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Fight Aging! Newsletter, June 21st 2021
This study showed that the leakage of this mitochondrial nucleic material may occur as a result of mitochondrial dysfunction, which may involve genetic mutations in genes encoding mitochondrial proteins or incomplete degradation of mitochondrial dsDNA in the lysosome - which is a 'degradation factory' of the cell. Upon the leakage into the cytoplasm, this undegraded dsDNA is detected by a 'foreign' DNA sensor of the cytoplasm (IFI16) which then triggers the upregulation of mRNAs encoding for inflammatory proteins." Using a PD zebrafish model (gba mutant), the researchers demonstrated that a combination of PD-like ph...
Source: Fight Aging! - June 20, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Mastering Intensive Care 032 with Kate Harding
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Kate Harding – Losing Richard: What can we learn from her intensivist husband’s shocking death? What is it like to witness an intensivist struggle? And what can we learn from the shocking death of an intensivist? This special Mastering Intensive Care episode is on a difficult and important topic. Rather than focusing on bringing our best selves to work, the focus of this episode is the ultimate tragedy of our profession, doctor suicide. I warn you that this is a sa...
Source: Life in the Fast Lane - June 27, 2018 Category: Emergency Medicine Authors: Andrew Davies Tags: Mastering Intensive Care Andrew Davies doctor intensivist Kate Harding Mental Health Richard Harding suicide Source Type: blogs