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Total 1090 results found since Jan 2013.

Molecules, Vol. 27, Pages 6236: Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway
This study aimed to preliminarily explore the anti-inflammatory effect of ASD and the underlying mechanisms from the perspective of DNA methylation and inflammation-related pathways. We found that ASD significantly reduced the production of multiple inflammatory mediators, including nitric oxide (NO) and prostaglandin E2 (PGE2), in LPS-induced RAW264.7 cells. The expression of DNA methyltransferase (DNMT) 3b and inducible nitric oxide synthase (iNOS) was also obviously inhibited by the ASD treatment. The protein and mRNA levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were als...
Source: Molecules - September 22, 2022 Category: Chemistry Authors: Jin-Fang Luo Chon-Kit Lio Hua Zhou Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6251: Electric Cell-Substrate Impedance Sensing (ECIS) as a Convenient Tool to Assess the Potential of Low Molecular Fraction Derived from Medicinal Fungus Cerrena unicolor in Action on L929 and CT-26 Cell Lines
This study aimed to monitor the pharmacokinetics of different concentrations of substances isolated from the medicinal fungus Cerrena unicolor (ex-LMS) using the ECIS technique. In the study, mouse L929 fibroblasts and colon cancer CT26 cell lines were treated with different concentrations of the active fractions obtained from Cerrena unicolor: C1 = 2.285 (μg/mL); C2 = 22.85 (μg/mL); and C3 = 228.5 (μg/mL). This study demonstrated that the tested preparation from Cerrena unicolor had no considerable effect on the resistance, capacitance, and impedance of L929 fibroblast cells, which was an ...
Source: Molecules - September 22, 2022 Category: Chemistry Authors: Monika Prendecka-Wr óbel Dominika Pigo ń-Zając Magdalena Jaszek Anna Matuszewska Dawid Stefaniuk Grzegorz Opielak Katarzyna Piotrowska Mansur Rahnama-Hezavah Teresa Ma łecka-Massalska Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6178: Analysis of Protein-Protein Interactions for Intermolecular Bond Prediction
Y. Chen Protein-protein interactions often involve a complex system of intermolecular interactions between residues and atoms at the binding site. A comprehensive exploration of these interactions can help reveal key residues involved in protein-protein recognition that are not obvious using other protein analysis techniques. This paper presents and extends DiffBond, a novel method for identifying and classifying intermolecular bonds while applying standard definitions of bonds in chemical literature to explain protein interactions. DiffBond predicted intermolecular bonds from four protein complexes: Barnase-Barstar, R...
Source: Molecules - September 21, 2022 Category: Chemistry Authors: Justin Z. Tam Talulla Palumbo Julie M. Miwa Brian Y. Chen Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6150: Mycobacterium Time-Series Genome Analysis Identifies AAC2 & prime; as a Potential Drug Target with Naloxone Showing Potential Bait Drug Synergism
This study identifies naloxone as a potential drug candidate for a bait drug synergistic approach against Mycobacterium tuberculosis.
Source: Molecules - September 20, 2022 Category: Chemistry Authors: Vidya Niranjan Akshay Uttarkar Keerthana Murali Swarna Niranjan Jayalatha Gopal Jitendra Kumar Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6147: A Comprehensive Literature Review on Cardioprotective Effects of Bioactive Compounds Present in Fruits of Aristotelia chilensis Stuntz (Maqui)
er Fuentes Some fruits and vegetables, rich in bioactive compounds such as polyphenols, flavonoids, and anthocyanins, may inhibit platelet activation pathways and therefore reduce the risk of suffering from CVD when consumed regularly. Aristotelia chilensis Stuntz (Maqui) is a shrub or tree native to Chile with outstanding antioxidant activity, associated with its high content in anthocyanins, polyphenols, and flavonoids. Previous studies reveal different pharmacological properties for this berry, but its cardioprotective potential has been little studied. Despite having an abundant composition, and being rich in bi...
Source: Molecules - September 20, 2022 Category: Chemistry Authors: Rodr íguez Trostchansky Vogel Wood Palomo Wehinger Fuentes Tags: Review Source Type: research

Molecules, Vol. 27, Pages 6109: Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo3,4-dpyrimidine-amine Scaffold
ng Chen To search for Zika virus (ZIKV) antivirals, we have further explored previously reported 7H-pyrrolo[2,3-d]pyrimidines by examining an alternative substitution pattern of their central scaffold, leading to compound 5 with low micromolar antiviral activity. To circumvent the synthetic difficulties associated with compound 5, we have exploited a 1H-pyrazolo[3,4-d]pyrimidine scaffold and performed structure-activity relationship studies on its peripheral rings A and B. While ring B is less sensitive to structural modifications, an electron-withdrawing group at the para position of ring A is preferred for enhanced a...
Source: Molecules - September 19, 2022 Category: Chemistry Authors: Eunkyung Jung Ruben Soto-Acosta Robert J. Geraghty Liqiang Chen Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6071: Functionalized 10-Membered Aza- and Oxaenediynes through the Nicholas Reaction
rina A. Balova The scope and limitations of the Nicholas-type cyclization for the synthesis of 10-membered benzothiophene-fused heterocyclic enediynes with different functionalities were investigated. Although the Nicholas cyclization through oxygen could be carried out in the presence of an ester group, the final oxaenediyne was unstable under storage. Among the N-type Nicholas reactions, cyclization via an arenesulfonamide functional group followed by mild Co-deprotection was found to be the most promising, yielding 10-membered azaendiynes in high overall yields. By contrast, the Nicholas cyclization through the acyl...
Source: Molecules - September 17, 2022 Category: Chemistry Authors: Natalia A. Danilkina Ekaterina A. Khmelevskaya Anna G. Lyapunova Alexander S. D ’yachenko Alexander S. Bunev Rovshan E. Gasanov Maxim A. Gureev Irina A. Balova Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6032: Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug & mdash;A Review
Molecules, Vol. 27, Pages 6032: Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review Molecules doi: 10.3390/molecules27186032 Authors: Jun-O Jin Dhananjay Yadav Kajal Madhwani Nidhi Puranik Vishal Chavda Minseok Song Marine natural products are a discerning arena to search for the future generation of medications to treat a spectrum of ailments. Meanwhile, cancer is becoming more ubiquitous over the world, and the likelihood of dying from it is rising. Surgery, radiation, and chemotherapy are the mainstays of cancer treatment worldwide, but their extensive side ef...
Source: Molecules - September 16, 2022 Category: Chemistry Authors: Jun-O Jin Dhananjay Yadav Kajal Madhwani Nidhi Puranik Vishal Chavda Minseok Song Tags: Review Source Type: research

Molecules, Vol. 27, Pages 6052: Determination of Apoptotic Mechanism of Action of Tetrabromobisphenol A and Tetrabromobisphenol S in Human Peripheral Blood Mononuclear Cells: A Comparative Study
Conclusions: It was found that TBBPS, and more strongly TBBPA, triggered apoptosis in human PBMCs. Generally, the mitochondrial pathway was involved in the apoptotic action of tested compounds; nevertheless, TBBPS more strongly than TBBPA caused intrinsic pathway activation.
Source: Molecules - September 16, 2022 Category: Chemistry Authors: Anna Bara ńska Bo żena Bukowska Jaromir Micha łowicz Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6008: Brassica Genus Seeds: A Review on Phytochemical Screening and Pharmacological Properties
Bouajila Traditionally, Brassica species are widely used in traditional medicine, human food, and animal feed. Recently, special attention has been dedicated to Brassica seeds as source of health-promoting phytochemicals. This review provides a summary of recent research on the Brassica seed phytochemistry, bioactivity, dietary importance, and toxicity by screening the major online scientific database sources and papers published in recent decades by Elsevier, Springer, and John Wiley. The search was conducted covering the period from January 1964 to July 2022. Phytochemically, polyphenols, glucosinolates, and their de...
Source: Molecules - September 15, 2022 Category: Chemistry Authors: Ayadi Debouba Rahmani Bouajila Tags: Review Source Type: research

Molecules, Vol. 27, Pages 5959: Impact of Different Storage Regimes on the Levels of Physicochemical Characteristics, Especially Free Acidity in Talh (Acacia gerrardii Benth.) Honey
This study investigates how storage conditions (temperature and duration) may affect the physicochemical parameters, especially free acidity (FA), of Talh honey originating from Acacia gerrardii that have naturally high FA levels. Fresh Talh honey samples were kept at 0, 25, 35, and 45 °C, and analyzed monthly over a period of eight months. The Talh honey was monofloral with 69% A. gerrardii pollen content. The free acidity (FA) of freshly harvested Talh honey samples was higher (93 ± 0.3 meq/kg) than that of standard limits (≤50 meq/kg) and remained stable at 0 °C througho...
Source: Molecules - September 13, 2022 Category: Chemistry Authors: Hael S. A. Raweh Ahmed Yacine Badjah-Hadj-Ahmed Javaid Iqbal Abdulaziz S. Alqarni Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5841: A Carabrane-Type Sesquiterpenolide Carabrone from Carpesium cernuum Inhibits SW1990 Pancreatic Cancer Cells by Inducing Ferroptosis
n-Li Yang Pancreatic cancer has an extremely poor prognosis, and the clinical drugs for the treatment of pancreatic cancer are usually multi-drug combinations. Therefore, it is necessary to search for and find specific new bioactive agents against pancreatic cancer. Carabrone is a carabrane-type sesquiterpenolide extracted from Carpesium cernuum L., and this natural compound has been reported to be a potential anti-tumor agent. However, there are few reports on the function of carabrone related to anti-tumor activity in pancreatic cancer. Herein, cell experiments indicated that carabrone had anti-proliferation inhibiti...
Source: Molecules - September 9, 2022 Category: Chemistry Authors: Yi-Dan Zheng Ying Zhang Jun-Yi Ma Chun-Yan Sang Jun-Li Yang Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5809: An Investigation of the Anti-Depressive Properties of Phenylpropanoids and Flavonoids in Hemerocallis citrina Baroni
an Ying Jia The World Health Organization predicts that over the next several years, depression will become the most important mental health issue globally. Growing evidence shows that the flower buds of Hemerocallis citrina Baroni (H. citrina) possess antidepressant properties. In the search for new anti-depression drugs, a total of 15 phenylpropanoids and 22 flavonoids were isolated and identified based on spectral data (1D and 2D NMR, HR-ESI-MS, UV) from H. citrina. Among them, compound 8 was a novel compound, while compounds 1–4, 6, 9, 10, 15, 17, 24–26, 28, and 37 were isolated for th...
Source: Molecules - September 8, 2022 Category: Chemistry Authors: Tiancheng Ma Yu Sun Lida Wang Jinyu Wang Bo Wu Tingxu Yan Ying Jia Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5784: Terpenoids from the Seeds of Toona sinensis and Their Ability to Attenuate High Glucose-Induced Oxidative Stress and Inflammation in Rat Glomerular Mesangial Cells
g Wanzhong Li Toona sinensis (A. Juss.) Roem is an edible medicinal plant that belongs to the genus Toona within the Meliaceae family. It has been confirmed to display a wide variety of biological activities. During our continuous search for active constituents from the seeds of T. sinensis, two new acyclic diterpenoids (1–2), together with five known limonoid-type triterpenoids (3–7), five known apotirucallane-type triterpenoids (8–12), and three known cycloartane-type triterpenoids (13–15), were isolated and characterized. Their structures were identified base...
Source: Molecules - September 7, 2022 Category: Chemistry Authors: Ying Chen Hong Gao Xiaoxiao Liu Jinyi Zhou Yijin Jiang Feng Wang Rongshen Wang Wanzhong Li Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5787: Chemical Composition Assessment of Structural Parts (Seeds, Peel, Pulp) of Physalis alkekengi L. Fruits
Skrovankova Mlcek In recent years there has been an extensive search for nature-based products with functional potential. All structural parts of Physalis alkekengi (bladder cherry), including fruits, pulp, and less-explored parts, such as seeds and peel, can be considered sources of functional macro- and micronutrients, bioactive compounds, such as vitamins, minerals, polyphenols, and polyunsaturated fatty acids, and dietetic fiber. The chemical composition of all fruit structural parts (seeds, peel, and pulp) of two phenotypes of P. alkekengi were studied. The seeds were found to be a rich source of oil, yieldin...
Source: Molecules - September 7, 2022 Category: Chemistry Authors: Popova Petkova Mazova Ivanova Petkova Stoyanova Stoyanova Ercisli Okcu Skrovankova Mlcek Tags: Article Source Type: research