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Total 120 results found since Jan 2013.

Reply to: Myopathy in Myasthenia Positive for Antibodies Against MUSK, LRp4, and Titin.
Authors: Yamashita R, Okuno T, Mochizuki H PMID: 33281166 [PubMed - as supplied by publisher]
Source: Internal Medicine - December 9, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Myopathy or Myasthenia Positive for Antibodies Against MUSK, LRp4, and Titin.
Authors: Finsterer J, Frank M PMID: 33281162 [PubMed - as supplied by publisher]
Source: Internal Medicine - December 9, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Antimitochondrial Antibody-associated Myopathy with Slowly Progressive Cardiac Dysfunction: A Case Report.
Authors: Takahashi F, Sawada J, Minoshima A, Sakamoto N, Ono T, Akasaka K, Takei H, Nishino I, Hasebe N Abstract A 45-year-old woman was referred to our hospital for the evaluation of proximal muscle weakness and serum creatinine kinase elevation. She had atrial fibrillation and left ventricular asynergy. She was diagnosed with myopathy, accompanied by cardiomyopathy of unknown etiology. She was treated with prednisolone. After long-term follow-up and a detailed examination, the patient was diagnosed with antimitochondrial antibody (AMA)-associated myopathy with cardiac involvement. Although the patient received me...
Source: Internal Medicine - October 30, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

A MELAS Patient Developing Fatal Acute Renal Failure with Lactic Acidosis and Rhabdomyolysis.
Authors: Ito H, Fukutake S, Odake S, Okeda R, Tokunaga O, Kamei T Abstract We herein present a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), who developed serious acute renal failure with lactic acidosis, followed by rhabdomyolysis. Despite receiving intensive care, he suffered multiple cardiopulmonary arrests and died 10 days after presentation due to a sudden deterioration of his symptoms. Renal pathology revealed diffuse tubular necrosis with interstitial edema and tubular dilatation on light microscopy, and a severe degeneration of intracellular organell...
Source: Internal Medicine - July 11, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

C1-inhibitor Deficiency Induces Myositis-like Symptoms Via the Deposition of the Membrane Attack Complex in the Muscle.
Authors: Beck G, Yamashita R, Saeki C, Ogawa T, Shimizu M, Mochizuki H Abstract We herein report a 56-year-old Japanese woman who had been diagnosed with hereditary angioedema. She experienced progressing muscle weakness and pain in the upper and lower extremities. Blood tests revealed a marked increase in creatine kinase levels; however, myositis-specific autoantibodies were not detected. Serum C1-inhibitor activity and C4 levels were low. A muscle biopsy showed mild muscle fiber necrosis and C5b-9 deposition in the endomysial capillary vessel walls and sarcolemma, mimicking necrotizing myopathy. These results sug...
Source: Internal Medicine - May 30, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Dropped Head Syndrome Caused by Immune-mediated Necrotizing Myopathy.
Authors: Ueno T, Suzuki C, Nishino I, Tomiyama M PMID: 31327830 [PubMed - as supplied by publisher]
Source: Internal Medicine - July 24, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Anti-signal Recognition Particle Antibody-positive Necrotizing Myopathy with Secondary Cardiomyopathy: The First Myocardial Biopsy- and Multimodal Imaging-proven Case.
Authors: Takeguchi-Kikuchi S, Hayasaka T, Katayama T, Kano K, Takahashi K, Saito T, Sawada J, Minoshima A, Sakamoto N, Akasaka K, Miyokawa N, Nishino I, Ishibashi-Ueda H, Hasebe N Abstract A 69-year-old Japanese woman was admitted to our hospital with progressive muscle weakness and dysphagia. She was taking pitavastatin for dyslipidemia. Her serum creatine kinase was 6,300 U/L. Pitavastatin was stopped, but her symptoms deteriorated, and cardiac congestion appeared. A muscle biopsy showed necrotizing myopathy (NM), and anti-signal recognition particle (SRP) antibody was positive. 18F-fluorodeoxyglucose-positron em...
Source: Internal Medicine - July 13, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

An Anti-PM/Scl-75 Antibody-positive Japanese Woman who Developed Inflammatory Myopathy.
Authors: Nakamura Y, Miyanaga R, Shizukawa H, Shimohama S Abstract A 69-year-old Japanese woman presented with mild muscle weakness of the neck and symmetrical proximal parts of the upper and lower limbs. Laboratory tests, needle electromyography, and a muscle biopsy revealed inflammatory myopathy with an apparent clinical classification of polymyositis and positive findings for anti-PM/Scl-75 antibody. This antibody is rare among Japanese populations, and most Japanese patients with the antibody are not classified with the inflammatory myopathy seen in polymyositis. The muscle biopsy also showed marked necrotic an...
Source: Internal Medicine - June 11, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Respiratory Failure Due to Diaphragm Sarcoidosis Diagnosed by a Computed Tomography-guided Needle Biopsy.
Authors: Fujioka Y, Oda N, Mitani R, Hyodo T, Takata I Abstract Sarcoidosis is a multisystem noncaseating granulomatous disorder of unknown etiology that can be found in almost any organ, but symptomatic respiratory muscle involvement is rare. We herein report the case of a 77-year-old woman with diaphragm sarcoidosis diagnosed by a computed tomography (CT)-guided needle biopsy that was successfully treated with a corticosteroid. The patient presented with dyspnea that lasted for two weeks and respiratory failure. CT revealed diffuse diaphragm thickening with contrast enhancement, which might be a characteristic im...
Source: Internal Medicine - February 26, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Dropped Head in Sporadic Late-onset Nemaline Myopathy.
Authors: Nakamura K, Shibuya K, Nishino I, Kuwabara S PMID: 30799359 [PubMed - as supplied by publisher]
Source: Internal Medicine - February 26, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Pembrolizumab-induced Ocular Myasthenia Gravis with Anti-titin Antibody and Necrotizing Myopathy.
Authors: Onda A, Miyagawa S, Takahashi N, Gochi M, Takagi M, Nishino I, Suzuki S, Oishi C, Yaguchi H Abstract A 73-year-old man developed diplopia after the administration of pembrolizumab for lung adenocarcinoma. He had ptosis and external ophthalmoplegia without general muscle weakness. Serum CK levels were elevated. Although autoantibodies to acetylcholine receptor and muscle-specific kinase, the edrophonium test, and the repetitive nerve stimulation test were all negative, anti-titin autoantibody was positive, leading to the diagnosis of myasthenia gravis (MG). Muscle pathology showed necrotizing myopathy with ...
Source: Internal Medicine - February 6, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Falling after Starting Running in a Case of Myoclonus Epilepsy Associated with Ragged-red Fibers with a 8344A > G mtDNA Mutation.
Falling after Starting Running in a Case of Myoclonus Epilepsy Associated with Ragged-red Fibers with a 8344A>G mtDNA Mutation. Intern Med. 2018 Jul 06;: Authors: Miyaue N, Yamanishi Y, Tada S, Ando R, Nagai M, Nomoto M Abstract Myoclonus epilepsy associated with ragged-red fibers (MERRF) is traditionally characterized by myoclonus, generalized epilepsy and ragged-red fibers. We herein report a 42-year-old man who complained of falling after starting running, symptoms resembling those of paroxysmal kinesigenic dyskinesia. He showed only slight muscle weakness of the right quadriceps femoris. Muscle ...
Source: Internal Medicine - July 10, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody.
Authors: Kusumoto T, Okamori S, Masuzawa K, Asakura T, Nishina N, Chubachi S, Naoki K, Fukunaga K, Betsuyaku T Abstract A 72-year-old man was admitted due to dyspnea on exertion with interstitial shadows and elevated serum creatinine kinase (CK). Despite a close examination, which included magnetic resonance imaging (MRI), we could not diagnose myopathy. Prednisolone was administered and gradually tapered. One year later, anti-signal recognition particle (SRP) antibody was confirmed and he was re-admitted for hypoxemia with elevated CK. MRI revealed muscle edema and a histopathological examination of a muscle biops...
Source: Internal Medicine - March 3, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Anti-mitochondrial M2 Antibodies and Myopathy.
Authors: Finsterer J, Zarrouk-Mahjoub S PMID: 29279518 [PubMed - as supplied by publisher]
Source: Internal Medicine - December 28, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Anti-mitochondrial M2 Antibodies and Myopathy: Author's Reply.
Authors: Konishi H, Fukuzawa K, Mori S, Satomi-Kobayashi S, Kiuchi K, Suzuki A, Akita T, Yano Y, Yoshida A, Hirata KI PMID: 29279475 [PubMed - as supplied by publisher]
Source: Internal Medicine - December 28, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research