosa Otávio Augusto Chaves Vivian Neuza Santos Ferreira Thamara Kelcya Fonseca Oliveira Daniel Dias Coutinho Souza Nathalia Roberto Resende Borba Luciano Dornelles Nayra Salazar Rocha João Candido Pilar Mayer João B. Teixeira da Rocha Oscar Endrigo D. Rodrigues Milene Dias Miranda The understanding that zidovudine (ZDV or azidothymidine, AZT) inhibits t...
Source: Molecules - September 19, 2023 Category: Chemistry Authors: Amanda Resende Tucci Raquel Mello da Rosa Alice Santos Rosa Ot ávio Augusto Chaves Vivian Neuza Santos Ferreira Thamara Kelcya Fonseca Oliveira Daniel Dias Coutinho Souza Nathalia Roberto Resende Borba Luciano Dornelles Nayra Salazar Rocha Jo ão Candido Tags: Article Source Type: research

Molecules, Vol. 28, Pages 6666: Dendritogenic Potential of the Ethanol Extract from Lippia alba Leaves in Rat Cortical Neurons
lbarracin A reduced dendritic complexity, especially in regions such as the hippocampus and the prefrontal cortex, has been linked to the pathophysiology of some neuropsychiatric disorders, in which synaptic plasticity and functions such as emotional and cognitive processing are compromised. For this reason, the identification of new therapeutic strategies would be enriched by the search for metabolites that promote structural plasticity. The present study evaluated the dendritogenic potential of the ethanol extract of Lippia alba, an aromatic plant rich in flavonoids and terpenes, which has been widely used in traditi...
Source: Molecules - September 16, 2023 Category: Chemistry Authors: Mar ía Marcela Velásquez Mar ía Claudia Lattig Luis Carlos Chitiva Geison M. Costa Jhon Jairo Sutachan Sonia Luz Albarracin Tags: Article Source Type: research

Molecules, Vol. 28, Pages 6642: Talaromyces sp. Ethyl Acetate Crude Extract as Potential Mosquitocide to Control Culex pipiens quinquefasciatus
In this study, a high-throughput screening method was used to search for potential mosquitocides in the Global Fungal Extract Library (GFEL). We tested the larvicidal activity of 264 fungal ethyl acetate crude extracts against Culex pipiens quinquefasciatus. Nine fungal extracts caused moderate to high mortality rates (>50%), with two fungal extracts (58A7 and 101H12) causing a 100% mortality rate. The lethal concentrations for 50% of the population (LC50) were 44.27 mg/L and 31.90 mg/L, respectively. Fraction 14 had a high mortality rate, with an LC50 value of 12.13 mg/L, and was isolated from 58A7 (Fractions 1...
Source: Molecules - September 15, 2023 Category: Chemistry Authors: Junhui Chen Zhiyong Xu Yangqing Liu Feiying Yang Limei Guan Jian Yang Jianghuai Li Guodong Niu Jun Li Liang Jin Tags: Article Source Type: research

Molecules, Vol. 28, Pages 6604: Could Natural Products Help in the Control of Obesity? Current Insights and Future Perspectives
iawan Bonglee Kim Obesity is a global issue faced by many individuals worldwide. However, no drug has a pronounced effect with few side effects. Green tea, a well-known natural product, shows preventive effects against obesity by decreasing lipogenesis and increasing fat oxidation and antioxidant capacity. In contrast, other natural products are known to contribute to obesity. Relevant articles published on the therapeutic effect of natural products on obesity were retrieved from PubMed, Web of Science, and Scopus. The search was conducted by entering keywords such as “obesity”, &l...
Source: Molecules - September 13, 2023 Category: Chemistry Authors: Jiwon Park Fahrul Nurkolis Hyunji Won Jiye Yang Dayeon Oh Hyunkyung Jo Jinwon Choi Sanghyun Chung Rudy Kurniawan Bonglee Kim Tags: Review Source Type: research

Molecules, Vol. 28, Pages 6556: Ginsentide-like Coffeetides Isolated from Coffee Waste Are Cell-Penetrating and Metal-Binding Microproteins
ntony Kam Coffee processing generates a huge amount of waste that contains many natural products. Here, we report the discovery of a panel of novel cell-penetrating and metal ion-binding microproteins designated coffeetide cC1a–c and cL1–6 from the husk of two popular coffee plants, Coffea canephora and Coffea liberica, respectively. Combining sequence determination and a database search, we show that the prototypic coffeetide cC1a is a 37-residue, eight-cysteine microprotein with a hevein-like cysteine motif, but without a chitin-binding domain. NMR determination of cC1a reveals a compact s...
Source: Molecules - September 10, 2023 Category: Chemistry Authors: James P. Tam Jiayi Huang Shining Loo Yimeng Li Antony Kam Tags: Article Source Type: research

Molecules, Vol. 28, Pages 6547: Antioxidant and Antibacterial Activity of Mexican Oregano Essential Oil, Extracted from Plants Occurring Naturally in Semiarid Areas and Cultivated in the Field and Greenhouse in Northern Mexico
The objective was to compare the antioxidant and antibacterial activity of Mexican oregano essential oil obtained from plants occurring naturally in semiarid areas (Wild1 and Wild2), and those cultivated in the field (CField) and greenhouse (CGreenhouse) in northern Mexico. The Mexican oregano essential oil extraction was performed using the hydrodistillation method, the antioxidant activity was determined using the ABTS method, and the antibacterial activity was assessed through bioassays under the microwell method at nine different concentrations. The aim was to determine the diameter of the inhibition zone and, conseque...
Source: Molecules - September 9, 2023 Category: Chemistry Authors: Ruben I. Marin-Tinoco Angie Tatiana Ortega-Ram írez Maricela Esteban-Mendez Oscar Silva-Marrufo Laura E. Barragan-Ledesma Luis M. Valenzuela-N úñez Edwin A. Brice ño-Contreras Maria A. Sari ñana-Navarrete Abelardo Camacho-Luis Cayetano Navarrete-Moli Tags: Article Source Type: research

Molecules, Vol. 28, Pages 6424: Green Synthesis of Silver Nanoparticles Derived from Papaver rhoeas L. Leaf Extract: Cytotoxic and Antimicrobial Properties
Beylerli In the last few decades, the search for metal nanoparticles as an alternative to cancer treatments and antibiotics has increased. In this article, the spectroscopic (ultraviolet–visible (UV-vis), electron-dispersing X-ray (EDX), and Fourier transform infrared (FT-IR)), microscopic (field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), and atomic force microscope (AFM)), structural (X-ray diffractometer (XRD) and zetasizer), and analytic (thermogravimetric/differential thermal analyzer (TGA-DTA)) characterization of the silver nanoparticles (AgNPs) produced...
Source: Molecules - September 4, 2023 Category: Chemistry Authors: Polat İpek Re şit Yıldız Mehmet F ırat Baran Abdulkerim Hatipo ğlu Ay şe Baran Albert Sufianov Ozal Beylerli Tags: Article Source Type: research

Molecules, Vol. 28, Pages 6329: From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs
Maria Luisa Di Paolo Monoamine oxidases (MAOs) are well-known pharmacological targets in neurological and neurodegenerative diseases. However, recent studies have revealed a new role for MAOs in certain types of cancer such as glioblastoma and prostate cancer, in which they have been found overexpressed. This finding is opening new frontiers for MAO inhibitors as potential antiproliferative agents. In light of our previous studies demonstrating how a polyamine scaffold can act as MAO inhibitor, our aim was to search for novel analogs with greater inhibitory potency for human MAOs and possibly with antiproliferative ac...
Source: Molecules - August 29, 2023 Category: Chemistry Authors: Giulia Nordio Francesco Piazzola Giorgio Cozza Monica Rossetto Manuela Cervelli Anna Minarini Filippo Basagni Elisa Tassinari Lisa Dalla Via Andrea Milelli Maria Luisa Di Paolo Tags: Article Source Type: research

Molecules, Vol. 28, Pages 6213: Advances in Biodegradable Polymers and Biomaterials for Medical Applications & mdash;A Review
Molecules, Vol. 28, Pages 6213: Advances in Biodegradable Polymers and Biomaterials for Medical Applications—A Review Molecules doi: 10.3390/molecules28176213 Authors: Małgorzata Oleksy Klaudia Dynarowicz David Aebisher The introduction of new materials for the production of various types of constructs that can connect directly to tissues has enabled the development of such fields of science as medicine, tissue, and regenerative engineering. The implementation of these types of materials, called biomaterials, has contributed to a significant improvement in the quality of human life in terms of health...
Source: Molecules - August 24, 2023 Category: Chemistry Authors: Ma łgorzata Oleksy Klaudia Dynarowicz David Aebisher Tags: Review Source Type: research

Molecules, Vol. 28, Pages 6141: Hirsutine, an Emerging Natural Product with Promising Therapeutic Benefits: A Systematic Review
d Torequl Islam Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to treat various diseases and ailments. These food items are prominent sources of phytochemicals that exhibit chemopreventive and therapeutic effects against several diseases. Hirsutine (HSN) is a naturally occurring indole alkaloid found in various Uncaria species and has a multitude of therapeutic benefits. It is found in foodstuffs such as fish, seafood, meat, poultry, dairy, and some grain products among other things. In addition, it is present in fruits and vegetables including corn, cauliflower, mushrooms, po...
Source: Molecules - August 19, 2023 Category: Chemistry Authors: Md. Shimul Bhuia Polrat Wilairatana Jannatul Ferdous Raihan Chowdhury Mehedi Hasan Bappi Md Anisur Rahman Mohammad S. Mubarak Muhammad Torequl Islam Tags: Review Source Type: research

Molecules, Vol. 28, Pages 6132: Tolyporphins & ndash;Exotic Tetrapyrrole Pigments in a Cyanobacterium & mdash;A Review
Molecules, Vol. 28, Pages 6132: Tolyporphins–Exotic Tetrapyrrole Pigments in a Cyanobacterium—A Review Molecules doi: 10.3390/molecules28166132 Authors: Kathy-Uyen Nguyen Yunlong Zhang Qihui Liu Ran Zhang Xiaohe Jin Masahiko Taniguchi Eric S. Miller Jonathan S. Lindsey Tolyporphins were discovered some 30 years ago as part of a global search for antineoplastic compounds from cyanobacteria. To date, the culture HT-58-2, comprised of a cyanobacterium–microbial consortium, is the sole known producer of tolyporphins. Eighteen tolyporphins are now known—each ...
Source: Molecules - August 18, 2023 Category: Chemistry Authors: Kathy-Uyen Nguyen Yunlong Zhang Qihui Liu Ran Zhang Xiaohe Jin Masahiko Taniguchi Eric S. Miller Jonathan S. Lindsey Tags: Review Source Type: research

Molecules, Vol. 28, Pages 6095: Metal & ndash;Organic Frameworks as Formose Reaction Catalysts with Enhanced Selectivity
Molecules, Vol. 28, Pages 6095: Metal–Organic Frameworks as Formose Reaction Catalysts with Enhanced Selectivity Molecules doi: 10.3390/molecules28166095 Authors: Valentina Balloi Manuel Antonio Diaz-Perez Mayra Anabel Lara-Angulo David Villalgordo-Hernández Javier Narciso Enrique V. Ramos-Fernandez Juan Carlos Serrano-Ruiz The formose reaction is an autocatalytic series of aldol condensations that allows one to obtain monosaccharides from formaldehyde. The formose reaction suffers from a lack of selectivity, which hinders practical applications at the industrial level. Over the years, many a...
Source: Molecules - August 17, 2023 Category: Chemistry Authors: Valentina Balloi Manuel Antonio Diaz-Perez Mayra Anabel Lara-Angulo David Villalgordo-Hern ández Javier Narciso Enrique V. Ramos-Fernandez Juan Carlos Serrano-Ruiz Tags: Article Source Type: research

Molecules, Vol. 28, Pages 6040: A New Impregnated Adsorbent for Noble Metal Ion Sorption
jcik Noble metals (NM) such as gold, platinum, palladium, and rhodium are widely applied in the electronics and automotive industries. Thus, the search for cheap and selective sorbents for noble metals is economically justified. Nitrolite does not sorb noble metal ions. A new impregnated sorbent was prepared. The natural sorbent Nitrolite was impregnated with Aliquat 336 using a new warm impregnation method. After the impregnation process, Nitrolite adsorbed platinum(IV), palladium(II), and gold(III) ions from the chloride solutions. The values of the sorption capacity for palladium(II) and platinum(IV) ions were 47.63...
Source: Molecules - August 13, 2023 Category: Chemistry Authors: Zbigniew Hubicki Karolina Zinkowska Grzegorz W ójcik Tags: Article Source Type: research

Molecules, Vol. 28, Pages 6023: Deep Eutectic Solvents Formed by Glycerol and Xylitol, Fructose and Sorbitol: Effect of the Different Sugars in Their Physicochemical Properties
In this study, three deep eutectic solvents (DESs) formed by glycerol and xylitol, fructose and sorbitol and water in the molar ratio 1:2:3 were prepared and several physicochemical properties (refractive index, density, surface tension, viscosity, speed of sound, isobaric heat capacity and isentropic compressibility) were measured and analyzed in the 278.15–338.15 K temperature range. The results indicate a linear dependence with temperature for the following properties: surface tension, refractive index, density and isobaric molar heat capacity while viscosity values have been fitted to the Vogel&nd...
Source: Molecules - August 11, 2023 Category: Chemistry Authors: Laura Lomba Álvaro Werner Beatriz Giner Carlos Lafuente Tags: Article Source Type: research

Molecules, Vol. 28, Pages 5934: Caspase-1 Regulates the Apoptosis and Pyroptosis Induced by Phthalocyanine Zinc-Mediated Photodynamic Therapy in Breast Cancer MCF-7 Cells
o Chunhui Xia Photodynamic therapy (PDT) is an innovative and perspective antineoplastic therapy. Tetra-α-(4-carboxyphenoxy) phthalocyanine zinc (TαPcZn)-mediated PDT (TαPcZn-PDT) has shown antitumor activity in some tumor cells, but the manner in which caspase-1 is involved in the regulation of apoptosis and pyroptosis in the TαPcZn-PDT-treated breast cancer MCF-7 cells is unclear. Therefore, effects of TαPcZn-PDT on cytotoxicity, cell viability, apoptosis, pyroptosis, cellular reactive oxygen species (ROS), mitochondrial membrane potential (&...
Source: Molecules - August 8, 2023 Category: Chemistry Authors: Chunjie Ma Yu Wang Wei Chen Ting Hou Honglian Zhang Hongguang Zhang Xu Yao Chunhui Xia Tags: Article Source Type: research