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Investigation of the Therapeutic Effect and Mechanism of Holographic Meridian Scraping Therapy on Knee Osteoarthritis
CONCLUSIONS: Combining holographic meridian scraping therapy with celecoxib effectively treats KOA and significantly improves patient conditions, along with reductions in serum TNF-α and IL-1β levels.PMID:37573584
Source: Alternative Therapies in Health and Medicine - August 13, 2023 Category: Complementary Medicine Authors: Yulong Deng Man Zhang Wei Li Shuguo Cui Junge Dong Chenglin Mu Zhiyuan Zheng Jiaxiang Yang Source Type: research
Acupoint Thread Embedding Combined With Wenshen Bugu Decoction for the Treatment of Aromatase Inhibitor-Associated Musculoskeletal Symptom Among Postmenopausal Breast Cancer Patients: Study Protocol of a Randomized Controlled Trial
This study will be performed to determine whether acupoint thread embedding (ATE) combined with Wenshen Bugu Decoction can effectively treat AIMSS, so as to improve the AIs medication compliance of postmenopausal breast cancer patients.METHODS: This study will utilize a randomized, 2 parallel groups controlled trial design. A total of 128 eligible postmenopausal breast cancer women with AIMSS will be randomized to receive a 12-week treatment with Wenshen Bugu Decoction alone (control group) or in combination with ATE (treatment group) in a 1:1 ratio. The primary outcome will be the 12 week Brief Pain Inventory Worst Pain (...
Source: Cancer Control - August 11, 2023 Category: Cancer & Oncology Authors: Xuan Zou Zi-Yi Chen Yu-Han Yang Yu Qiao Shu-Jin He Qiong Li Wei-Li Chen Xin-Yue Zhang Si-Yu Li Shan-Yan Sha Min-Hao Hu Xi-Yin Zhang Ming-Ju Yang Rui-Ping Wang Huan-Gan Wu Yin Shi Xiao-Hong Xue Ya-Jie Ji Source Type: research
Sintilimab plus bevacizumab, oxaliplatin and capecitabine as first-line therapy in RAS-mutant, microsatellite stable, unresectable metastatic colorectal cancer: an open-label, single-arm, phase II trial
This study aims to assess the preliminary anti-tumor activity and safety of sintilimab plus bevacizumab, oxaliplatin and capecitabine as a treatment option for patients with RAS-mutant MSS mCRC.METHODS: This study was an open-label, single-arm, phase II trial in China. Patients with unresectable, RAS-mutant and MSS metastatic colorectal adenocarcinoma received treatment by intravenous sintilimab (200 mg, day 1) plus bevacizumab (7.5 mg/kg, day 1), oxaliplatin (135 mg/m2, day 1) and oral capecitabine (1 g/m2, day 1-14) in each 21-day cycle. The primary endpoints included objective response rate (ORR) and adverse events. Bio...
Source: Cancer Control - August 9, 2023 Category: Cancer & Oncology Authors: Xuefeng Fang Ning Zhu Chenhan Zhong Liuhong Wang Jun Li Shanshan Weng Hanguang Hu Caixia Dong Dan Li Yongmao Song Dong Xu Jianwei Wang Lifeng Sun Jian Wang Zhanhuai Wang Hongfeng Cao Xiujun Liao Ningjuan Yu Qian Xiao Mi Mi Suzhan Zhang Kefeng Ding Ying Yu Source Type: research
Clinical and Radiological Comparison of Single and Double Intra-articular Injection of Adipose-Derived Stromal Vascular Fraction for Knee Osteoarthritis
In conclusion, double injections may provide more satisfactory treatment outcomes in patients with severe varus knee alignment. This clinical trial is registered in the Japanese Ministry of Health, Labour and Welfare (URL: https://saiseiiryo.mhlw.go.jp/published_plan/index/2) with the registration name "Cell transplantation therapy for osteoarthritis using autologous subcutaneous adipose tissue-derived regenerative (stem) cells (ADRCs)," and the registration number was "PB5160012."PMID:37551027 | PMC:PMC10411282 | DOI:10.1177/09636897231190175
Source: Cell Transplantation - August 8, 2023 Category: Cytology Authors: Masahiro Fujita Tomoyuki Matsumoto Satoshi Sobajima Masanori Tsubosaka Takehiko Matsushita Hideki Iwaguro Ryosuke Kuroda Source Type: research
