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Manifestation of acute appendicitis as known but paradox visceral side effect of ulcerative colitis anti-inflammatory therapy with januskinase-inhibitor Tofacitinib (Xeljanz ™)
CONCLUSION: Based on the paradoxon of an acute inflammatory disease (acute appendicitis) seen in the case of a patient undergoing immunosuppressive/anti-inflammatory treatment using a JAK-Inhibitor for ulcerative colitis, we consider this case worthy of publication although this side effect has previously been described in patients with rheumatoid arthritis. This might be the manifestation of i) an immunomodulatory effect that reduced or at least altered mucosal defense, including an increased risk of opportunistic infections, presenting as a specific visceral 'side effect' of the JAK-Inhibitor and/or as a consequence; ii)...
Source: Pathology, Research and Practice - July 2, 2023 Category: Pathology Authors: F Weber K I Eger C March R S Croner F Meyer Source Type: research

Rectal mass revealing peritoneal inclusion cyst with peritoneal endometriosis incidentally discovered: About a case and review of the literature
We report the case of a 29-year-old woman presenting a rectal mass for which the analysis of echo-endoscopic samples was not contributory. The PET-scan revealed a rectal submucosal mass and deep adenopathy. An exploratory laparoscopy was performed, and allowed to remove cystic inflammatory areas and lymph nodes. The histopathological study confirmed the diagnosis of peritoneal inclusion cyst with endometriosis and reactive adenitis. Peritoneal inclusion cyst is a rare condition that develops at the expense of the serosa. The risk of recurrence is high with a possibility of malignant transformation. Excision and monitoring ...
Source: Annales de Pathologie - May 18, 2023 Category: Pathology Authors: Zana Ismael Coulibaly Nejla Gumus Pieter Demetter Source Type: research

An adrenal cortical adenoma with neuroendocrine-type granules mimicking pheochromocytoma
Ultrastruct Pathol. 2023 Apr 11:1-5. doi: 10.1080/01913123.2023.2201314. Online ahead of print.ABSTRACTClinical and biochemical presentation of adrenal tumors may rarely conflict with their histologic features. In the present report, we describe a rare case of adrenal neoplasm clinically and biochemically labeled as pheochromocytoma which at histologic examination resulted adrenal cortical tumor. The neoplasm was examined with the electron microscope which revealed the presence of electron-dense neuroendocrine-type granules next to intracytoplasmic lipid droplets. The patient underwent laparoscopic left adrenalectomy which...
Source: Ultrastructural Pathology - April 11, 2023 Category: Pathology Authors: Leonardo Rossi Carlo Enrico Ambrosini Liborio Torregrossa Maria Margherita de Santi Raffaella Guazzo Tommaso Simoncini Alessandra Bacca Benard Gjeloshi Francesco Pignatelli Mattia Iachini Elisa Loguercio Chiara Becucci Gabriele Materazzi Source Type: research

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