• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Hiding in plain sight: an epitope-based strategy for a subunit malaria vaccine
Trends Parasitol. 2023 Sep 6:S1471-4922(23)00197-6. doi: 10.1016/j.pt.2023.08.006. Online ahead of print.ABSTRACTRecent data suggest that approaches to developing a subunit blood-stage malaria vaccine may be misdirected. While antigenic polymorphism is recognized as a challenge, efforts to counter this have primarily involved enhancing the quantity and quality of antibody with potent adjuvants, identifying conserved target proteins, or combining multiple antigens to broaden the immune response. However, paradoxically, evidence has emerged that narrowing, rather than broadening, the immune response may be required to obtain...
Source: Trends in Parasitology - September 8, 2023 Category: Parasitology Authors: Michael F Good Stephanie K Yanow Source Type: research

Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein
Trends Parasitol. 2023 Jul 21:S1471-4922(23)00147-2. doi: 10.1016/j.pt.2023.06.011. Online ahead of print.ABSTRACTMalaria caused by the Plasmodium vivax parasite is a major global health burden. Immunity against blood-stage infection reduces parasitemia and disease severity. Duffy-binding protein (DBP) is the primary parasite protein responsible for the invasion of red blood cells and it is a leading subunit vaccine candidate. An effective vaccine, however, is still lacking despite decades of interest in DBP as a vaccine candidate. This review discusses the reasons for targeting DBP, the challenges associated with developi...
Source: Trends in Parasitology - July 22, 2023 Category: Parasitology Authors: Thayne H Dickey Niraj H Tolia Source Type: research

Plasmodium DDI1 is a potential therapeutic target and important chromatin-associated protein
Int J Parasitol. 2023 Jan 16:S0020-7519(23)00013-9. doi: 10.1016/j.ijpara.2022.11.007. Online ahead of print.ABSTRACTDNA damage inducible 1 protein (DDI1) is involved in a variety of cellular processes including proteasomal degradation of specific proteins. All DDI1 proteins contain a ubiquitin-like (UBL) domain and a retroviral protease (RVP) domain. Some DDI1 proteins also contain a ubiquitin-associated (UBA) domain. The three domains confer distinct activities to DDI1 proteins. The presence of a RVP domain makes DDI1 a potential target of HIV protease inhibitors, which also block the development of malaria parasites. He...
Source: International Journal for Parasitology - January 19, 2023 Category: Parasitology Authors: Nandita Tanneru M Angel Nivya Navin Adhikari Kanika Saxena Zeba Rizvi Renu Sudhakar Amit Kumar Nagwani None Atul Faisal Mohammed Abdul Al-Nihmi Kota Arun Kumar Puran Singh Sijwali Source Type: research

Housebreaking Plasmodium parasites leave their fingerprints at the door
Trends Parasitol. 2022 Sep 23:S1471-4922(22)00209-4. doi: 10.1016/j.pt.2022.09.005. Online ahead of print.ABSTRACTProtective antibodies against Plasmodium falciparum merozoite antigens, including EBA-175, can inhibit erythrocyte invasion. New data from Musasia et al. indicate that these antibodies can also trigger antibody-dependent phagocytosis of ring-infected and uninfected erythrocytes and that this correlates with protection from malaria. This provides a new pathway for vaccine design.PMID:36163104 | DOI:10.1016/j.pt.2022.09.005
Source: Trends in Parasitology - September 26, 2022 Category: Parasitology Authors: Lara Bardtke Ian A Cockburn Source Type: research

Pages: 1  2  3  4  5  6