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Vaccination: Malaria Vaccine
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Total 26 results found since Jan 2013.
Biological activity of 1,2,3-triazole-2-amino-1,4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control
Eur J Med Chem. 2023 Apr 18;255:115400. doi: 10.1016/j.ejmech.2023.115400. Online ahead of print.ABSTRACTMalaria can be caused by several Plasmodium species and the development of an effective vaccine is challenging. Currently, the most effective tool to control the disease is the administration of specific chemotherapy; however, resistance to the frontline antimalarials is one of the major problems in malaria control and thus the development of new drugs becomes urgent. The study presented here sought to evaluate the antimalarial activities of compounds derived from 2-amino-1,4-naphthoquinones containing 1,2,3-triazole us...
Source: European Journal of Medicinal Chemistry - May 2, 2023 Category: Chemistry Authors: Renata Maria Costa Souza Lilian Maria Lapa Montenegro Pimentel Laryssa Kathleen Mendon ça Ferreira Val éria Rêgo Alves Pereira Aline Caroline Da Silva Santos Willyenne Mar ília Dantas Carla Jasmine Oliveira Silva Ramayana Morais De Medeiros Brito Jos Source Type: research
Immunomodulatory role of Th17 pathway in experimental visceral leishmaniasis
Immunobiology. 2021 Oct 25;226(6):152148. doi: 10.1016/j.imbio.2021.152148. Online ahead of print.ABSTRACTVisceral leishmaniasis (VL) or Kala-azar is a vector borne protozoan infection caused by Leishmania donovani in the Indian subcontinent mainly India, Nepal and Bangladesh. It is a major public health problem in these countries mostly affecting the socio-economically poor population. Leishmaniasis ranks the third most important disease after malaria and filariasis but is still considered as one of the neglected tropical diseases of the world. For development of better therapeutic agents and effective vaccine against VL,...
Source: Immunobiology - November 13, 2021 Category: Allergy & Immunology Authors: Rasmita Khatonier Giasuddin Ahmed Pallab Sarmah Kanwar Narain Abdul Mabood Khan Source Type: research
In vitro antimalarial activity of inhibitors of the human GTPase Rac1
Antimicrob Agents Chemother. 2021 Nov 1:AAC0149821. doi: 10.1128/AAC.01498-21. Online ahead of print.ABSTRACTMalaria accounts for millions of cases and thousands of deaths every year. In the absence of an effective vaccine, drugs are still the most important tool in the fight against the disease. Plasmodium parasites developed resistance for all the classes of known antimalarial drugs. Thus, the search for antimalarial drugs with novel mechanisms of action is compelling. The human GTPase Rac1 plays a role in parasite invasion of the host cell in many intracellular pathogens. Also in Plasmodium falciparum, it was suggested ...
Source: Antimicrobial Agents and Chemotherapy - November 1, 2021 Category: Microbiology Authors: Silvia Parapini Silvio Paone Emanuela Erba Loredana Cavicchini Manoochehr Pourshaban Francesco Celani Alessandro Contini Sarah D'Alessandro Anna Olivieri Source Type: research
Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology
Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to prevent the disease. Drug chemotherapy has a strong historical link to the use of traditional plant infusions and other natural products in various cultures. The research based on such knowledge has yielded two drugs in medicine: the alkaloid quinine from Cinchona species, native in the Amazon highland rain forest in South America, and artemisinin from Artemisia annua, a spe...
Source: Frontiers in Pharmacology - September 22, 2021 Category: Drugs & Pharmacology Source Type: research
Inhibitory compounds targeting < em > Plasmodium falciparum < /em > Gyrase B
Antimicrob Agents Chemother. 2021 Aug 2:AAC0026721. doi: 10.1128/AAC.00267-21. Online ahead of print.ABSTRACTMalaria persists as a major health problem due to the spread of drug resistance and the lack of effective vaccines. DNA gyrase is a well-validated and extremely effective therapeutic target in bacteria, and it is also known to be present in the apicoplast of malarial species including Plasmodium falciparum. This raises the possibility that it could be a useful target for novel antimalarials. To date, characterisation and screening of this gyrase has been hampered by difficulties in cloning and purification of the Gy...
Source: Antimicrobial Agents and Chemotherapy - August 2, 2021 Category: Microbiology Authors: Zuzanna Pakosz Ting-Yu Lin Elizabeth Michalczyk Soshichiro Nagano Jonathan Gardiner Heddle Source Type: research
