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Specialty: Chemistry
Therapy: Statin Therapy
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Total 178 results found since Jan 2013.
Statins and portal hypertension: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: Treatment with statins did not decrease significantly portal hypertension.PMID:37723637 | DOI:10.2174/0929867331666230918114451
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Tannaz Jamialahmadi Željko Reiner Maryam Matbou Riahi Seyed Ahmad Emami Zahra Tayarani-Najaran Sepideh Salehabadi Prashant Kesharwani Khalid Al-Rasadi Amirhossein Sahebkar Source Type: research
Effect of Statins on Superoxide Dismutase Level: A Systematic Review
CONCLUSION: Our systematic review suggests that treatment with statins has a positive effect on SOD activity. However, evidence from further randomized controlled trials is required to confirm the potential antioxidant effect of statin therapy.PMID:37653630 | DOI:10.2174/0929867331666230831145809
Source: Current Medicinal Chemistry - September 1, 2023 Category: Chemistry Authors: Mahla Daliri Luis E Simental-Mend ía Tannaz Jamialahmadi Prashant Kesharwani Željko Reiner Amirhossein Sahebkar Source Type: research
Statins as a Potential Treatment for Non-Alcoholic Fatty Liver Disease: Target Deconvolution using Protein-protein Interaction Network Analysis
CONCLUSIONS: Simvastatin has the most impact on NAFLD-related genes versus other statins.PMID:37644746 | DOI:10.2174/0929867331666230829164832
Source: Current Medicinal Chemistry - August 30, 2023 Category: Chemistry Authors: Ali Mahmoudi Alexandra E Butler Alexander N Orekhov Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research
Statins, allies against antibiotic resistance?
Curr Med Chem. 2023 Aug 29. doi: 10.2174/0929867331666230829141301. Online ahead of print.ABSTRACTDue to the ever-increasing rate of antibacterial resistance, the search for effective antibacterial agents has become imperative. Researchers have investigated the potential antimicrobial properties of various classes of nonantibiotic drugs. Statins are a group of antihyperlipidemic drugs with several cholesterol-independent effects, including anti-inflammatory, immune-modulating, antioxidant, and antibacterial effects. In vitro and in vivo studies have demonstrated the antibacterial properties of statins against various gram-...
Source: Current Medicinal Chemistry - August 30, 2023 Category: Chemistry Authors: Mohammad Abavisani Melika Hoseinzadeh Reza Khayami Mansoor Kodori Saman Soleimanpour Amirhossein Sahebkar Source Type: research
Statins as a Potential Treatment for Non-Alcoholic Fatty Liver Disease: Target Deconvolution using Protein-protein Interaction Network Analysis
CONCLUSIONS: Simvastatin has the most impact on NAFLD-related genes versus other statins.PMID:37644746 | DOI:10.2174/0929867331666230829164832
Source: Current Medicinal Chemistry - August 30, 2023 Category: Chemistry Authors: Ali Mahmoudi Alexandra E Butler Alexander N Orekhov Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research
Statins, allies against antibiotic resistance?
Curr Med Chem. 2023 Aug 29. doi: 10.2174/0929867331666230829141301. Online ahead of print.ABSTRACTDue to the ever-increasing rate of antibacterial resistance, the search for effective antibacterial agents has become imperative. Researchers have investigated the potential antimicrobial properties of various classes of nonantibiotic drugs. Statins are a group of antihyperlipidemic drugs with several cholesterol-independent effects, including anti-inflammatory, immune-modulating, antioxidant, and antibacterial effects. In vitro and in vivo studies have demonstrated the antibacterial properties of statins against various gram-...
Source: Current Medicinal Chemistry - August 30, 2023 Category: Chemistry Authors: Mohammad Abavisani Melika Hoseinzadeh Reza Khayami Mansoor Kodori Saman Soleimanpour Amirhossein Sahebkar Source Type: research
Using stable carbon isotope ratio analysis to detect adulteration in red yeast rice dietary supplements
Talanta. 2023 Aug 23;266(Pt 2):125076. doi: 10.1016/j.talanta.2023.125076. Online ahead of print.ABSTRACTRed yeast rice (RYR) is marketed as a dietary supplement because it contains natural 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins), including monacolin K. However, there is concern that some RYR supplements may be adulterated with the pharmaceutical drug lovastatin to enhance health claims. We have developed an optimized method to isolate monacolin K/lovastatin from complex RYR dietary supplement matrices to then test for adulteration in RYR supplements using stable carbon isotope (δ13C) analysis...
Source: Talanta - August 25, 2023 Category: Chemistry Authors: Kristen M Hannon Joshua D Sabala Madhavi Mantha Lisa M Lorenz John P Roetting Ii Matteo Perini Silvia Pianezze Kevin M Kubachka Source Type: research
Microextraction based on liquid-solid phase transition of benzoic acid: Extraction of statins from human urine followed by chromatographic analysis
Talanta. 2023 Aug 18;266(Pt 2):125088. doi: 10.1016/j.talanta.2023.125088. Online ahead of print.ABSTRACTHerein, a microextraction method was reported based on the liquid-solid phase transition of benzoic acid to quantify two statins, namely lovastatin and simvastatin in authentic human urine. The principle of the method is based on the phase transition of benzoic acid by altering the pH of the sample solution enabling efficient dispersion and phase separation in one step. Due to the moderate melting point of benzoic acid, its solidification is performed at ambient temperature without the need for sample cooling. Various e...
Source: Talanta - August 25, 2023 Category: Chemistry Authors: Natalia Manousi Paraskevas D Tzanavaras Constantinos K Zacharis Source Type: research
