Iron Overload –Dependent Ferroptosis Aggravates LPS-Induced Acute Lung Injury by Impairing Mitochondrial Function
In conclusion, ferroptosis contributes to the pathogenesis of ALI and aggravates ALI by impairing mitochondrial function. (Source: Inflammation)
Source: Inflammation - May 9, 2024 Category: Allergy & Immunology Source Type: research
Gypenoside XLIX Activates the Sirt1/Nrf2 Signaling Pathway to Inhibit NLRP3 Inflammasome Activation to Alleviate Septic Acute Lung Injury
This study induced ALI in mice through cecal ligation and puncture surgery and investigated the biological activity and potential mechanisms of Gypenoside XLIX (40 mg/kg) by intraperitoneal injection. Thein vitro ALI model was established using mouse lung epithelial (MLE-12) cells stimulated with lipopolysaccharide (LPS) and adenosine triphosphate (ATP). Various methods, including Hematoxylin and Eosin (H&E) staining, biochemical assay kits, Quantitative Polymerase Chain Reaction (qPCR) analysis, Western blotting, Terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL) assay, immunofluorescence, and flow...
Source: Inflammation - May 8, 2024 Category: Allergy & Immunology Source Type: research
Dual Regulation of Nicotine on NLRP3 Inflammasome in Macrophages with the Involvement of Lysosomal Destabilization, ROS and α7nAChR
AbstractNicotine, the primary alkaloid in tobacco products, has been shown to have immunoregulatory function in at least 20 diseases. The biological mechanism of action of nicotine immunoregulation is complex, resulting in an improvement of some disease states and exacerbation of others. Given the central role of the NLRP3 inflammasome in macrophages among multiple inflammatory diseases, this study examined how nicotine alters NLRP3 inflammasome activation in macrophages. NLRP3 inflammasome activation was examined mechanistically in the context of different nicotine dosages. We show NLRP3 inflammasome activation, apoptosis...
Source: Inflammation - May 8, 2024 Category: Allergy & Immunology Source Type: research
Gypenoside XLIX Activates the Sirt1/Nrf2 Signaling Pathway to Inhibit NLRP3 Inflammasome Activation to Alleviate Septic Acute Lung Injury
This study induced ALI in mice through cecal ligation and puncture surgery and investigated the biological activity and potential mechanisms of Gypenoside XLIX (40 mg/kg) by intraperitoneal injection. Thein vitro ALI model was established using mouse lung epithelial (MLE-12) cells stimulated with lipopolysaccharide (LPS) and adenosine triphosphate (ATP). Various methods, including Hematoxylin and Eosin (H&E) staining, biochemical assay kits, Quantitative Polymerase Chain Reaction (qPCR) analysis, Western blotting, Terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL) assay, immunofluorescence, and flow...
Source: Inflammation - May 8, 2024 Category: Allergy & Immunology Source Type: research
Dual Regulation of Nicotine on NLRP3 Inflammasome in Macrophages with the Involvement of Lysosomal Destabilization, ROS and α7nAChR
AbstractNicotine, the primary alkaloid in tobacco products, has been shown to have immunoregulatory function in at least 20 diseases. The biological mechanism of action of nicotine immunoregulation is complex, resulting in an improvement of some disease states and exacerbation of others. Given the central role of the NLRP3 inflammasome in macrophages among multiple inflammatory diseases, this study examined how nicotine alters NLRP3 inflammasome activation in macrophages. NLRP3 inflammasome activation was examined mechanistically in the context of different nicotine dosages. We show NLRP3 inflammasome activation, apoptosis...
Source: Inflammation - May 8, 2024 Category: Allergy & Immunology Source Type: research
Esaxerenone Inhibits Interferon- γ Induced Pyroptosis of Macrophages in the Lungs of Aldosterone-treated Mice
In conclusion, the inhibition of macrophage pyroptosis can effectively alleviate lung injury. (Source: Inflammation)
Source: Inflammation - May 7, 2024 Category: Allergy & Immunology Source Type: research
Targeted Demethylation of FOXP3-TSDR Enhances the Suppressive Capacity of STAT6-deficient Inducible T Regulatory Cells
In conclusion, the deactivation of STAT6 and TSDR-targeted demethylation via CRISPR-T ET1 is sufficient to induce iTregs with heightened stability and increased suppressive capacity, offering potential applications against inflammatory and autoimmune diseases. (Source: Inflammation)
Source: Inflammation - May 3, 2024 Category: Allergy & Immunology Source Type: research
TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2
AbstractPeriodontitis, characterized by progressive alveolar bone destruction, leads to the loss of attachment and stability of the affected teeth. Macrophages, especially the proinflammatory M1 subtype, are key in periodontitis pathogenesis, driving the disease's inflammatory and destructive processes. Despite existing insight into their involvement, comprehensive understanding of the underlying molecular mechanisms remains limited. TRPV1 is a non-selective cation channel protein and is known to regulate cellular function and homeostasis in macrophages. Our research objective was to investigate the impact of TRPV1 on the ...
Source: Inflammation - May 3, 2024 Category: Allergy & Immunology Source Type: research
Targeted Demethylation of FOXP3-TSDR Enhances the Suppressive Capacity of STAT6-deficient Inducible T Regulatory Cells
In conclusion, the deactivation of STAT6 and TSDR-targeted demethylation via CRISPR-T ET1 is sufficient to induce iTregs with heightened stability and increased suppressive capacity, offering potential applications against inflammatory and autoimmune diseases. (Source: Inflammation)
Source: Inflammation - May 3, 2024 Category: Allergy & Immunology Source Type: research
TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2
AbstractPeriodontitis, characterized by progressive alveolar bone destruction, leads to the loss of attachment and stability of the affected teeth. Macrophages, especially the proinflammatory M1 subtype, are key in periodontitis pathogenesis, driving the disease's inflammatory and destructive processes. Despite existing insight into their involvement, comprehensive understanding of the underlying molecular mechanisms remains limited. TRPV1 is a non-selective cation channel protein and is known to regulate cellular function and homeostasis in macrophages. Our research objective was to investigate the impact of TRPV1 on the ...
Source: Inflammation - May 3, 2024 Category: Allergy & Immunology Source Type: research
The Role of Macrophage Death in Periodontitis: A Review
This article reviews the typical mechanisms underlying macrophage death and its effects on periodontitis. We describe five forms of macrophage death in periodontitis: apoptosis, pyroptosis, necroptosis, ferroptosis, and ETosis. Our review of macrophage death in the pathophysiology of periodontitis enhances comprehension of the pathogenesis of periodontitis that will be useful for clinical practice. Although our review elucidates the complex mechanisms by which macrophage death and inflammatory pathways perpetuate periodontitis, unresolved issues remain, necessitating further research. (Source: Inflammation)
Source: Inflammation - May 1, 2024 Category: Allergy & Immunology Source Type: research
Retraction Note: Geniposide Attenuates LPS-Induced Injury via Up-Regulation of miR-145 in H9c2 Cells
(Source: Inflammation)
Source: Inflammation - May 1, 2024 Category: Allergy & Immunology Source Type: research
The Role of Macrophage Death in Periodontitis: A Review
This article reviews the typical mechanisms underlying macrophage death and its effects on periodontitis. We describe five forms of macrophage death in periodontitis: apoptosis, pyroptosis, necroptosis, ferroptosis, and ETosis. Our review of macrophage death in the pathophysiology of periodontitis enhances comprehension of the pathogenesis of periodontitis that will be useful for clinical practice. Although our review elucidates the complex mechanisms by which macrophage death and inflammatory pathways perpetuate periodontitis, unresolved issues remain, necessitating further research. (Source: Inflammation)
Source: Inflammation - May 1, 2024 Category: Allergy & Immunology Source Type: research
Retraction Note: Geniposide Attenuates LPS-Induced Injury via Up-Regulation of miR-145 in H9c2 Cells
(Source: Inflammation)
Source: Inflammation - May 1, 2024 Category: Allergy & Immunology Source Type: research
