Filtered By:
Specialty: Chemistry
Vaccination: Malaria Vaccine
This page shows you your search results in order of date.
Order by Relevance | Date
Total 27 results found since Jan 2013.
Potential drugs in COVID-19 management
Curr Med Chem. 2023 Jul 17. doi: 10.2174/0929867331666230717154101. Online ahead of print.ABSTRACTThe SARS-CoV-2 virus first emerged in China in December 2019 and quickly spread worldwide. Despite the absence of a vaccination or authorized drug specifically developed to combat this infection, certain medications recommended for other diseases have shown potential effectiveness in treating COVID-19, although without definitive confirmation. This review aims to evaluate the existing literature on the efficacy of these medications against COVID-19. The review encompasses various potential treatments, including antiviral medic...
Source: Current Medicinal Chemistry - July 18, 2023 Category: Chemistry Authors: Amin Gasmi Sadaf Noor Alain Menzel Nataliia Khanyk Yuliya Semenova Roman Lysiuk Nataliya Beley Lidiia Bolibrukh Asma Gasmi Benahmed Olha Storchylo Geir Bj ørklund Source Type: research
Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria therapeutics
Eur J Med Chem. 2023 Jun 12;258:115564. doi: 10.1016/j.ejmech.2023.115564. Online ahead of print.ABSTRACTMalaria is a widespread infectious disease, causing nearly 247 million cases in 2021. The absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the currently used antimalarials are the major challenges to malaria eradication efforts. To design and develop novel antimalarials, we synthesized a series of 4,7-dichloroquinoline and methyltriazolopyrimidine analogues using a multi-component Petasis reaction. The synthesized molecules (11-31) were screened for in-vitro antimalarial activity ag...
Source: European Journal of Medicinal Chemistry - June 15, 2023 Category: Chemistry Authors: Hari Madhav Tarosh S Patel Zeba Rizvi G Srinivas Reddy Abdur Rahman Md Ataur Rahman Saiema Ahmedi Sadaf Fatima Kanika Saxena Nikhat Manzoor Souvik Bhattacharjee Bharat C Dixit Puran Singh Sijwali Nasimul Hoda Source Type: research
Biological activity of 1,2,3-triazole-2-amino-1,4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control
Eur J Med Chem. 2023 Apr 18;255:115400. doi: 10.1016/j.ejmech.2023.115400. Online ahead of print.ABSTRACTMalaria can be caused by several Plasmodium species and the development of an effective vaccine is challenging. Currently, the most effective tool to control the disease is the administration of specific chemotherapy; however, resistance to the frontline antimalarials is one of the major problems in malaria control and thus the development of new drugs becomes urgent. The study presented here sought to evaluate the antimalarial activities of compounds derived from 2-amino-1,4-naphthoquinones containing 1,2,3-triazole us...
Source: European Journal of Medicinal Chemistry - May 2, 2023 Category: Chemistry Authors: Renata Maria Costa Souza Lilian Maria Lapa Montenegro Pimentel Laryssa Kathleen Mendon ça Ferreira Val éria Rêgo Alves Pereira Aline Caroline Da Silva Santos Willyenne Mar ília Dantas Carla Jasmine Oliveira Silva Ramayana Morais De Medeiros Brito Jos Source Type: research
Extracellular Vesicles derived from Plasmodium-infected Hosts as Stimuli of ''Trained'' Innate Immunity
Curr Med Chem. 2023 Feb 7. doi: 10.2174/0929867330666230207115157. Online ahead of print.ABSTRACTAlthough the burden of malaria has been successfully controlled globally, this disease remains a major public health issue. To date, neither existing drugs nor vaccines against malaria are sufficient in eliminating malaria worldwide. To achieve the eradication of malaria by 2040, effective interventions targeting all Plasmodium species are urgently needed. As the cornerstone of vaccine design, immune memory serves a significant role in the host's defense against Plasmodium infections. It has long been considered that innate imm...
Source: Current Medicinal Chemistry - February 7, 2023 Category: Chemistry Authors: Jin-Guang Chen Yun-Ting Du Chang-Hui Guan Hua-Yu Fan Yang-Ai Liu Ting Wang Xin Li Guang Chen Source Type: research
Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents
Eur J Med Chem. 2022 Apr 30;238:114408. doi: 10.1016/j.ejmech.2022.114408. Online ahead of print.ABSTRACTMalaria remains one of the major health problems worldwide. The lack of an effective vaccine and the increasing resistance of Plasmodium to the approved antimalarial drugs demands the development of novel antiplasmodial agents that can effectively prevent and/or treat this disease. Harmiquins represent hybrids that combine two moieties with different mechanisms of antiplasmodial activity in one molecule, i.e., a chloroquine (CQ) scaffold, known to inhibit heme polymerization and a β-carboline ring capable of binding to...
Source: European Journal of Medicinal Chemistry - May 13, 2022 Category: Chemistry Authors: Goran Poje Lais Pessanha de Carvalho Jana Held Diana Moita Miguel Prud êncio Ivana Perkovi ć Tana Tandari ć Robert Vianello Zrinka Raji ć Source Type: research
Neglected Tropical Diseases (NTDs) and COVID-19 pandemic in Africa: Special focus on control strategies
Comb Chem High Throughput Screen. 2022 Apr 27. doi: 10.2174/1386207325666220427123349. Online ahead of print.ABSTRACTNeglected Tropical Diseases (NTDs) are a group of twenty (20) chronic, communicable, infectious diseases endemic to the tropics and sub-tropics climate countries which are intimately associated with poverty, poor sanitation, limited clean water, and healthcare delivery; and dwellers live in proximity to pathogens and diseases vectors. The pathogens are protozoans, bacteria, helminths, fungi, and viruses. NTDs currently affects about one billion people globally, out of which 500 million are Africans living in...
Source: Combinatorial Chemistry and High Throughput Screening - May 1, 2022 Category: Chemistry Authors: Abdullahi Tunde Aborode Emmanuel Adebowale Fajemisin Emmanuel Ademola Aiyenuro Muhammad Alakitan Matthew Olaide Ariwoola Jegede Oluwatoyin Imisioluwa Raheemt Rafiu Athanasios Alexiou Source Type: research
