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Specialty: Neurosurgery
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Total 2082 results found since Jan 2013.

Association between immunohistochemical markers and tumor progression following resection of spinal chordomas: a multicenter study
CONCLUSIONS: These IHC variables with tree-based machine learning tools successfully demonstrate a high capacity to identify a patient's tumor progression pattern with an accuracy of 66%. Pancytokeratin, EMA, cytokeratin A1/A3, and S100 protein were the IHC drivers of a low tumor progression. This shows the power of machine learning algorithms in analyzing and predicting outcomes of rare conditions in a small sample size.PMID:37728388 | DOI:10.3171/2023.6.SPINE23348
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Abdul Karim Ghaith Oluwaseun O Akinduro Carlos Perez-Vega Antonio Bon Nieves Kingsley Abode-Iyamah Naresh Patel Maziyar Kalani Michelle J Clarke Peter Rose Mohamad Bydon Source Type: research

Economic burden of nonoperative treatment of adult spinal deformity
CONCLUSIONS: Patients with ASD undergoing operative treatment at baseline had greater sagittal deformity and greater improvement in health-related quality of life postoperatively compared to patients treated nonoperatively. Additionally, patients in the nonoperative cohort overall had an increase in ODI and did not show improvement in utility gained. Patients in the nonoperative cohort who had low disability and sagittal deformity underwent successful maintenance and cost-effective treatment.PMID:37728175 | DOI:10.3171/2023.7.SPINE23195
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Peter G Passias Waleed Ahmad Pooja Dave Renaud Lafage Virginie Lafage Jamshaid Mir Eric O Klineberg Khaled M Kabeish Jeffrey L Gum Breton G Line Robert Hart Douglas Burton Justin S Smith Christopher P Ames Christopher I Shaffrey Frank Schwab Richard Hosti Source Type: research

Association between immunohistochemical markers and tumor progression following resection of spinal chordomas: a multicenter study
CONCLUSIONS: These IHC variables with tree-based machine learning tools successfully demonstrate a high capacity to identify a patient's tumor progression pattern with an accuracy of 66%. Pancytokeratin, EMA, cytokeratin A1/A3, and S100 protein were the IHC drivers of a low tumor progression. This shows the power of machine learning algorithms in analyzing and predicting outcomes of rare conditions in a small sample size.PMID:37728388 | DOI:10.3171/2023.6.SPINE23348
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Abdul Karim Ghaith Oluwaseun O Akinduro Carlos Perez-Vega Antonio Bon Nieves Kingsley Abode-Iyamah Naresh Patel Maziyar Kalani Michelle J Clarke Peter Rose Mohamad Bydon Source Type: research

Economic burden of nonoperative treatment of adult spinal deformity
CONCLUSIONS: Patients with ASD undergoing operative treatment at baseline had greater sagittal deformity and greater improvement in health-related quality of life postoperatively compared to patients treated nonoperatively. Additionally, patients in the nonoperative cohort overall had an increase in ODI and did not show improvement in utility gained. Patients in the nonoperative cohort who had low disability and sagittal deformity underwent successful maintenance and cost-effective treatment.PMID:37728175 | DOI:10.3171/2023.7.SPINE23195
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Peter G Passias Waleed Ahmad Pooja Dave Renaud Lafage Virginie Lafage Jamshaid Mir Eric O Klineberg Khaled M Kabeish Jeffrey L Gum Breton G Line Robert Hart Douglas Burton Justin S Smith Christopher P Ames Christopher I Shaffrey Frank Schwab Richard Hosti Source Type: research

The life and legacy of John Robert Cobb: the man behind the angle
J Neurosurg Spine. 2023 Sep 8:1-8. doi: 10.3171/2023.7.SPINE23146. Online ahead of print.ABSTRACTIn 1934, Dr. John Robert Cobb moved to New York to serve as the Gibney Orthopedic Fellow at the Hospital for the Ruptured and Crippled, now known as the Hospital for Special Surgery. In this role, Cobb was faced with a unique task that would shape not only his personal career but also the fields of scoliosis and spine care: to design the first scoliosis specialty clinic. He critically reviewed the treatment methods for scoliosis outlined by prior pioneers in spine surgery and kept his own meticulous records of diagnoses, treatm...
Source: Journal of Neurosurgery.Spine - September 19, 2023 Category: Neurosurgery Authors: Kathleen S Botterbush Justin K Zhang Pranav S Chimakurty Philippe Mercier Tobias A Mattei Source Type: research

Risk factors for radiographic progression of proximal junctional fracture in patients undergoing surgical treatment for adult spinal deformity
CONCLUSIONS: The risk factors for further progression of PJFx were overcorrection relative to the age-adjusted PI-LL target at index surgery, PJA > 21° at initial presentation, and fracture at the UIV level. Close monitoring is warranted for such patients in order to not miss timely revision surgery.PMID:37657113 | DOI:10.3171/2023.7.SPINE23103
Source: Journal of Neurosurgery.Spine - September 1, 2023 Category: Neurosurgery Authors: Se-Jun Park Chong-Suh Lee Jin-Sung Park Chung-Youb Jeon Chang-Hyun Ma Tae Soo Shin Source Type: research

Does the presence of cervical deformity in patients with baseline mild myelopathy increase operative urgency in adult cervical spinal surgery? A retrospective analysis
CONCLUSIONS: The findings of this study demonstrate that a delay in surgery after the initial visit significantly increases the risk for major complications and reoperation in patients with CD with associated mild baseline myelopathy. Early operative treatment in this patient population may lower the risk of postoperative complications.PMID:37657110 | DOI:10.3171/2023.6.FOCUS23304
Source: Neurosurgical Focus - September 1, 2023 Category: Neurosurgery Authors: Peter S Tretiakov Emmanuel Budis Pooja Dave Jamshaid Mir Matthew Galetta Nathan Lorentz M Burhan Janjua Pawel P Jankowski Peter G Passias Source Type: research

Pseudarthrosis after four-level anterior cervical discectomy and fusion without posterior fixation
CONCLUSIONS: More than half of patients undergoing 4-level ACDF without posterior fixation demonstrated pseudarthrosis of at least 1 level-most commonly the distal C6-7 level. One patient required revision for symptomatic pseudarthrosis. Patient-reported outcomes showed significant improvements at 1-year follow-up, but clinical follow-up was limited. This is the largest series to date to evaluate fusion outcomes in 4-level ACDF.PMID:37657109 | DOI:10.3171/2023.6.FOCUS23303
Source: Neurosurgical Focus - September 1, 2023 Category: Neurosurgery Authors: Michael D White S Harrison Farber Mark A Pacult Corey T Walker James J Zhou Juan S Uribe Steve Chang Udaya K Kakarla Jay D Turner Source Type: research

Surgical strategies for the treatment of deformity-associated cervical spondylotic stretch myelopathy: a case series with technically nuanced illustrative operative videos
CONCLUSIONS: Deformity-associated cervical spondylotic stretch myelopathy often leads to devastating neurological decline and can significantly decrease quality of life. Carefully selected cases of circumferentially rigid cervical kyphosis can be successfully corrected with anterior-only osteotomies followed by posterior fixation while avoiding back-front-back operations.PMID:37657104 | DOI:10.3171/2023.6.FOCUS23279
Source: Neurosurgical Focus - September 1, 2023 Category: Neurosurgery Authors: Wilson A M Fisher Olivia E Gilbert Cheerag Upadhyaya Michael Galgano Source Type: research

Risk factors for radiographic progression of proximal junctional fracture in patients undergoing surgical treatment for adult spinal deformity
CONCLUSIONS: The risk factors for further progression of PJFx were overcorrection relative to the age-adjusted PI-LL target at index surgery, PJA > 21° at initial presentation, and fracture at the UIV level. Close monitoring is warranted for such patients in order to not miss timely revision surgery.PMID:37657113 | DOI:10.3171/2023.7.SPINE23103
Source: Journal of Neurosurgery.Spine - September 1, 2023 Category: Neurosurgery Authors: Se-Jun Park Chong-Suh Lee Jin-Sung Park Chung-Youb Jeon Chang-Hyun Ma Tae Soo Shin Source Type: research

Does the presence of cervical deformity in patients with baseline mild myelopathy increase operative urgency in adult cervical spinal surgery? A retrospective analysis
CONCLUSIONS: The findings of this study demonstrate that a delay in surgery after the initial visit significantly increases the risk for major complications and reoperation in patients with CD with associated mild baseline myelopathy. Early operative treatment in this patient population may lower the risk of postoperative complications.PMID:37657110 | DOI:10.3171/2023.6.FOCUS23304
Source: Neurosurgical Focus - September 1, 2023 Category: Neurosurgery Authors: Peter S Tretiakov Emmanuel Budis Pooja Dave Jamshaid Mir Matthew Galetta Nathan Lorentz M Burhan Janjua Pawel P Jankowski Peter G Passias Source Type: research

Pseudarthrosis after four-level anterior cervical discectomy and fusion without posterior fixation
CONCLUSIONS: More than half of patients undergoing 4-level ACDF without posterior fixation demonstrated pseudarthrosis of at least 1 level-most commonly the distal C6-7 level. One patient required revision for symptomatic pseudarthrosis. Patient-reported outcomes showed significant improvements at 1-year follow-up, but clinical follow-up was limited. This is the largest series to date to evaluate fusion outcomes in 4-level ACDF.PMID:37657109 | DOI:10.3171/2023.6.FOCUS23303
Source: Neurosurgical Focus - September 1, 2023 Category: Neurosurgery Authors: Michael D White S Harrison Farber Mark A Pacult Corey T Walker James J Zhou Juan S Uribe Steve Chang Udaya K Kakarla Jay D Turner Source Type: research

Surgical strategies for the treatment of deformity-associated cervical spondylotic stretch myelopathy: a case series with technically nuanced illustrative operative videos
CONCLUSIONS: Deformity-associated cervical spondylotic stretch myelopathy often leads to devastating neurological decline and can significantly decrease quality of life. Carefully selected cases of circumferentially rigid cervical kyphosis can be successfully corrected with anterior-only osteotomies followed by posterior fixation while avoiding back-front-back operations.PMID:37657104 | DOI:10.3171/2023.6.FOCUS23279
Source: Neurosurgical Focus - September 1, 2023 Category: Neurosurgery Authors: Wilson A M Fisher Olivia E Gilbert Cheerag Upadhyaya Michael Galgano Source Type: research

Risk factors for radiographic progression of proximal junctional fracture in patients undergoing surgical treatment for adult spinal deformity
CONCLUSIONS: The risk factors for further progression of PJFx were overcorrection relative to the age-adjusted PI-LL target at index surgery, PJA > 21° at initial presentation, and fracture at the UIV level. Close monitoring is warranted for such patients in order to not miss timely revision surgery.PMID:37657113 | DOI:10.3171/2023.7.SPINE23103
Source: Journal of Neurosurgery.Spine - September 1, 2023 Category: Neurosurgery Authors: Se-Jun Park Chong-Suh Lee Jin-Sung Park Chung-Youb Jeon Chang-Hyun Ma Tae Soo Shin Source Type: research