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Specialty: Biomedical Science
Therapy: Cancer Therapy
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Total 325 results found since Jan 2013.
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Integrative analysis identifies AKAP8L as an immunological and prognostic biomarker of pan-cancer
Aging (Albany NY). 2023 Sep 7;15. doi: 10.18632/aging.205003. Online ahead of print.ABSTRACTA-kinase anchoring protein 8L (AKAP8L) belong to the A-kinase anchoring protein (AKAP) family. Recent studies have proved that AKAP8L is associated with the progression of various tumors. To establish a more complete understanding of the significance of AKAP8L across various types of cancers, we conducted a detailed analysis of multiple histological datasets, including the level of gene expression in pancancer, biological function, molecular characteristics, as well as the diagnostic and prognostic value of AKAP8L in pancancer. Furt...
Source: Aging - September 8, 2023 Category: Biomedical Science Authors: Libo Zhou Jinhong Mei Runfu Cao Xiaoqiang Liu Bin Fu Ming Ma Binbin Gong Lianmin Luo Yifu Liu Qiqi Zhu Xuan Meng Source Type: research
The Eph/Ephrin system in primary bone tumor and bone cancer pain
This study mainly reviewed the roles of Eph/Ephrin system that has both tumor-suppressing and -promoting roles in primary bone tumors and bone cancer pain. Understanding the intracellular mechanisms of Eph/Ephrin system in tumorigenesis and metastasis of bone tumors might provide a foundation for the development of Eph/Ephrin targeted anti-cancer therapy.PMID:37413995 | DOI:10.18632/aging.204852
Source: Aging - July 6, 2023 Category: Biomedical Science Authors: Lujuan Wang Wei Li Yong Pan Source Type: research
Advances in cancer therapy: clinical benefit of new cancer drugs
Aging (Albany NY). 2023 Jun 19;undefined. doi: 10.18632/aging.204839. Online ahead of print.NO ABSTRACTPMID:37338507 | DOI:10.18632/aging.204839
Source: Aging - June 20, 2023 Category: Biomedical Science Authors: Daniel Tobias Michaeli Julia Caroline Michaeli Thomas Michaeli Source Type: research
Pan-cancer analysis identifies LPCATs family as a prognostic biomarker and validation of LPCAT4/WNT/ β-catenin/c-JUN/ACSL3 in hepatocellular carcinoma
Aging (Albany NY). 2023 May 23;15. doi: 10.18632/aging.204723. Online ahead of print.ABSTRACTLipid remodeling regulators are now being investigated as potential therapeutic targets for cancer therapy as a result of their involvement, which includes promoting cancer cells' adaptation to the restricted environment. Lysophosphatidylcholine acyltransferases (LPCATs, LPCAT1-4) are enzymes that regulate the remodeling of bio-membranes. The functions of these enzymes in cancer are largely unknown. In the current study, we found that genes belonging to the LPCAT family participated in tumor advancement and were strongly linked to ...
Source: Aging - June 9, 2023 Category: Biomedical Science Authors: Yaoyong Lu Hongfeng Liang Xiaoyin Li Haiwen Chen Changfu Yang Source Type: research
Co-delivery of EGCG and melittin with self-assembled fluoro-nanoparticles for enhanced cancer therapy
CONCLUSIONS: FEGCG@MPI NPs may offer a potential platform and promising strategy in cancer therapy.PMID:37277118 | DOI:10.18632/aging.204769
Source: Aging - June 5, 2023 Category: Biomedical Science Authors: Meiling Sun Yue Wu Zheyu Zhou Siyuan Liu Shuai Mao Guoqiang Li Source Type: research
m6A-mediated upregulation of lncRNA-AC026356.1 promotes cancer stem cell maintenance in lung adenocarcinoma via activating Wnt signaling pathway
Aging (Albany NY). 2023 May 3;15. doi: 10.18632/aging.204689. Online ahead of print.ABSTRACTLncRNA plays a pivotal role in the stemness and drug resistance of lung cancer. Here, we found that lncRNA-AC026356.1 was upregulated in stem spheres and chemo-resistant lung cancer cells. Our fish assay also shows that AC026356.1 was predominantly located in the cytoplasm of lung cancer cells and does not have protein-coding potential. Silencing AC026356.1 significantly inhibited proliferation and migration but increased apoptosis in A549-cisplatin (DDP) cells. Additionally, IGF2BP2 and the lncRNA-AC026356.1 positively regulated th...
Source: Aging - May 4, 2023 Category: Biomedical Science Authors: Zhen Zhang Xiaoning Tan Ruoxia Wu Tianhao Deng Huazhong Wang Xiulin Jiang Puhua Zeng Junqi Tang Source Type: research
Biological function analysis of ARHGAP39 as an independent prognostic biomarker in hepatocellular carcinoma
Aging (Albany NY). 2023 Apr 5;15. doi: 10.18632/aging.204635. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most common subtype of liver cancer, with a high morbidity and low survival rate. Rho GTPase activating protein 39 (ARHGAP39) is a crucial activating protein of Rho GTPases, a novel target in cancer therapy, and it was identified as a hub gene for gastric cancer. However, the expression and role of ARHGAP39 in hepatocellular carcinoma remain unclear. Accordingly, the cancer genome atlas (TCGA) data were used to analyze the expression and clinical value of ARHGAP39 in hepatocellular carcinoma. Fu...
Source: Aging - April 14, 2023 Category: Biomedical Science Authors: Yongqi Ding Yiyang Gong Hong Zeng Xuanrui Zhou Zichuan Yu Jingying Pan Minqin Zhou Shiwen Liu Wei Lai Source Type: research
