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Vaccination: Veterinary Vaccinations
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Recent advances in genome editing of bloodstream forms of Trypanosoma congolense using CRISPR-Cas9 ribonucleoproteins: Proof of concept
We present an efficient, reproducible and stable CRISPR-Cas9 genome editing system for use in Tc bloodstream forms (Tc-BSF). This plasmid-free system is based on transient expression of Cas9 protein and the use of a ribonucleoprotein formed by the Cas9 and sgRNA complex. This is the first proof of concept of genome editing using CRISPR-Cas9 ribonucleoproteins on Tc-BSF. This adapted protocol enriches the "toolbox" for the functional study of genes of interest in blood forms of the Trypanosoma congolense. This proof of concept is an important step for the scientific community working on the study of trypanosomes and opens u...
Source: Experimental Parasitology - July 29, 2023 Category: Parasitology Authors: C écile Minet Isabelle Chantal David Berthier Source Type: research
3Rs implementation in veterinary vaccine batch-release testing: Current state-of-the-art and future opportunities. A webinar and workshop report
Biologicals. 2023 Jul 27;83:101695. doi: 10.1016/j.biologicals.2023.101695. Online ahead of print.ABSTRACTRegulatory authorities require veterinary batch-release testing to confirm vaccine potency and safety, but these tests have traditionally relied on large numbers of laboratory animals. Advances in vaccine research and development offer increasing opportunities to replace in vivo testing, and some stakeholders have made significant progress in incorporating 3Rs elements in quality control strategies. A three-part event series entitled "3Rs Implementation in Veterinary Vaccine Batch-Release Testing: Current state-of-the-...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 29, 2023 Category: Biotechnology Authors: Laura Viviani Elisabeth Balks Sonja Beken Anna-Maria Brady Rick Clayton Florence Cliquet Liys Desmayanti Silvia Fragoeiro Terrie Jo Hamtak David John Carmen Jungba ëck M Kalaivani Imke Kross Catherine Lang Ni Made Ria Isriyanthi Laurent Mallet Catherine Source Type: research
Recent advances in genome editing of bloodstream forms of Trypanosoma congolense using CRISPR-Cas9 ribonucleoproteins: Proof of concept
We present an efficient, reproducible and stable CRISPR-Cas9 genome editing system for use in Tc bloodstream forms (Tc-BSF). This plasmid-free system is based on transient expression of Cas9 protein and the use of a ribonucleoprotein formed by the Cas9 and sgRNA complex. This is the first proof of concept of genome editing using CRISPR-Cas9 ribonucleoproteins on Tc-BSF. This adapted protocol enriches the "toolbox" for the functional study of genes of interest in blood forms of the Trypanosoma congolense. This proof of concept is an important step for the scientific community working on the study of trypanosomes and opens u...
Source: Experimental Parasitology - July 29, 2023 Category: Parasitology Authors: C écile Minet Isabelle Chantal David Berthier Source Type: research
3Rs implementation in veterinary vaccine batch-release testing: Current state-of-the-art and future opportunities. A webinar and workshop report
Biologicals. 2023 Jul 27;83:101695. doi: 10.1016/j.biologicals.2023.101695. Online ahead of print.ABSTRACTRegulatory authorities require veterinary batch-release testing to confirm vaccine potency and safety, but these tests have traditionally relied on large numbers of laboratory animals. Advances in vaccine research and development offer increasing opportunities to replace in vivo testing, and some stakeholders have made significant progress in incorporating 3Rs elements in quality control strategies. A three-part event series entitled "3Rs Implementation in Veterinary Vaccine Batch-Release Testing: Current state-of-the-...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 29, 2023 Category: Biotechnology Authors: Laura Viviani Elisabeth Balks Sonja Beken Anna-Maria Brady Rick Clayton Florence Cliquet Liys Desmayanti Silvia Fragoeiro Terrie Jo Hamtak David John Carmen Jungba ëck M Kalaivani Imke Kross Catherine Lang Ni Made Ria Isriyanthi Laurent Mallet Catherine Source Type: research
An Immunoinformatics-Based Study of Mycobacterium tuberculosis Region of Difference-2 Uncharacterized Protein (Rv1987) as a Potential Subunit Vaccine Candidate for Preliminary Ex Vivo Analysis
Appl Biochem Biotechnol. 2023 Jul 27. doi: 10.1007/s12010-023-04658-9. Online ahead of print.ABSTRACTMycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis and develops resistance to many of the existing drugs. The sole licensed TB vaccine, BCG, is unable to provide a comprehensive defense. So, it is crucial to maintain the immunological response to eliminate tuberculosis. Our previous in silico study reported five uncharacterized proteins as potential vaccine antigens. In this article, we considered the uncharacterized Mtb H37Rv regions of difference (RD-2) Rv1987 protein as a promising vaccine candidat...
Source: Applied Biochemistry and Biotechnology - July 27, 2023 Category: Biochemistry Authors: Aregitu Mekuriaw Arega Ajit Kumar Dhal Kali Prasad Pattanaik Sasmita Nayak Rajani Kanta Mahapatra Source Type: research
