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Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

New drugs: Exenatide – an injectable diabetic agent and Denosumab – a monoclonal antibody for postmenopausal osteoporosis
Exanatide (Byetta): the first injectable synthetic analogue of the incretin hormone glucagon-like peptide-1 (GLP-1) note that the glyptins inhibit incretin breakdown and are thus incretin “enhancers” not “mimics” PBS approved for type 2 diabetics as an addition to the combination of metformin and  sulphonylurea to help lower HbA1c below 7% or as dual Rx for those who cannot tolerate metformin or a sulphonylurea. dose: is given bd s/c within 1 hour BEFORE meals starting at 5 mcg per dose which should be at least 6 hours apart after 1 month, dose can be increased to 10mcg bd main adverse effect...
Source: Oz E Medicine - emergency medicine in Australia - December 11, 2010 Category: Emergency Medicine Authors: Gary Tags: new drugs Source Type: blogs