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Iridium(III) complex induces apoptosis in HeLa cells by regulating mitochondrial and PI3K/AKT signaling pathways: In vitro and in vivo experiments
Bioorg Chem. 2023 Sep 16;141:106867. doi: 10.1016/j.bioorg.2023.106867. Online ahead of print.ABSTRACTCyclometalated iridium complexes with mitochondrial targeting show great potential as substitutes for platinum-based complexes because of their strong anti-cancer properties. Three novel cyclometalated iridium(III) compounds were synthesized and evaluated in five different cell lines as part of the ongoing systematic investigations of these compounds. The complexes were prepared using 4,7-dichloro-1,10-phenanthroline ligands. The cytotoxicity of complexes Ir1-Ir3 towards HeLa cells was shown to be high, with IC50 values of...
Source: Bioorganic Chemistry - September 21, 2023 Category: Chemistry Authors: Shu-Fen He Wei-Chao Han Ying-Ying Shao Han-Bin Zhang Wen-Xin Hong Qiu-Hong Yang Yu-Qing Zhang Rui-Rong He Jing Sun Source Type: research
The active phthalate metabolite, DHEP, induces proliferation and metastasis of prostate cancer cells via upregulation of β-catenin and downregulation of KLF7
Bioorg Chem. 2023 Sep 15;141:106864. doi: 10.1016/j.bioorg.2023.106864. Online ahead of print.ABSTRACTPhthalates such as DHEP are among the widely used compounds in industry. It has been shown that DHEP can convey various biological consequences in mammalian cells, among them, the carcinogenic effects of DHEP are emphasized. The present study aimed to assess the impact of DHEP exposure on the proliferation and invasiveness of DU145 prostate cancer cells through in vitro and in vivo models. The DU145 cells were treated with increasing concentrations of DHEP and the tumorigenic parameters were analyzed. KLF7 as a probable me...
Source: Bioorganic Chemistry - September 21, 2023 Category: Chemistry Authors: Hecheng Li Jianping Li Yubo Ma Ziming Wang Zihe Peng Hang Xu Hang Bi Shaik Althaf Hussain Zhaolun Li Source Type: research
Derivative of cinnamic acid inhibits T3SS of Xanthomonas oryzae pv. oryzae through the HrpG-HrpX regulatory cascade
Bioorg Chem. 2023 Sep 18;141:106871. doi: 10.1016/j.bioorg.2023.106871. Online ahead of print.ABSTRACTBacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) has a significant impact on rice yield and quality worldwide. Traditionally, bactericide application has been commonly used to control this devastating disease. However, the overuse of fungicides has led to a number of problems such as the development of resistance and environmental pollution. Therefore, the development of new methods and approaches for disease control are still urgent. In this paper, a series of cinnamic acid derivatives were design...
Source: Bioorganic Chemistry - September 21, 2023 Category: Chemistry Authors: Yu Shi Lan-Tu Xiong Hui Li Wen-Long Li Dylan O'Neill Rothenberg Li-Sheng Liao Xin Deng Gao-Peng Song Zi-Ning Cui Source Type: research
Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells
Bioorg Chem. 2023 Sep 18;141:106873. doi: 10.1016/j.bioorg.2023.106873. Online ahead of print.ABSTRACTMetastasis is the leading cause of cancer-related mortality, targeting angiogenesis emerges as a therapeutic strategy for the treatment of melanoma metastasis. Discovery of new antiangiogenic compounds with specific mechanism of action is still desired. In present study, a bioassay-guidance uncovers the EtOAc extract of a marine-derived fungus Aspergillus clavutus LZD32-24 with significant inhibitory activity against the angiogenesis in Tg (fli1a: EGFP) zebrafish model. Extensive chromatographic fractionation led to the is...
Source: Bioorganic Chemistry - September 21, 2023 Category: Chemistry Authors: Xingchen Guo Aili Fan Xinyi Qi Dong Liu Jian Huang Wenhan Lin Source Type: research
Singlet oxygen in the removal of organic pollutants: An updated review on the degradation pathways based on mass spectrometry and DFT calculations
Chemosphere. 2023 Sep 19:140203. doi: 10.1016/j.chemosphere.2023.140203. Online ahead of print.ABSTRACTThe degradation of pollutants by a non-radical pathway involving singlet oxygen (1O2) is highly relevant in advanced oxidation processes. Photosensitizers, modified photocatalysts, and activated persulfates can generate highly selective 1O2 in the medium. The selective reaction of 1O2 with organic pollutants results in the evolution of different intermediate products. While these products can be identified using mass spectrometry (MS) techniques, predicting a proper degradation mechanism in a 1O2-based process is still ch...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Manoj P Rayaroth Usha K Aravind Grzegorz Boczkaj Charuvila T Aravindakumar Source Type: research
Toxicity of bisphenol A (BPA) and its analogues BPF and BPS on the free-floating macrophyte Salvinia biloba
Chemosphere. 2023 Sep 19:140235. doi: 10.1016/j.chemosphere.2023.140235. Online ahead of print.ABSTRACTEvidence linking the toxicity of bisphenol A (BPA) to environmental and public-health issues has led to restrictions on its use. This compound has been gradually replaced with analogues proposed as a safer alternative, normally bisphenol F (BPF) and bisphenol S (BPS), but these substitutes are structurally almost identical to BPA, suggesting they may pose similar risks. The effects of BPA and these analogues were compared for antioxidant activity, lipid peroxidation, free-radical generation, photosynthetic pigments, and c...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Jaqueline da Silva Santos Montcharles da Silva Pontes Matheus Bispo de Souza Simone Yasuda Fernandes Ricardo Antunes de Azevedo Gilberto Jos é de Arruda Etenaldo Felipe Santiago Source Type: research
Applied potential assisted biodegradation of amoxicillin (AMX) using bacterial consortium isolated from a waste dump site
This study aims to explore the potential of using a bio-electrochemical system (BES) to remove Amoxicillin (AMX) from artificially contaminated soil using a microbial consortium and pure culture isolates. Under desired conditions, including an initial AMX concentration of 150 mg/L, 5 mg/L tryptone as the nitrogen source, pH of 7, temperature of 29 °C, an applied potential of 0.8 V, and an inoculum dose of 1% w/v, the BES showed a maximum degradation of 97.9% of AMX with the microbial consortium (HP03, HP09, and HP10). High performance liquid chromatography-mass spectrometry was used to analyse the intermediates formed dur...
Source: Chemosphere - September 21, 2023 Category: Chemistry Authors: Pavithra Muthukumar Sathya Harshavardhan Mohan Jung-Hee Park Kamala-Kannan Seralathan Byung-Taek Oh Source Type: research
A CRISPR-Cas12a-based platform facilitates the detection and serotyping of Streptococcus suis serotype 2
In this study, we developed a high-fidelity detection and serotyping platform for S. suis serotype 2 based on recombinase polymerase amplification (RPA) and a clustered regularly interspaced short palindromic repeat (CRISPR)-Cas12a system called Cards-SSJ/K. Cards-SSJ had a detection limit of 10 CFU, takes <60 min, and no cross-reaction was found with other S. suis serotypes, closely related Streptococcus spp., or common pig pathogens, and Cards-SSK could differentiate serotype 2 from serotype 1/2. Results from Cards-SSJ and qPCR were equivalent in detecting S. suis serotype 2 in tissue samples. Analysis indicated that ...
Source: Talanta - September 21, 2023 Category: Chemistry Authors: Lu Wang Jing Sun Jiyu Zhao Jieyu Bai Yueling Zhang Yao Zhu Wanjiang Zhang Chunlai Wang Paul R Langford Siguo Liu Gang Li Source Type: research
Amorphous amEu-NH < sub > 2 < /sub > BDC and amTb-NH < sub > 2 < /sub > BDC as ratio fluorescence probes for smartphone-integrated naked eye detection of bacillus anthracis biomarker
Talanta. 2023 Sep 14;267:125164. doi: 10.1016/j.talanta.2023.125164. Online ahead of print.ABSTRACTThe abnormal concentration of anthrax spore biomarker 2,6-pyridinedicarboxylic acid (2,6-DPA) will seriously affect public health. Therefore, a sensitive and rapid assay for 2,6-DPA monitoring is of vital importance. In this work, novel nano-sized amorphous Eu-NH2BDC (amEu-NH2BDC) and amorphous Tb-NH2BDC (amTb-NH2BDC) metal organic frameworks are prepared by adjusting the ratio of metal and ligand, respectively. Both of them exhibit highly sensitive and selective ratiometric fluorescence detection for 2,6-DPA with wider linea...
Source: Talanta - September 21, 2023 Category: Chemistry Authors: Jiaqi Dang Min Li Wenhui Fang Ying Wu Shixian Xin Yutao Cao Hong Zhao Source Type: research
The performance of hypochlorous acid modified Ag nanoparticle-based assay in the determination of total antioxidant capacity of Boswellia Serrata and Aronia
In this study, the SNPAC method was developed by using hypochlorous (ClO-) at pH 9.3. Polyvinylpyrrolidone (PVP) was used as a stabilizer. The existence of HOCl enables to formation stronger and more stable yellow emission which gives sensitivity. As a result, lower LOD and LOQ values were achieved by the AgNP-HOCl method. The obtaining lower values was attributed to the reoxidation of silver atoms with ClO- ions in the presence of PVP. The newly modified method was applied to the total antioxidant capacity (TAC) measurement of Boswellia Serrata, Aronia Melanocarpa tea, and juice. The results were compared with the results...
Source: Talanta - September 21, 2023 Category: Chemistry Authors: Z ülal Eryaman Julide Hizal Mesut Y ılmazoğlu U ğur Daban Hande Mert Nergiz Kanmaz Source Type: research
Liquid chromatographic retention time prediction models to secure and improve the feature annotation process in high-resolution mass spectrometry
Talanta. 2023 Sep 17;267:125214. doi: 10.1016/j.talanta.2023.125214. Online ahead of print.ABSTRACTThe development of quantitative structure-retention relationship (QSRR) models has, until recently, required an adequate selection of molecular descriptors necessarily obtained based on a known chemical structure. However, these complex descriptors are not always available nor calculable when the high-resolution mass spectrometry (HRMS) annotation process is underway. Depending on the level of annotation, many structures or even various molecular formulas could be candidates. To secure and improve the annotation process and t...
Source: Talanta - September 21, 2023 Category: Chemistry Authors: Julien Parinet Yassine Makni Thierno Diallo Thierry Gu érin Source Type: research
A plasmonic gold nano-surface functionalized with the estrogen receptor for fast and highly sensitive detection of nanoplastics
Talanta. 2023 Sep 16;267:125211. doi: 10.1016/j.talanta.2023.125211. Online ahead of print.ABSTRACTNanoplastics are a global emerging environmental problem whose effects might pose potential threats to the human's health. Despite the relevance of the issue, fast, reliable and quantitative in situ analytical approaches to determine nanoplastics are not yet available. The aim of this work was to devise an optical sensor with the goal of direct detecting and quantifying nanoplastics in seawater without sample pre-treatments. To this purpose, a nano-plasmonic biosensor was developed by exploiting an Estrogen Receptor (ER) reco...
Source: Talanta - September 21, 2023 Category: Chemistry Authors: Mimimorena Seggio Francesco Arcadio Nunzio Cennamo Luigi Zeni Alessandra Maria Bossi Source Type: research
Polyazine nanoparticles as anchors of PQQ glucose dehydrogenase for its most efficient bioelectrocatalysis
We report on the drop-cast production of glucose biosensors based on the most efficient bioelectrocatalysis by pyrroloquinoline quinone dependent glucose dehydrogenase (PQQ GDH). To orient the enzyme upon immobilization we suggest using poly(Methylene Green) (p(MG)) nanoparticles acting as anchors. Synthesis of polymeric anchors has been carried out in course of Methylene Green electropolymerization, which allowed to tune polymer-to-monomer ratio in the drop-cast mixtures varying the monomer concentration and applying different number of potential sweep cycles. Except for elimination of electrochemical step for the electro...
Source: Talanta - September 21, 2023 Category: Chemistry Authors: Maria A Komkova Anna S Alexandrovich Arkady A Karyakin Source Type: research
Ag-Doped Free-Standing 2D TiO2 Sheets: Electronic, Optical, Magnetic, and Self-Healing Behaviour
Chemphyschem. 2023 Sep 21:e202300447. doi: 10.1002/cphc.202300447. Online ahead of print.ABSTRACTBeyond a critical doping level, Ag - 2D TiO2 sheets (ATO) are deemed to be a flexible transparent conductor, useful for visible-range functional photonic/optoelectronic devices/sensors, sunlight-sensitive catalysis, and light-activated resistive switching. Due to the lack of control of surface energy which often leads to the formation of structural defects and even dimensionality crossover (2D to 0D) of materials during doping reaction, it is challenging to obtain ATO with a controlled doping level. Gauging the urgency, therefo...
Source: Chemphyschem - September 21, 2023 Category: Chemistry Authors: Itishree Pradhan Anwesha Mahapatra Arkamita Bandyopadhyay Alpana Nayak Prashant Kumar Source Type: research
Relationship Between Stress Modulated Metallicity and Plasmon in Graphene Nanoribbons
This study provides a theoretical basis for the application of graphene nanoribbons in the field of optoelectronics under strain-engineering conditions.PMID:37731169 | DOI:10.1002/cphc.202300348
Source: Chemphyschem - September 21, 2023 Category: Chemistry Authors: Na Zhang Zhiyuan Yang Zhongyuan Zhang Jingang Wang Source Type: research
