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Total 992 results found since Jan 2013.

Molecules, Vol. 28, Pages 5867: Suppression of Inflamm-Aging by Moringa oleifera and Zingiber officinale Roscoe in the Prevention of Degenerative Diseases: A Review of Current Evidence
pol Inflammation or inflamm-aging is a chronic low-grade inflammation that contributes to numerous types of degenerative diseases among the elderly and might be impeded by introducing an anti-inflammatory agent like Moringa oleifera Lam (moringa) and Zingiber officinale Roscoe (ginger). Therefore, this paper aims to review the role of moringa and ginger in suppressing inflamm-aging to prevent degenerative diseases. Various peer-reviewed publications were searched and downloaded using the reputed search engine “Pubmed” and “Google Scholar”. These materials were rev...
Source: Molecules - August 3, 2023 Category: Chemistry Authors: Nur Fatin Nabilah Mohd Sahardi Suzana Makpol Tags: Review Source Type: research

Molecules, Vol. 28, Pages 5824: Neurological Applications of Celery (Apium graveolens): A Scoping Review
In conclusion, the safety of A. graveolens extract and NBP can be further investigated clinically on different neurological disorders based on their potential role in different targeted pathways.
Source: Molecules - August 2, 2023 Category: Chemistry Authors: Terence Yew Chin Tan Xin Yi Lim Nor Azrina Norahmad Hemahwathy Chanthira Kumar Bee Ping Teh Nai Ming Lai Ami Fazlin Syed Mohamed Tags: Review Source Type: research

Molecules, Vol. 28, Pages 5766: Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain
ika Neuropathic pain is a debilitating condition that affects millions of people worldwide. Numerous studies indicate that this type of pain is a chronic condition with a complex mechanism that tends to worsen over time, leading to a significant deterioration in patients’ quality of life and issues like depression, disability, and disturbed sleep. Presently used analgesics are not effective enough in neuropathy treatment and may cause many side effects due to the high doses needed. In recent years, many researchers have pointed to the important role of chemokines not only in the development and maintenanc...
Source: Molecules - July 30, 2023 Category: Chemistry Authors: Katarzyna Pawlik Joanna Mika Tags: Review Source Type: research

Molecules, Vol. 28, Pages 5728: Discrimination of Milk Freshness Based on Synchronous Two-Dimensional Visible/Near-Infrared Correlation Spectroscopy Coupled with Chemometrics
heng Jun Li Milk is one of the preferred beverages in modern healthy diets, and its freshness is of great significance for product sales and applications. By combining the two-dimensional (2D) correlation spectroscopy technique and chemometrics, a new method based on visible/near-infrared (Vis/NIR) spectroscopy was proposed to discriminate the freshness of milk. To clarify the relationship be-tween the freshness of milk and the spectra, the changes in the physicochemical indicators of milk during storage were analyzed as well as the Vis/NIR spectra and the 2D-Vis/NIR correlation spectra. The threshold-value method, l...
Source: Molecules - July 28, 2023 Category: Chemistry Authors: Dan Peng Rui Xu Qi Zhou Jinxia Yue Min Su Shaoshuai Zheng Jun Li Tags: Article Source Type: research

Molecules, Vol. 28, Pages 5717: The Garlic Tree of Borneo, Scorodocarpus borneensis (Baill.) Becc. (Olacaceae): Potential Utilization in Pharmaceutical, Nutraceutical, and Functional Cosmetic Industries
Mazdida Sulaiman Scorodocarpus borneensis (Baill.) Becc. is attracting increased attention as a potential commercial medicinal plant product in Southeast Asia. This review summarizes the current knowledge on the taxonomy, habitat, distribution, medicinal uses, natural products, pharmacology, toxicology, and potential utilization of S. borneesis in the pharmaceutical/nutraceutical/functional cosmetic industries. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1866 to 2022. A total of 33 natural products have been identif...
Source: Molecules - July 28, 2023 Category: Chemistry Authors: Christophe Wiart Afsana Amin Shorna Mohammed Rahmatullah Veeranoot Nissapatorn Jaya Seelan Sathya Seelan Homathevi Rahman Nor Azizun Rusdi Nazirah Mustaffa Layane Elbehairy Mazdida Sulaiman Tags: Review Source Type: research

Molecules, Vol. 28, Pages 5653: Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings
This study identified twelve Plectranthus species indicated for the treatment of different inflammatory conditions, such as wounds, fever, bronchitis, abscess, asthma, hepatitis, labyrinthitis, tonsillitis, and uterine inflammation. The indications for pain conditions included headache, sore throat, heartburn, menstrual cramp, colic, toothache, stomachache, migraine, chest pain, abdominal pain, local pain, labor pain, and recurring pain. Among the listed species, ten plants were found to be used according to traditional knowledge, although only four of them have been experimentally studied. When assessing the methodologica...
Source: Molecules - July 26, 2023 Category: Chemistry Authors: Maysa de Oliveira Barbosa Polrat Wilairatana Giovana Mendes de Lacerda Leite Gyllyandeson de Ara újo Delmondes Lucas Yure Santos da Silva Silvio Caetano Alves J únior Lindaiane Bezerra Rodrigues Dantas Daniel Souza Bezerra Izabel Cristina Santiago Lemos Tags: Systematic Review Source Type: research

Molecules, Vol. 28, Pages 5624: Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer & rsquo;s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids
Molecules, Vol. 28, Pages 5624: Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids Molecules doi: 10.3390/molecules28155624 Authors: Ryszard Pluta Barbara Miziak Stanisław J. Czuczwar Neurodegeneration of the brain after ischemia is a major cause of severe, long-term disability, dementia, and mortality, which is a global problem. These phenomena are attributed to excitotoxicity, changes in the blood–brain barrier, neuroinflammation, oxidative stress, vasoconstriction, cerebral amyloid angiopathy,...
Source: Molecules - July 25, 2023 Category: Chemistry Authors: Ryszard Pluta Barbara Miziak Stanis ław J. Czuczwar Tags: Review Source Type: research

Molecules, Vol. 28, Pages 5587: Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer
Brasil André Salim Khayat Gastric cancer is one of the most frequent types of neoplasms worldwide, usually presenting as aggressive and difficult-to-manage tumors. The search for new structures with anticancer potential encompasses a vast research field in which natural products arise as promising alternatives. In this scenario, piperine, an alkaloid of the Piper species, has received attention due to its biological activity, including anticancer attributes. The present work proposes three heating-independent, reliable, low-cost, and selective methods for obtaining piperine from Piper nigrum L. (Black pepper). Elect...
Source: Molecules - July 22, 2023 Category: Chemistry Authors: Ingryd Nayara de Farias Ramos Monique Feitosa da Silva Jefferson Marcio Sanches Lopes Jordy Neves Cruz Fabrine Silva Alves Jos é de Arimatéia Rodrigues do Rego Marcondes Lima da Costa Paulo Pimentel de Assump ção Davi do Socorro Barros Brasil Andr é Tags: Article Source Type: research

Molecules, Vol. 28, Pages 5540: Risk Assessment of Chlorogenic and Isochlorogenic Acids in Coffee By-Products
The objective of this review was to assess the potential health risks associated with the oral consumption of coffee by-products containing chlorogenic and isochlorogenic acids, considering both acute and chronic exposure. An electronic literature search was conducted, revealing that 5-caffeoylquinic acid (5-CQA) and 3,5-dicaffeoylquinic acid (3,5-DCQA) are the major chlorogenic acids found in coffee by-products. Toxicological, pharmacokinetic, and clinical data from animal and human studies were available for the assessment, which indicated no significant evidence of toxic or adverse effects following acute oral exposure....
Source: Molecules - July 20, 2023 Category: Chemistry Authors: Sascha Behne Heike Franke Steffen Schwarz Dirk W. Lachenmeier Tags: Review Source Type: research

Molecules, Vol. 28, Pages 5413: An Estimation of the Antiviral Activity and Toxicity of Biologically Active Substances Obtained from the Raw Materials of Artemisia cina Berg. In Vitro and In Vivo
kezhanova Species of the genus Artemisia are well known for their use as ingredients in ancient medicine. The advantage of using plant extracts compared to individual pharmaceutical ingredients is the rate of adaptation of the pathogenic microorganisms to the drug. Due to the rapid development of multidrug-resistance in microorganisms in the field, it is essential to search for novel, effective drugs with low toxicity. Therefore, the purpose of this study was to isolate and study the biologically active substances obtained from various substances in the raw materials of Artemisia cina Berg. The identification of the ma...
Source: Molecules - July 14, 2023 Category: Chemistry Authors: Murat Zhurinov Dmitriy Berillo Kulzada Begalinovna Bazhykova Kayrolla Dyusenbaevich Rakhimov Tolkyn Bekezhanova Tags: Article Source Type: research

Molecules, Vol. 28, Pages 5314: Coriandrum sativum and Its Utility in Psychiatric Disorders
ra-Ruiz The negative impact on worldwide social well-being by the increasing rate of psychiatric diseases has led to a continuous new drug search. Even though the current therapeutic options exert their activity on multiple neurological targets, these have various adverse effects, causing treatment abandonment. Recent research has shown that Coriandrum sativum offers a rich source of metabolites, mainly terpenes and flavonoids, as useful agents against central nervous system disorders, with remarkable in vitro and in vivo activities on models related to these pathologies. Furthermore, studies have revealed that some co...
Source: Molecules - July 10, 2023 Category: Chemistry Authors: Anislada Santib áñez Enrique Jim énez-Ferrer Paola Isabel Angulo-Bejarano Ashutosh Sharma Maribel Herrera-Ruiz Tags: Review Source Type: research

Molecules, Vol. 28, Pages 5293: Deep Eutectic Solvents: Properties and Applications in CO2 Separation
ska Nowadays, many researchers are focused on finding a solution to the problem of global warming. Carbon dioxide is considered to be responsible for the “greenhouse” effect. The largest global emission of industrial CO2 comes from fossil fuel combustion, which makes power plants the perfect point source targets for immediate CO2 emission reductions. A state-of-the-art method for capturing carbon dioxide is chemical absorption using an aqueous solution of alkanolamines, most frequently a 30% wt. solution of monoethanolamine (MEA). Unfortunately, the usage of alkanolamines has a number of dra...
Source: Molecules - July 8, 2023 Category: Chemistry Authors: Iwona Cichowska-Kopczy ńska Bartosz Nowosielski Dorota Warmi ńska Tags: Review Source Type: research

Molecules, Vol. 28, Pages 5004: The Progress on Magnetic Material Thin Films Prepared Using Polymer-Assisted Deposition
Xiang Polymer-assisted deposition (PAD) has been widely used in the preparation of high-quality oxides and sulfides for basic research and applications. Specifically, diverse PAD-prepared magnetic material thin films such as ZnO, Ga2O3, SrRuO3, LaCoO3, LaMnO3, Y3Fe5O12, MoS2, MoSe2, and ReS2 thin films have been grown, in which thickness-dependent, strain-modulated, doping-mediated, and/or morphology-dependent room-temperature ferromagnetism (RTFM) have been explored. Inspired by the discovery of intrinsic low-temperature FM in two-dimensional (2D) systems prepared using mechanical exfoliation, the search for more conv...
Source: Molecules - June 26, 2023 Category: Chemistry Authors: Hongtao Ren Jing Zhong Gang Xiang Tags: Review Source Type: research

Molecules, Vol. 28, Pages 4977: Novel Isosteviol-Based FXa Inhibitors: Molecular Modeling, In Silico Design and Docking Simulation
n Koba Direct oral anticoagulants are an important and relatively new class of synthetic anticoagulant drugs commonly used for the pharmacotherapy of thromboembolic disorders. However, they still have some limitations and serious side effects, which continuously encourage medicinal chemists to search for new active compounds acting as human-activated coagulation factor X (FXa) inhibitors. Isosteviol is a nontoxic hydrolysis product of naturally occurring stevioside and possesses a wide range of therapeutic properties, including anticoagulant activity. The present contribution describes the in silico design of novel oxi...
Source: Molecules - June 24, 2023 Category: Chemistry Authors: Marcin Gackowski Burhanuddin Madriwala Renata Studzi ńska Marcin Koba Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4951: The Finally Rewarding Search for A Cytotoxic Isosteviol Derivative
l Csuk Acid hydrolysis of stevioside resulted in a 63% yield of isosteviol (1), which served as a starting material for the preparation of numerous amides. These compounds were tested for cytotoxic activity, employing a panel of human tumor cell lines, and almost all amides were found to be non-cytotoxic. Only the combination of isosteviol, a (homo)-piperazinyl spacer and rhodamine B or rhodamine 101 unit proved to be particularly suitable. These spacered rhodamine conjugates exhibited cytotoxic activity in the sub-micromolar concentration range. In this regard, the homopiperazinyl-spacered derivatives were found to...
Source: Molecules - June 23, 2023 Category: Chemistry Authors: Heisig Heise Hoenke Str öhl Csuk Tags: Article Source Type: research